The spatial variation of Asian dust and marine aerosol contributions to glaciochemical signals in central Asia

Short-term (6 months to 17 years) glaciochemical records have been collected from several glacier basins in the mountains of central Asia. The spatial distribution of snow chemistry in central Asia is controlled by the influx of dust from the large expanse of arid and semiarid regions in central Asia. Glaciers in the Northern and Western Tibetan Plateau show elevated concentrations and elevated annual fluxes of calcium, sodium, chloride, sulphate and nitrate due to the influx of desert dust from nearby arid and semi-arid regions. Glaciers in the Southeastern Tibetan Plateau show lower concentrations and lower annual fluxes of major ions due to longer transport distances of dust from the arid and semi-arid regions of Western China. Snow from the Karakoram and Western Himalaya show ion concentrations similar to those in Southeastern Tibetan Plateau, but much higher annual fluxes suggesting that much of the aerosol and moisture transported with the westerly jet stream is removed as it ascends the Southwest margin of the Tibetan Plateau. Snow from the Southern slopes of the Eastern Himalayas shows very low concentrations and very low annual fluxes of major ions, indicating that this region is relatively free from the chemical influence of Asian dust. The glaciochemical data suggest that glaciers which are removed from large source areas of mineral aerosol, such as those in the Himalaya, the Karakoram, and the Southeastern Tibetan Plateau, are the ones most likely to contain longer-term glaciochemical records which detail annual to decadal variation in the strength of the Asian monsoon and long-range transport of Asian dust

A review of Central Asian glaciochemical data

The glaciers of central Asia provide suitable locations from which to recover continuous, high-resolution glaciochemical records on a continental scale. Although the glaciochemical investigations undertaken to date in central Asia are few in number and limited in terms of spatial coverage and length of record, some preliminary observations can be made concerning regional and seasonal trends in snow chemistry in this region. The sodium chloride ratio for most snow samples collected in central Asia approaches the ratio found in sea water (0.86 in /Leq kg-I ), reflecting a marine source for these constituents. Sodium and chloride concentrations are, on average, 3-10 times higher in the Himalayas than in the Karakoram, demonstrating the greater influence of monsoonal sources of moisture in the Himalayas. Very high sodium concentrations from Khel Khod Glacier probably reflect a local crustal source from surrounding ice-free areas. Low nitrate concentrations were found in snow collected from the southern margin of the Himalayas and high concentrations in snow deposited on the north margin of the Himalayas. This strong regional trend in the spatial distribution of nitrate suggests the influx of continental aerosols, rich in nitrate, originating from the arid regions of central Asia. High calcium concentrations measured in snow from Mount Everest and the north-west corner of China are also indicative of dust derived from the arid regions of central Asia. Very high sulfate concentrations found in snow from the Tien Shan and the Bogda Shan most likely reflect local anthropogenic sources. The altitude effect on isotopic composition is not apparent from snow samples collected in central Asia. Understanding the processes which control the chemical content of snow, the local-to-regional scale complexities, and the seasonal variability are fundamental steps necessary to assess the potential for recovering representative long-term glaciochemical records from central Asia

A comparison of medetomidine and its active enantiomer dexmedetomidine when administered with ketamine in mice

Medetomidine-ketamine (MK) and dexmedetomidine-ketamine (DK) are widely used to provide general anaesthesia in laboratory animals, but have not been compared directly in many of these species, including rodents. This study aimed to compare the onset and depth of anaesthesia, and changes in vital signs, after intraperitoneal (IP) or subcutaneous (SC) administration of ketamine (75 mg kg-1) combined with medetomidine (1 mg kg-1) or dexmedetomidine (0.5 mg kg-1) using a randomised semi-crossover design with >= 48 hours between treatments in 10 male and 10 female mice. Each mouse was anaesthetised twice using the same administration route (IP or SC): once with each drug-ketamine combination. Anaesthetised mice were monitored on a heating pad without supplemental oxygen for 89 minutes; atipamezole was administered for reversal. The times that the righting reflex was lost post-injection and returned post-reversal were analysed using general linear models. Tail-pinch and pedal reflexes were examined using binomial generalized linear models. Pulse rate (PR), respiratory rate (fr), and arterial haemoglobin saturation (SpO2) were compared using generalized additive mixed models. There were no significant differences among treatments for the times taken for loss and return of the righting reflex, or response of the tail-pinch reflex. The pedal withdrawal reflex was abolished more frequently with MK than DK over time (P = 0.021). The response of PR and SpO2 were similar among treatments, but fr was significantly higher with MK than DK (P <= 0.0005). Markedly low SpO2 concentrations occurred within 5 minutes post-injection (83.8 +/- 6.7 %) in all treatment groups and were most severe after 89 minutes lapsed (66.7 +/- 7.5 %). No statistical differences were detected in regards to administration route (P <= 0.94). This study failed to demonstrate clinical advantages of the enantiomer dexmedetomidine over medetomidine when combined with ketamine to produce general anaesthesia in mice. At the doses administered, deep surgical anaesthesia was not consistently produced with either combination; therefore, anaesthetic depth must be assessed before performing surgical procedures. Supplemental oxygen should always be provided during anaesthesia to prevent hypoxaemia

Anthropogenic Sulfate and Asian Dust Signals in Snow from Tien Shan, Northwest China

Snow samples were collected from a 0.5 m snowpack at Glacier No. I and near Bogda Feng, eastern Tien Shan, northwest China. Samples that were melted in the field were analyzed for chloride, nitrate, sulfate, sodium, potassium, magnesium, calcium, and microparticles. Eight samples were returned frozen and were analyzed for the above ions plus ammonium, acetate, formate, methylsulfonate, and hydrogen peroxide. There was no significant difference in measured major ion concentrations between the melted and frozen samples. Measured cations in both sets of samples were two to three times greater than measured anions. Calcium and sodium are the dominant cations while sulfate is the dominant measured anion. High ion burdens are associated with dusty layers in the snowpack, indicating that dust from the vast arid regions of central Asia is the dominant source for major ions in Tien Shan snow. The significant increase in sulfate and decrease in the cation: anion ratio in Bogda Feng snow relative to Glacier No. I snow suggest that anthropogenic emissions from Urtimqi are an important source of sulfate to precipitation downwind from the city

Scanning nano-spin ensemble microscope for nanoscale magnetic and thermal imaging

Quantum sensors based on solid-state spins provide tremendous opportunities in a wide range of fields from basic physics and chemistry to biomedical imaging. However, integrating them into a scanning probe microscope to enable practical, nanoscale quantum imaging is a highly challenging task. Recently, the use of single spins in diamond in conjunction with atomic force microscopy techniques has allowed significant progress towards this goal, but generalisation of this approach has so far been impeded by long acquisition times or by the absence of simultaneous topographic information. Here we report on a scanning quantum probe microscope which solves both issues, by employing a nano-spin ensemble hosted in a nanodiamond. This approach provides up to an order of magnitude gain in acquisition time, whilst preserving sub-100 nm spatial resolution both for the quantum sensor and topographic images. We demonstrate two applications of this microscope. We first image nanoscale clusters of maghemite particles through both spin resonance spectroscopy and spin relaxometry, under ambient conditions. Our images reveal fast magnetic field fluctuations in addition to a static component, indicating the presence of both superparamagnetic and ferromagnetic particles. We next demonstrate a new imaging modality where the nano-spin ensemble is used as a thermometer. We use this technique to map the photo-induced heating generated by laser irradiation of a single gold nanoparticle in a fluid environment. This work paves the way towards new applications of quantum probe microscopy such as thermal/magnetic imaging of operating microelectronic devices and magnetic detection of ion channels in cell membranes.Comment: 22 pages including Supporting Information. Changes to v1: affiliations and funding information updated, plus minor revisions to the main tex

Radicalisation of Young Adults in the Balkan States: Counter-Measures, Healthcare Provision, and Community Involvement

Decreasing the rise of extremism remains a priority for governments worldwide.  Motives behind joining an extremist organisation are complex and often unique to the individual, making prevention strategies difficult to design and implement.  This article explores several facets of this complex problem, particularly in relation to young adults, including links between extremism, criminality and incarceration, mental health, socioeconomic status and the rise of radicalisation ‘hotspots’ in Muslim majority states in the Western Balkans, where lack of government leadership allows extremist organisations to flourish.  Potential counter radicalisation measures are also discussed in various contexts, including healthcare systems, the community, internationally and within the Balkan region

MRL6: Hunter Corbett and Harold F. Smith Papers, 1862-1948

Corbett: pioneer Presbyterian missionary in Chefoo, China; Smith: son-in-law of Corbett, teacher in Chefoo School and Cheeloo University. Corbett’s diaries during itineration in Shantung; HC and HFS papers and correspondence covering major historical events in China, papers on education and higher education in China, 1900-1948; photographs and miscellaneous