20,402 research outputs found
How the Cervical Microbiota Contributes to Cervical Cancer Risk in Sub-Saharan Africa
Despite ongoing efforts, sub-Saharan Africa faces a higher cervical cancer burden than anywhere else in the world. Besides HPV infection, definitive factors of cervical cancer are still unclear. Particular states of the cervicovaginal microbiota and viral infections are associated with increased cervical cancer risk. Notably, HIV infection, which is prevalent in sub-Saharan Africa, greatly increases risk of cervicovaginal dysbiosis and cervical cancer. To better understand and address cervical cancer in sub-Saharan Africa, a better knowledge of the regional cervicovaginal microbiome is required This review establishes current knowledge of HPV, HIV, cervicovaginal infections, and the cervicovaginal microbiota in sub-Saharan Africa. Because population statistics are not available for the region, estimates are derived from smaller cohort studies. Microbiota associated with cervical inflammation have been found to be especially prevalent in sub-Saharan Africa, and to associate with increased cervical cancer risk. In addition to high prevalence and diversity of HIV and HPV, intracellular bacterial infections such as Chlamydia, Gonorrhea, and Mycoplasma hominis are much more common than in regions with a low burden of cervical cancer. This suggests the prevalence of cervical cancer in sub-Saharan Africa may be partially attributed to increased cervical inflammation resulting from higher likelihood of cervical infection and/or microbial dysbiosis
Ras/Raf-1/MAPK pathway mediates response to tamoxifen but not chemotherapy in breast cancer patients
<b>Purpose</b>: The expression and activation of the Ras/Raf-1/mitogen-activated protein kinase (MAPK) pathway plays an important role in the development and progression of cancer, and may influence response to treatments such as tamoxifen and chemotherapy. In this study we investigated whether the expression and activation of the key components of this pathway influenced clinical outcome, to test the hypothesis that activation of the MAPK pathway drives resistance to tamoxifen and chemotherapy in women with breast cancer.
<b>Experimental Design</b>: Breast tumors from patients at the Glasgow Royal Infirmary and others treated within the BR9601 trial were analyzed for expression of the three Ras isoforms, total Raf-1, active and inactive forms of Raf-1 [pRaf(ser338) and pRaf(ser259), respectively], MAPK, and phospho-MAPK using an immunohistochemical approach. Analyses were done with respect to disease free-survival and overall survival.
<b>Results</b>: Expression and activation of the Ras pathway was associated with loss of benefit from treatment with tamoxifen but not chemotherapy. Overexpression of pRaf(ser338) was associated with shortened disease-free and overall survival time in univariate analyses. Multivariate analysis suggested pRaf(ser338) was independent of known prognostic markers in predicting outcome following tamoxifen treatment (<i>P</i>=0.03).
<b>Conclusion</b>: This study suggests that activation of the Ras pathway predicts for poor outcome on tamoxifen but not chemotherapy, and identifies pRaf(ser338) as a potential marker of resistance to estrogen receptor–targeted therapy. In addition, it suggests that expression of pRaf(ser338) could identify patients for whom tamoxifen alone is insufficient adjuvant systemic therapy, but for whom the addition of chemotherapy may be of benefit
Prospects for Spectroscopic Reflected-light Planet Searches
High-resolution spectroscopic searches for the starlight reflected from
close-in extra-solar giant planets have the capability of determining the
optical albedo spectra and scattering properties of these objects. When
combined with radial velocity measurements they also yield the true mass of the
planet. To date, only two such planets have been targeted for reflected-light
signals, yielding upper limits on the planets' optical albedos. Here we examine
the prospects for future searches of this kind. We present Monte Carlo
estimates of prior probability distributions for the orbital velocity
amplitudes and planet/star flux ratios of 6 bright stars known to harbour giant
planets in orbits with periods of less than 5 days. Using these estimates, we
assess the viability of these targets for future reflected-light searches using
4m and 8m-class telescopes.Comment: 7 pages, 14 figures, MNRAS accepted 22 August 200
The Finite Field Kakeya Problem
A Besicovitch set in AG(n,q) is a set of points containing a line in every
direction. The Kakeya problem is to determine the minimal size of such a set.
We solve the Kakeya problem in the plane, and substantially improve the known
bounds for n greater than 4.Comment: 13 page
High magnetic field studies of the Vortex Lattice structure in YBa2Cu3O7
We report on small angle neutron scattering measurements of the vortex
lattice in twin-free YBa2Cu3O7, extending the previously investigated maximum
field of 11~T up to 16.7~T with the field applied parallel to the c axis. This
is the first microscopic study of vortex matter in this region of the
superconducting phase. We find the high field VL displays a rhombic structure,
with a field-dependent coordination that passes through a square configuration,
and which does not lock-in to a field-independent structure. The VL pinning
reduces with increasing temperature, but is seen to affect the VL correlation
length even above the irreversibility temperature of the lattice structure. At
high field and temperature we observe a melting transition, which appears to be
first order, with no detectable signal from a vortex liquid above the
transition
Stoichiometry control of sputtered CuCl thin films: Influence on ultraviolet emission properties
We demonstrate that the chemical composition of the sputtered CuCl thin films could be finely controlled by adjusting the bias to the substrate. The films deposited without any intentional bias were Cl rich (CuCl1+x), a bias of −22 V yielded stoichiometric CuCl, and a further increase in the negative bias resulted in Cl deficient films (CuCl1−x). The crystalline and optical properties were found to be associated with the chemical composition. Cl rich films showed a deep level green emission at around 515 nm in addition to ultraviolet (UV) excitonic emission. The stoichiometric films have higher optical quality, exhibiting a sharp UV emission at around 385 nm at room temperature, compared to nonstoichiometric samples. Visible luminescence related to deep level defects was not observed in the stoichiometric films. Changes in energy of the flux from the target and the subsequent ion bombardment on the substrate surface are correlated with the variations in chemical composition and their impact on the film microstructure and UV emission
- …