Mechanical Competence Of Ovariectomy-induced Compromised Bone After Single Or Combined Treatment With High-frequency Loading And Bisphosphonates

Osteoporosis leads to increased bone fragility, thus effective approaches enhancing bone strength are needed. Hence, this study investigated the effect of single or combined application of high-frequency (HF) loading through whole body vibration (WBV) and alendronate (ALN) on the mechanical competence of ovariectomy-induced osteoporotic bone. Thirty-four female Wistar rats were ovariectomized (OVX) or sham-operated (shOVX) and divided into five groups: shOVX, OVX-shWBV, OVX-WBV, ALN-shWBV and ALN-WBV. (Sham) WBV loading was applied for 10 min/day (130 to 150 Hz at 0.3g) for 14 days and ALN at 2 mg/kg/dose was administered 3x/week. Finite element analysis based on micro-CT was employed to assess bone biomechanical properties, relative to bone micro-structural parameters. HF loading application to OVX resulted in an enlarged cortex, but it was not able to improve the biomechanical properties. ALN prevented trabecular bone deterioration and increased bone stiffness and bone strength of OVX bone. Finally, the combination of ALN with HF resulted in an increased cortical thickness in OVX rats when compared to single treatments. Compared to HF loading, ALN treatment is preferred for improving the compromised mechanical competence of OVX bone. In addition, the association of ALN with HF loading results in an additive effect on the cortical thickness.5Fund for Scientific Research of Flanders (FWO Vlaanderen)Brazilian Science Without Borders Program [246131/2012-8

Perfil dos produtores rurais do Rio Pardo de Minas: estudo de caso nas comunidades Monte Alegre, Vereda Funda e Água Boa (I e II).

Resumo - O estudo objetiva traçar o perfil técnico-econômico, social, ambiental e institucional dos produtores rurais de três comunidades do município de Rio Pardo de Minas (Vereda Funda; Água Boa I e II e Monte Alegre), sendo um esforço inicial na busca por compreender as necessidades, demandas e aspirações da agricultura familiar local. O levantamento é resultado de dados primários coletados por meio de visitas exploratórias e da aplicação de 92 questionários semiestruturados. Um resultado interessante foi perceber que os produtores rurais, embora com baixos níveis de produtividade, escolaridade e de capacitação técnica, têm consciência da necessidade da preservação ambiental, dos seus fatores críticos e dos gargalos estruturais que determinam o fraco nível de desenvolvimento econômico local. O estudo permitiu concluir que algumas soluções tecnológicas simples e intervenções públicas plausíveis poderiam gerar benefícios imediatos para as comunidades, tais como: melhorar os sistemas de produção e práticas de manejo; aumentar a qualidade da mão de obra por meio de capacitação e assistência técnica; direcionar mais crédito rural para investimento em cisternas, poços artesianos, sistemas de irrigação, insumos agropecuários (como máquinas e equipamentos, adubos e fertilizantes, defensivos agrícolas), dentre outros. Abstract - The study aims to trace the technical, economic, social, environmental and institutional profile of farmers in three communities of Rio Pardo de Minas (Vereda Funda, Água Boa I and II and Monte Alegre), being an initial effort in the search for understanding the needs, demands and aspirations of the local family farmers. The survey is the result of primary data collected through exploratory visits and application of 92 semi-structured questionnaires. An interesting result was to realize that farmers, albeit with low levels of productivity, education and technical training, are very aware of the environmental preservation´s need and the critical structural factors that determine the low level of local economic development. The study concluded that some simple technological solutions and plausible public interventions could bring immediate benefits to the three communities farmers, such as improving production systems and management practices; increase the quality of labor force through training and technical assistance; direct more rural credit for investment in water tanks, wells, irrigation systems, agricultural inputs (such as machinery and equipment, fertilizers, pesticides), among others

Perfil dos produtores rurais de Rio Pardo de Minas: estudo de caso nas comunidades Monte Alegre, Vereda Funda e Água Boa (I e II).

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ARIA 2016: Care pathways implementing emerging technologies for predictive medicine in rhinitis and asthma across the life cycle

Abstract The Allergic Rhinitis and its Impact on Asthma (ARIA) initiative commenced during a World Health Organization workshop in 1999. The initial goals were (1) to propose a new allergic rhinitis classification, (2) to promote the concept of multi-morbidity in asthma and rhinitis and (3) to develop guidelines with all stakeholders that could be used globally for all countries and populations. ARIA—disseminated and implemented in over 70 countries globally—is now focusing on the implementation of emerging technologies for individualized and predictive medicine. MASK [MACVIA (Contre les Maladies Chroniques pour un Vieillissement Actif)-ARIA Sentinel NetworK] uses mobile technology to develop care pathways for the management of rhinitis and asthma by a multi-disciplinary group and by patients themselves. An app (Android and iOS) is available in 20 countries and 15 languages. It uses a visual analogue scale to assess symptom control and work productivity as well as a clinical decision support system. It is associated with an inter-operable tablet for physicians and other health care professionals. The scaling up strategy uses the recommendations of the European Innovation Partnership on Active and Healthy Ageing. The aim of the novel ARIA approach is to provide an active and healthy life to rhinitis sufferers, whatever their age, sex or socio-economic status, in order to reduce health and social inequalities incurred by the disease

Commentaries on Viewpoint: The ongoing need for good physiological investigation: Obstructive sleep apnea in HIV patients as a paradigm

The final publication is available via http://dx.doi.org/10.1152/japplphysiol.00989.2014[Abstract] The intriguing paradigm put forth by Darquenne et al. (3) highlighted that improved therapy against human immunodeficiency virus (HIV) has come at the cost of elevated rates of chronic diseases, such as obstructive sleep apnea (OSA) and obesity, during the highly active antiretroviral therapy (HAART) era.Ministerio de Economía y Competitividad; TIN2013-40686-P