From Collapse to Freezing in Random Heteropolymers

We consider a two-letter self-avoiding (square) lattice heteropolymer model of N_H (out ofN) attracting sites. At zero temperature, permanent links are formed leading to collapse structures for any fraction rho_H=N_H/N. The average chain size scales as R = N^{1/d}F(rho_H) (d is space dimension). As rho_H --> 0, F(rho_H) ~ rho_H^z with z={1/d-nu}=-1/4 for d=2. Moreover, for 0 < rho_H < 1, entropy approaches zero as N --> infty (being finite for a homopolymer). An abrupt decrease in entropy occurs at the phase boundary between the swollen (R ~ N^nu) and collapsed region. Scaling arguments predict different regimes depending on the ensemble of crosslinks. Some implications to the protein folding problem are discussed.Comment: 4 pages, Revtex, figs upon request. New interpretation and emphasis. Submitted to Europhys.Let

Flavor-oscillation clocks, continuous quantum measurements and a violation of Einstein equivalence principle

The relation between Einstein equivalence principle and a continuous quantum measurement is analyzed in the context of the recently proposed flavor-oscillation clocks, an idea pioneered by Ahluwalia and Burgard (Gen. Rel Grav. Errata 29, 681 (1997)). We will calculate the measurement outputs if a flavor-oscillation clock, which is immersed in a gravitational field, is subject to a continuous quantum measurement. Afterwards, resorting to the weak equivalence principle, we obtain the corresponding quantities in a freely falling reference frame. Finally, comparing this last result with the measurement outputs that would appear in a Minkowskian spacetime it will be found that they do not coincide, in other words, we have a violation of Einstein equivalence principle. This violation appears in two different forms, namely: (i) the oscillation frequency in a freely falling reference frame does not match with the case predicted by general relativity, a feature previously obtained by Ahluwalia; (ii) the probability distribution of the measurement outputs, obtained by an observer in a freely falling reference frame, does not coincide with the results that would appear in the case of a Minkowskian spacetime.Comment: 16 pages, accepted in Mod. Phys. Letts.

Monte Carlo simulations of post-common-envelope white dwarf + main sequence binaries: The effects of including recombination energy

Detached WD+MS PCEBs are perhaps the most suitable objects for testing predictions of close-compact binary-star evolution theories, in particular, CE evolution. The population of WD+MS PCEBs has been simulated by several authors in the past and compared with observations. However, most of those predictions did not take the possible contributions to the envelope ejection from additional sources of energy (mostly recombination energy) into account. Here we update existing binary population models of WD+MS PCEBs by assuming that a fraction of the recombination energy available within the envelope contributes to ejecting the envelope. We performed Monte Carlo simulations of 10^7 MS+MS binaries for 9 different models using standard assumptions for the initial primary mass function, binary separations, and initial-mass-ratio distribution and evolved these systems using the publicly available BSE code. Including a fraction of recombination energy leads to a clear prediction of a large number of long orbital period (>~10 days) systems mostly containing high-mass WDs. The fraction of systems with He-core WD primaries increases with the CE efficiency and the existence of very low-mass He WDs is only predicted for high values of the CE efficiency (>~0.5). All models predict on average longer orbital periods for PCEBs containing C/O-core WDs than for PCEBs containing He WDs. This effect increases with increasing values of both efficiencies. Longer periods after the CE phase are also predicted for systems containing more massive secondary stars. The initial-mass-ratio distribution affects the distribution of orbital periods, especially the distribution of secondary star masses. Our simulations, in combination with a large and homogeneous observational sample, can provide constraints on the values of the CE efficiencies, as well as on the initial-mass-ratio distribution for MS+MS binary stars.Comment: 11 pages, 10 figures, accepted for publication in A&

Monte Carlo simulations of post-common-envelope white dwarf + main sequence binaries: comparison with the SDSS DR7 observed sample

Detached white dwarf + main sequence (WD+MS) systems represent the simplest population of post-common envelope binaries (PCEBs). Since the ensemble properties of this population carries important information about the characteristics of the common-envelope (CE) phase, it deserves close scrutiny. However, most population synthesis studies do not fully take into account the effects of the observational selection biases of the samples used to compare with the theoretical simulations. Here we present the results of a set of detailed Monte Carlo simulations of the population of WD+MS binaries in the Sloan Digital Sky Survey (SDSS) Data Release 7. We used up-to-date stellar evolutionary models, a complete treatment of the Roche lobe overflow episode, and a full implementation of the orbital evolution of the binary systems. Moreover, in our treatment we took into account the selection criteria and all the known observational biases. Our population synthesis study allowed us to make a meaningful comparison with the available observational data. In particular, we examined the CE efficiency, the possible contribution of internal energy, and the initial mass ratio distribution (IMRD) of the binary systems. We found that our simulations correctly reproduce the properties of the observed distribution of WD+MS PCEBs. In particular, we found that once the observational biases are carefully taken into account, the distribution of orbital periods and of masses of the WD and MS stars can be correctly reproduced for several choices of the free parameters and different IMRDs, although models in which a moderate fraction (<=10%) of the internal energy is used to eject the CE and in which a low value of CE efficiency is used (<=0.3) seem to fit better the observational data. We also found that systems with He-core WDs are over-represented in the observed sample, due to selection effects.Comment: 15 pages, 7 figures, accepted for publication in A&

Entropic Barriers, Frustration and Order: Basic Ingredients in Protein Folding

We solve a model that takes into account entropic barriers, frustration, and the organization of a protein-like molecule. For a chain of size $M$, there is an effective folding transition to an ordered structure. Without frustration, this state is reached in a time that scales as $M^{\lambda}$, with $\lambda\simeq 3$. This scaling is limited by the amount of frustration which leads to the dynamical selectivity of proteins: foldable proteins are limited to $\sim 300$ monomers; and they are stable in {\it one} range of temperatures, independent of size and structure. These predictions explain generic properties of {\it in vivo} proteins.Comment: 4 pages, 4 Figures appended as postscript fil

CD46-Mediated Transduction of a Species D Adenovirus Vaccine Improves Mucosal Vaccine Efficacy

The high levels of preexisting immunity against Adenovirus type 5 (Ad5) have deemed Ad5 unusable for translation as a human vaccine vector. Low seroprevalent alternative viral vectors may be less impacted by preexisting immunity, but they may also have significantly different phenotypes from that of Ad5. In this study we compare species D Ads (26, 28, and 48) to the species C Ad5. In vitro transduction studies show striking differences between the species C and D viruses. Most notably, Ad26 transduced human dendritic cells much more effectively than Ad5. In vivo imaging studies showed strikingly different transgene expression profiles. The Ad5 virus was superior to the species D viruses in BALB/c mice when delivered intramuscularly. However, the inverse was true when the viruses were delivered mucosally via the intranasal epithelia. Intramuscular transduction was restored in mice that ubiquitously expressed human CD46, the primary receptor for species D viruses. We analyzed both species C and D Ads for their ability to induce prophylactic immunity against influenza in the CD46 transgenic mouse model. Surprisingly, the species D vaccines again failed to induce greater levels of protective immunity as compared with the species C Ad5 when delivered intramuscularly. However, the species D Ad vaccine vector, Ad48, induced significantly greater protection as compared with Ad5 when delivered mucosally via the intranasal route in CD46 transgenic mice. These data shed light on the complexities between the species and types of Ad. Our findings indicate that more research will be required to identify the mechanisms that play a key role in the induction of protective immunity induced by species D Ad vaccines

Field theoretic approach to the counting problem of Hamiltonian cycles of graphs

A Hamiltonian cycle of a graph is a closed path that visits each site once and only once. I study a field theoretic representation for the number of Hamiltonian cycles for arbitrary graphs. By integrating out quadratic fluctuations around the saddle point, one obtains an estimate for the number which reflects characteristics of graphs well. The accuracy of the estimate is verified by applying it to 2d square lattices with various boundary conditions. This is the first example of extracting meaningful information from the quadratic approximation to the field theory representation.Comment: 5 pages, 3 figures, uses epsf.sty. Estimates for the site entropy and the gamma exponent indicated explicitl