A method for space-variant deblurring with application to adaptive optics imaging in astronomy

Images from adaptive optics systems are generally affected by significant distortions of the point spread function (PSF) across the field of view, depending on the position of natural and artificial guide stars. Image reduction techniques circumventing or mitigating these effects are important tools to take full advantage of the scientific information encoded in AO images. The aim of this paper is to propose a method for the deblurring of the astronomical image, given a set of samples of the space-variant PSF. The method is based on a partitioning of the image domain into regions of isoplanatism and on applying suitable deconvolution methods with boundary effects correction to each region. The effectiveness of the boundary effects correction is proved. Moreover, the criterion for extending the disjoint sections to partially overlapping sections is validated. The method is applied to simulated images of a stellar system characterized by a spatially variable PSF. We obtain good photometric quality, and therefore good science quality, by performing aperture photometry on the deblurred images. The proposed method is implemented in IDL in the Software Package "Patch", which is available on http://www.airyproject.eu.Comment: 11 pages, 9 figures, 7 tables, accepted by A&

Solar System Tests in Brans-Dicke and Palatini f(R)-theories

We compare Mercury's precession test in standard General Relativity (GR), Brans-Dicke theories (BD), and Palatini f(R)-theories. We avoid post Newtonian (PN) approximation and compute exact precession in these theories. We show that the well-known mathematical equivalence between Palatini f(R)-theories and a specific subset of BD theories does not extend to a really physical equivalence among theories since equivalent models still allow different incompatible precession for Mercury depending on the solution one chooses. As a result one cannot use BD equivalence to rule out Palatini f(R)-theories. On the contrary, we directly discuss that Palatini f(R)-theories can (and specific models do) easily pass Solar System tests as Mercury's precession.Comment: 22 pages, 2 figure

Constraints on the symmetry energy and on neutron skins from the pygmy resonances in 68Ni and 132Sn

Correlations between the behavior of the nuclear symmetry energy, the neutron skins, and the percentage of energy-weighted sum rule (EWSR) exhausted by the Pygmy Dipole Resonance (PDR) in 68Ni and 132Sn have been investigated by using different Random Phase Approximation (RPA) models for the dipole response, based on a representative set of Skyrme effective forces plus meson-exchange effective Lagrangians. A comparison with the experimental data has allowed us to constrain the value of the derivative of the symmetry energy at saturation. The neutron skin radius is deduced under this constraint.Comment: Accepted for publication in PRC Rapid Comminicatio

Deblurring of post-adaptive optics images

The novel and freely available ‘Patch’ software package can be used to deconvolve images that have spatially variable point spread functions

A Wearable System for Real-Time Continuous Monitoring of Physical Activity

Over the last decades, wearable systems have gained interest for monitoring of physiological variables, promoting health, and improving exercise adherence in different populations ranging from elite athletes to patients. In this paper, we present a wearable system for the continuous real-time monitoring of respiratory frequency (fR), heart rate (HR), and movement cadence during physical activity. The system has been experimentally tested in the laboratory (by simulating the breathing pattern with a mechanical ventilator) and by collecting data from one healthy volunteer. Results show the feasibility of the proposed device for real-time continuous monitoring of fR, HR, and movement cadence both in resting condition and during activity. Finally, different synchronization techniques have been investigated to enable simultaneous data collection from different wearable modules.Ministerio de Economía y Competitivida

3d printing for medicinal chemistry in space crafting our way to mars

Three Dimensional Printing (3DP) - defined by ISO as "fabrication of objects through the deposition of a material using a print head, nozzle, or another printer technology" - is an emerging component of Medicinal Chemistry (MC). Space provides a challenging environment where 3DP and MC can offer great services while expanding their borders, with regard to pharmaceutical design and tissue engineering. The purpose of this presentation is twofold. We first present an overview of existing and emerging applications of the 3DP - MC intersection in Space and we then discuss some debatable aspects from a legal point of view. This is a literature study. We searched biomedical (Pubmed, Google Scholar) and tech – oriented (InTech) databases with key words (3D Printing, Medicinal Chemistry, Space). Moreover we searched the official websites and depositories of national or international Space Agencies. 3DP equipment has recently been installed in the International Space Station marking a revolution in Space Research. 3DP in Space has been a synonym to Additive Manufacturing (AM). Astronauts will soon be able to print medication, instead of receiving it from Earth, or even grow tissues such as skin grafts in case of injuries. Clinical trials or pharmaceutical design experiments may be also carried out in microgravity environment. Last but not least, 3DP mediated MC research in Space investigate the recycling of previously used materials or even debris in pharmaceutical design and bioengineering. In the future 3DP is expected to play a crucial role in Space Exploration. Long term missions or even colonization of the Moon or Mars will not be possible unless the astronauts are able to produce medication, experimental kits and biomaterials among others on their own. The repercussions of such a 3DP - MC coalition are also expected to have an impact on Earth. Remote healthcare facilities, single laboratories and pharmacists and potentially any trained individual will be able to produce medication and biomaterials. Such a potential hides a considerable amount of controversy. Liability and safety issues, patent obtaining procedures and transferability of Space 3DP - MC research findings to Earth consist of emerging concepts in the field of Space Jurisdiction

New Approach to Optical Polarisation Mode Dispersion Mitigation: Experimental Analysis of the Dynamic Performances of a Cost-Driven Device

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Quantitation of regional ejection fractions using gated tomographic imaging with Tc-99m-sestamibi

BACKGROUND: A new oro-dispersible film (ODF) formulation of sildenafil has been developed for the treatment of erectile dysfunction (ED) to overcome the drawbacks that some patients experience when taking the conventional film-coated tablet (FCT). AIM: To assess the effectiveness and safety of sildenafil ODF formulation in patients with ED who were using the conventional FCT. METHODS: From May 2017 through July 2017, 139 patients with ED were enrolled. Data from penile color-duplex ultrasound, medical history, hormonal evaluation, and patient self-administered questionnaires were collected. All patients were administered sildenafil 100-mg FCT for 4 weeks. Thereafter, they underwent a 2-week washout period and subsequently took sildenafil 75-mg ODF for 4 weeks. OUTCOMES: The International Index of Erectile Function (IIEF-15), Hospital Anxiety and Depression Scale (HADS), Patient Global Impressions of Improvement (PGI-I), and Clinician Global Impressions of Improvement (CGI-I) questionnaires were administered and severity of ED was classified as severe (IIEF-15 score ≤ 10), moderate (IIEF-15 score 11-16), or mild (IIEF-15 score = 17-25). RESULTS: All patients completed the final protocol. Differences in mean IIEF scores for erectile function, orgasmic function, sexual desire, and intercourse satisfaction were significantly in favor of sildenafil 100-mg FCT, whereas the mean score for overall satisfaction was in favor of sildenafil 75-mg ODF. A significant difference in changes in HADS score was found from washout to final follow-up (mean difference = -0.19; P < .01). For the ODF formulation, the median CGI-I score was 3.5 (interquartile range [IQR] = 2.5-4.5) and the median PGI-I score was 3.0 (IQR = 2.0-4.0). The median action time was 20.0 minutes (IQR = 15.0-30.0) and the median mouth time was 60.0 seconds (IQR = 30.0-120.0). CLINICAL IMPLICATIONS: The ODF formulation of a widely known drug, with the same safety and effectiveness of the FCT, was better appreciated by patients in overall satisfaction. STRENGTHS AND LIMITATIONS: This is the first clinical trial to assess the efficacy of a new formulation of sildenafil in patients with ED. The limitations of the study are related to the methodology used: it was not a case-control study and the patients were not drug-naïve for ED treatment. Therefore, only the "additional" side effects of the ODF formulation compared with FCT are reported. CONCLUSION: The new ODF formulation is as efficient and safe as the FCT formulation and offers a new choice of treatment to specialists for more precisely tailored therapy. Cocci A, Capece M, Cito G, et al. Effectiveness and Safety of Oro-Dispersible Sildenafil in a New Film Formulation for the Treatment of Erectile Dysfunction: Comparison Between Sildenafil 100-mg Film-Coated Tablet and 75-mg Oro-Dispersible Film. J Sex Med 2017;X:XXX-XXX