308 research outputs found
Atomic oxygen adsorption and incipient oxidation of the Pb(111) surface: A density-functional theory study
We study the atomic oxygen adsorption on Pb(111) surface by using
density-functional theory within the generalized gradient approximation and a
supercell approach. The atomic and energetic properties of purely on-surface
and subsurface oxygen structures at the Pb(111) surface are systematically
investigated for a wide range of coverages and adsorption sites. The fcc and
tetra-II sites (see the text for definition) are found to be energetically
preferred for the on-surface and subsurface adsorption, respectively, in the
whole range of coverage considered. The on-surface and subsurface oxygen
binding energies monotonically increase with the coverage, and the latter is
always higher than the former, thus indicating the tendency to the formation of
oxygen islands (clusters) and the higher stability of subsurface adsorption.
The on-surface and subsurface diffusion-path energetics of atomic oxygen, and
the activation barriers for the O penetration from the on-surface to the
subsurface sites are presented at low and high coverages. In particular, it is
shown that the penetration barrier from the on-surface hcp to the subsurface
tetra-I site is as small as 65 meV at low coverage (=0.25). The other
properties of the O/Pb(111) system, including the charge distribution, the
lattice relaxation, the work function, and the electronic density of states,
are also studied and discussed in detail, which consistently show the gradually
stabilizing ionic O-Pb bond with increase of the oxygen coverage.Comment: 31 pages, 16 figure
Parallax of PSR J1744-1134 and the Local Interstellar Medium
We present the annual trigonometric parallax of PSR J1744-1134 derived from
an analysis of pulse times of arrival. The measured parallax, pi = 2.8+/-0.3
mas ranks among the most precisely determined distances to any pulsar. The
parallax distance of 357+/-39 pc is over twice that derived from the dispersion
measure using the Taylor & Cordes model for the Galactic electron distribution.
The mean electron density in the path to the pulsar, n_e = (0.0088 +/- 0.0009)
cm^{-3}, is the lowest for any disk pulsar. We have compared the n_e for PSR
J1744-1134 with those for another 11 nearby pulsars with independent distance
estimates. We conclude that there is a striking asymmetry in the distribution
of electrons in the local interstellar medium. The electron column densities
for pulsars in the third Galactic quadrant are found to be systematically
higher than for those in the first. The former correlate with the position of
the well known local HI cavity in quadrant three. The excess electrons within
the cavity may be in the form of HII clouds marking a region of interaction
between the local hot bubble and a nearby superbubble.Comment: revised version accepted for publication in ApJ Letters; reanalysis
of uncertainty in parallax measure and changes to fig
Casimir Scaling from Center Vortices: Towards an Understanding of the Adjoint String Tension
We argue that the approximate ``Casimir scaling'' of the string tensions of
higher-representation Wilson loops is an effect due to the finite thickness of
center vortex configurations. It is shown, in the context of a simple model of
the Z(2) vortex core, how vortex condensation in Yang-Mills theory can account
for both Casimir scaling in intermediate size loops, and color-screening in
larger loops. An implication of our model is that the deviations from exact
Casimir scaling, which tend to grow with loop size, become much more pronounced
as the dimensionality of the group representation increases.Comment: 13 pages, including 3 eps figures, Latex2e. Two references adde
Diffusion as mixing mechanism in granular materials
We present several numerical results on granular mixtures. In particular, we
examine the efficiency of diffusion as a mixing mechanism in these systems. The
collisions are inelastic and to compensate the energy loss, we thermalize the
grains by adding a random force. Starting with a segregated system, we show
that uniform agitation (heating) leads to a uniform mixture of grains of
different sizes. We define a characteristic mixing time, , and
study theoretically and numerically its dependence on other parameters like the
density. We examine a model for bidisperse systems for which we can calculate
some physical quantities. We also examine the effect of a temperature gradient
and demonstrate the appearance of an expected segregation.Comment: 15 eps figures, include
New procedures for testing whether stock price processes are martingales
We propose procedures for testing whether stock price processes are
martingales based on limit order type betting strategies. We first show that
the null hypothesis of martingale property of a stock price process can be
tested based on the capital process of a betting strategy. In particular with
high frequency Markov type strategies we find that martingale null hypotheses
are rejected for many stock price processes
Old Wolrd Canis spp. with taxonomic ambiguity: Workshop conclusions and recommendations Vairao, Portugal, 28th-30th May 2019
Non peer reviewe
Maternal anthropometric characteristics in pregnancy and blood pressure among adolescents: 1993 live birth cohort, Pelotas, southern Brazil
<p>Abstract</p> <p>Background</p> <p>We investigated the association between maternal anthropometric measurements in prepregnancy and at the end of pregnancy and their children's systolic (SBP) and diastolic (DBP) blood pressure at 11 years of age, in a prospective cohort study.</p> <p>Methods</p> <p>All hospital births which took place in 1993 in the city of Pelotas - Brazil, were identified (5,249 live births). In 2004, the overall proportion of follow-up was 85% and we obtained arterial blood pressure measurements of 4,452 adolescents.</p> <p>Results</p> <p>Independent variables analyzed included maternal prepregnancy weight and body mass index (BMI) and maternal weight, and height at the end of pregnancy. Multiple linear regression analysis controlling for the following confounders were carried out: adolescent's skin color, family income at birth, smoking, alcohol intake during pregnancy, and gestational arterial hypertension. Mean SBP and DBP were 101.9 mmHg (SD 12.3) and 63.4 mmHg (SD 9.9), respectively. Maternal prepregnancy weight and BMI, and weight at the end of pregnancy were positively associated with both SBP and DBP in adolescent subjects of both sexes; maternal height was positively associated with SBP only among males.</p> <p>Conclusions</p> <p>Adequate evaluation of maternal anthropometric characteristics during pregnancy may prevent high levels of blood pressure among adolescent children.</p
Planeamiento territorial sostenible: un reto para el futuro de nuestras sociedades; criterios aplicados
In a large part of the 17 sustainable development objectives set as goals for humanity by the UN, sustainability can be glimpsed. As a result of the dominant socio-productive model, the only way to head towards more sustainable territories that allow achieving and maintaining the well-being of the world's population is to bear in mind the need to properly plan territorial development. This work reflects on this need and takes a step forward in the definition of the main criteria to achieve territorial sustainability at regional and local scales
Downregulation of SAV1 plays a role in pathogenesis of high-grade clear cell renal cell carcinoma
<p>Abstract</p> <p>Background</p> <p>Clinical outcome of patients with high-grade ccRCC (clear cell renal cell carcinoma) remains still poor despite recent advances in treatment strategies. Molecular mechanism of pathogenesis in developing high-grade ccRCC must be clarified. In the present study, we found that SAV1 was significantly downregulated with copy number loss in high-grade ccRCCs. Therefore, we investigated the SAV1 function on cell proliferation and apoptosis in vitro. Furthermore, we attempted to clarify the downstream signaling which is regulated by SAV1.</p> <p>Methods</p> <p>We performed array CGH and gene expression analysis of 8 RCC cell lines (786-O, 769-P, KMRC-1, KMRC-2, KMRC-3, KMRC-20, TUHR4TKB, and Caki-2), and expression level of mRNA was confirmed by quantitative RT-PCR (qRT-PCR) analysis. We next re-expressed SAV1 in 786-O cells, and analyzed its colony-forming activity. Then, we transfected siRNAs of SAV1 into the kidney epithelial cell line HK2 and renal proximal tubule epithelial cells (RPTECs), and analyzed their proliferation and apoptosis. Furthermore, the activity of YAP1, which is a downstream molecule of SAV1, was evaluated by western blot analysis, reporter assay and immunohistochemical analysis.</p> <p>Results</p> <p>We found that SAV1, a component of the Hippo pathway, is frequently downregulated in high-grade ccRCC. SAV1 is located on chromosome 14q22.1, where copy number loss had been observed in 7 of 12 high-grade ccRCCs in our previous study, suggesting that gene copy number loss is responsible for the downregulation of SAV1. Colony-forming activity by 786-O cells, which show homozygous loss of SAV1, was significantly reduced when SAV1 was re-introduced exogenously. Knockdown of SAV1 promoted proliferation of HK2 and RPTEC. Although the phosphorylation level of YAP1 was low in 786-O cells, it was elevated in SAV1-transduced 786-O cells. Furthermore, the transcriptional activity of the YAP1 and TEAD3 complex was inhibited in SAV1-transduced 786-O cells. Immunohistochemistry frequently demonstrated nuclear localization of YAP1 in ccRCC cases with SAV1 downregulation, and it was preferentially detected in high-grade ccRCC.</p> <p>Conclusions</p> <p>Taken together, downregulation of SAV1 and the consequent YAP1 activation are involved in the pathogenesis of high-grade ccRCC. It is an attractive hypothesis that Hippo signaling could be candidates for new therapeutic target.</p
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