567 research outputs found
Finite Temperature Wave-Function Renormalization, A Comparative Analysis
We compare two competing theories regarding finite temperature wave-function
corrections for the process and for and
related processes of interest for primordial nucleosynthesis. Although the two
methods are distinct (as shown in ) they yield the same finite
temperature correction for all and processes. Both methods
yield an increase in the He/H ratio of .01% due to finite temperature
renormalization rather than a decrease of .16% as previously predicted.Comment: 12 pages, 3 figures. LaTe
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Phenolic Glycolipid Facilitates Mycobacterial Escape from Microbicidal Tissue-Resident Macrophages
Mycobacterium tuberculosis (Mtb) enters the host in aerosol droplets deposited in lung alveoli, where the bacteria first encounter lung-resident alveolar macrophages. We studied the earliest mycobacterium-macrophage interactions in the optically transparent zebrafish. First-responding resident macrophages phagocytosed and eradicated infecting mycobacteria, suggesting that to establish a successful infection, mycobacteria must escape out of the initially infected resident macrophage into growth-permissive monocytes. We defined a critical role for mycobacterial membrane phenolic glycolipid (PGL) in engineering this transition. PGL activated the STING cytosolic sensing pathway in resident macrophages, inducing the production of the chemokine CCL2, which in turn recruited circulating CCR2+ monocytes towards infection. Transient fusion of infected macrophages with CCR2+ monocytes enabled bacterial transfer and subsequent dissemination, and interrupting this transfer so as to prolong mycobacterial sojourn in resident macrophages promoted clearing of infection. Human alveolar macrophages produced CCL2 upon Mtb infection, arguing for the potential of PGL-blocking interventions or PGL-targeting vaccine strategies in the prevention of tuberculosis.This work was supported by the NIH Director’s Pioneer Award, NIH grant R37AI054503, and a Wellcome Trust Principal Research Fellowship (L.R.), NIH training grant T32 AI55396 and a Damon Runyon Postdoctoral Fellowship (C.J.C.), the Health Research Board of Ireland (S.M.O., M.P.O., and J.K.), and The Royal City of Dublin Hospital Trust (J.K.)
Percolation properties of the 2D Heisenberg model
We analyze the percolation properties of certain clusters defined on
configurations of the 2--dimensional Heisenberg model. We find that, given any
direction \vec{n} in O(3) space, the spins almost perpendicular to \vec{n} form
a percolating cluster. This result gives indications of how the model can avoid
a previously conjectured Kosterlitz-Thouless phase transition at finite
temperature T.Comment: 4 pages, 3 eps figures. Revised version (more clear abstract, some
new references
On some singularities of the correlation functions that determine neutrino opacities
Certain perturbation graphs in the calculation of the effects of the medium
on neutrino scattering in supernova matter have a nonintegrable singularity in
a physical region. A number of papers have addressed the apparent pathology
through an ansatz that invokes higher order (rescattering) effects. Taking the
Gamow-Teller terms as an example, we display an expression for the spin-spin
correlation function that determines the cross-sections. It is clear from the
form that there are no pathologies in the order by order perturbation
expansion. Explicit formulae are given for a simple case, leading to an answer
that is very different from one given by other authors.Comment: 8 page
γδ T cells affect IL-4 production and B-cell tolerance
γδ T cells can influence specific antibody responses. Here, we report that mice deficient in individual γδ T-cell subsets have altered levels of serum antibodies, including all major subclasses, sometimes regardless of the presence of αβ T cells. One strain with a partial γδ deficiency that increases IgE antibodies also displayed increases in IL-4–producing T cells (both residual γδ T cells and αβ T cells) and in systemic IL-4 levels. Its B cells expressed IL-4–regulated inhibitory receptors (CD5, CD22, and CD32) at diminished levels, whereas IL-4–inducible IL-4 receptor α and MHCII were increased. They also showed signs of activation and spontaneously formed germinal centers. These mice displayed IgE-dependent features found in hyper-IgE syndrome and developed antichromatin, antinuclear, and anticytoplasmic autoantibodies. In contrast, mice deficient in all γδ T cells had nearly unchanged Ig levels and did not develop autoantibodies. Removing IL-4 abrogated the increases in IgE, antichromatin antibodies, and autoantibodies in the partially γδ-deficient mice. Our data suggest that γδ T cells, controlled by their own cross-talk, affect IL-4 production, B-cell activation, and B-cell tolerance
Susceptibility and Percolation in 2D Random Field Ising Magnets
The ground state structure of the two-dimensional random field Ising magnet
is studied using exact numerical calculations. First we show that the
ferromagnetism, which exists for small system sizes, vanishes with a large
excitation at a random field strength dependent length scale. This {\it
break-up length scale} scales exponentially with the squared random
field, . By adding an external field we then study the
susceptibility in the ground state. If , domains melt continuously and
the magnetization has a smooth behavior, independent of system size, and the
susceptibility decays as . We define a random field strength dependent
critical external field value , for the up and down spins to
form a percolation type of spanning cluster. The percolation transition is in
the standard short-range correlated percolation universality class. The mass of
the spanning cluster increases with decreasing and the critical
external field approaches zero for vanishing random field strength, implying
the critical field scaling (for Gaussian disorder) , where and .
Below the systems should percolate even when H=0. This implies that
even for H=0 above the domains can be fractal at low random fields, such
that the largest domain spans the system at low random field strength values
and its mass has the fractal dimension of standard percolation .
The structure of the spanning clusters is studied by defining {\it red
clusters}, in analogy to the ``red sites'' of ordinary site-percolation. The
size of red clusters defines an extra length scale, independent of .Comment: 17 pages, 28 figures, accepted for publication in Phys. Rev.
Finite temperature effects on cosmological baryon diffusion and inhomogeneous Big-Bang nucleosynthesis
We have studied finite temperature corrections to the baryon transport cross
sections and diffusion coefficients. These corrections are based upon the
recently computed renormalized electron mass and the modified state density due
to the background thermal bath in the early universe. It is found that the
optimum nucleosynthesis yields computed using our diffusion coefficients shift
to longer distance scales by a factor of about 3. We also find that the minimum
value of abundance decreases by while and
increase. Effects of these results on constraints from primordial
nucleosynthesis are discussed. In particular, we find that a large baryonic
contribution to the closure density (\Omega_b h_{50}^{2} \lsim 0.4) may be
allowed in inhomogeneous models corrected for finite temperature.Comment: 7 pages, 6 figures, submitted to Phys. Rev.
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