biological properties of hsc scientific basis for hsct

Hematopoiesis—from the Greek term for "blood making"—is the adaptive process by which mature and functional blood cells are continuously replaced over the entire lifetime of an individual. Erythrocytes, platelets, and the various subsets of leukocytes all have finite although different life spans. As a consequence, the daily production of red blood cells, platelets, and neutrophils in homeostatic conditions amount to more than 300 billion cells

The value of multiple earthquake missions: the EEFIT L’Aquila Earthquake experience

In November 2012 EEFIT launched its first ever return mission to an earthquake affected site. The L’Aquila Earthquake site was chosen as this is a recent European event of interest to the UK and European earthquake engineering community. The main aims of this return mission were to document the earthquake recovery process and this paper presents an overview of the post-disaster emergency phase and transition to reconstruction in the Aquila area after the earthquake. It takes an earthquake engineering perspective, highlighting areas mainly of interest to the fields of structural/seismic engineering and reconstruction management. Within the paper, reference is made to published literature, but also to data collected in the field during the return mission that would not otherwise have been available. The paper presents some specific observations and lessons learned from the L’Aquila return mission. However, in light of current international efforts in conducting return missions, the paper ends with some reflections on the value that return missions can provide to the field of earthquake engineering in general, based on the EEFIT L’Aquila experience

Postprocedural management of patients after transcatheter aortic valve implantation procedure with self-expanding bioprosthesis

Background: Transcatheter aortic valve implantation (TAVI) carries higher risk of post-procedural adverse events than conventional percutaneous cardiovascular interventions. We report our experience about postoperative management protocol adopted in our Division. Methods: One hundred and ten patients underwent TAVI and 108 were transferred to the cardiac intensive care unit (CICU) after procedure. During the first 48 hours, vital parameters were monitored continuously. Close attention was given to rhythm and atrio-ventricular conduction disturbances, systemic blood pressure, fluid balance and vascular accesses. Results: The most common complications were renal impairment (21.3%), femoral artery pseudo-aneurysms (FAP) (11%), new complete atrioventricular block (20.3 %), cerebral vascular accident (4.5%) and cardiac perforation due to temporary pacemaker lead (1.8%). Ultrasound-guided compression repair was considered the first line treatment for FAP, but in 6 cases surgical treatment was immediately performed due to the rapid expansion of FAP. Complete atrio-ventricular block occurred in 22 patients (20.3 %) within the first 24 hours after TAVI and a permanent pacemaker was implanted in 21 patients (19.1%). Acute kidney injury occurred in 18 patients (35%) with pre-procedural chronic renal failure and in 5 patients (9%) without preoperative renal dysfunction. Conclusions: After TAVI, cardiovascular complications are common and therefore accurate standardized management of patients in CICU during the first 48 hours is mandatory to early detect and manage complications and to decrease the rate of adverse events and the length of in-hospital stay. (C) 2010 Wiley-Liss, Inc