Casimir energy and the superconducting phase transition

We study the influence of Casimir energy on the critical field of a superconducting film, and we show that by this means it might be possible to directly measure, for the first time, the variation of Casimir energy that accompanies the superconducting transition. It is shown that this novel approach may also help clarifying the long-standing controversy on the contribution of TE zero modes to the Casimir energy in real materials.Comment: 12 pages, 5 figures. Talk given at 7th Workshop on Quantum Field Theory Under the Influence of External Conditions (QFEXT 05), Barcelona, Catalonia, Spain, 5-9 Sep 200

Gravitational effects on a rigid Casimir cavity

Vacuum fluctuations produce a force acting on a rigid Casimir cavity in a weak gravitational field. Such a force is here evaluated and is found to have opposite direction with respect to the gravitational acceleration; the order of magnitude for a multi-layer cavity configuration is analyzed and experimental detection is discussed, bearing in mind the current technological resources.Comment: 7 pages, Latex. Talk given at the Fifth Leipzig Workshop on Quantum Field Theory under the Influence of External Conditions, September 200

Study of RPC gas mixtures for the ARGO-YBJ experiment

The ARGO-YBJ experiment consists of a RPC carpet to be operated at the Yangbajing laboratory (Tibet, P.R. China), 4300 m a.s.l., and devoted to the detection of showers initiated by photon primaries in the energy range 100 GeV - 20 TeV. The measurement technique, namely the timing on the shower front with a few tens of particles, requires RPC operation with 1 ns time resolution, low strip multiplicity, high efficiency and low single counting rate. We have tested RPCs with many gas mixtures, at sea level, in order to optimize these parameters. The results of this study are reported.Comment: 6 pages, 3 figures. To be published in Nucl. Instr. Meth. A, talk given at the "5th International Workshop on RPCs and Related Detectors", Bari (Italy) 199

Low noise cryogenic system for the measurement of Casimir energy in rigid cavities

We report on preliminary results on the measurement of variations of the Casimir energy in rigid cavities through its influence on the superconducting transition of in-cavity aluminium (Al) thin films. After a description of the experimental apparatus we report on a measurement made with thermal photons, discussing its implications for the zero-point photons case. Finally we show the preliminary results for the zero-point case.Comment: 9 pages, 7 figures, Talk given at QFEXT07 Conference in Liepzig: Quantum Field Theory Under the Influence of External Condition

Casimir apparatuses in a weak gravitational field

We review and assess a part of the recent work on Casimir apparatuses in the weak gravitational field of the Earth. For a free, real massless scalar field subject to Dirichlet or Neumann boundary conditions on the parallel plates, the resulting regularized and renormalized energy-momentum tensor is covariantly conserved, while the trace anomaly vanishes if the massless field is conformally coupled to gravity. Conformal coupling also ensures a finite Casimir energy and finite values of the pressure upon parallel plates. These results have been extended to an electromagnetic field subject to perfect conductor (hence idealized) boundary conditions on parallel plates, by various authors. The regularized and renormalized energy-momentum tensor has been evaluated up to second order in the gravity acceleration. In both the scalar and the electromagnetic case, studied to first order in the gravity acceleration, the theory predicts a tiny force in the upwards direction acting on the apparatus. This effect is conceptually very interesting, since it means that Casimir energy is indeed expected to gravitate, although the magnitude of the expected force makes it necessary to overcome very severe signal-modulation problems.Comment: 12 pages, prepared for the Fourth International Sakharov Conferenc

Investigating the Effects of Mutations on Protein Aggregation in the Cell

The conversion of peptides and proteins into highly ordered and intractable aggregates is associated with a range of debilitating human diseases and represents a widespread problem in biotechnology. Protein engineering studies carried out in vitro have shown that mutations promote aggregation when they either destabilize the native state of a globular protein or accelerate the conversion of unfolded or partially folded conformations into oligomeric structures. We have extended such studies to investigate protein aggregation in vivo where a number of additional factors able to modify dramatically the aggregation behavior of proteins are present. We have expressed, in Escherichia coli cells, an E. coli protein domain, HypF-N. The results for a range of mutational variants indicate that although mutants with a conformational stability similar to that of the wild-type protein are soluble in the E. coli cytosol, variants with single point mutations predicted to destabilize the protein invariably aggregate after expression. We show, however, that aggregation of destabilized variants can be prevented by incorporating multiple mutations designed to reduce the intrinsic propensity of the polypeptide chain to aggregate; in the cases discussed here, this is achieved by an increase in the net charge of the protein. These results suggest that the principles being established to rationalize aggregation behavior in vitro have general validity for situations in vivo where aggregation has both biotechnological and medical relevance

Positron localization effects on the Doppler broadening of the annihilation line: Aluminum as a case study

The coincidence Doppler broadening (CDB) technique is widely used to measure one-dimensional momentum distributions of annihilation photons, with the aim of obtaining information on the chemical environment of open-volume defects. However, the quantitative analysis of CDB spectra needs to include also purely geometrical effects. A demonstration is given here, on the basis of CDB spectra measured in quenched and in deformed pure aluminum. The comparison of the experimental results with ab initio computations shows that the observed differences come from the difference in free volume seen by positrons trapped in quenched-in vacancies or in vacancylike defects associated to dislocations. The computation reproduces accurately all details of CDB spectra, including the peak near the Fermi break, which is due to the zero-point motion of the confined positron.Peer reviewe

Prefibrillar amyloid protein aggregates share common features of cytotoxicity.

The intracellular free Ca(2+) concentration and redox status of murine fibroblasts exposed to prefibrillar aggregates of the HypF N-terminal domain have been investigated in vitro and in vivo using a range of fluorescent probes. Aggregate entrance into the cytoplasm is followed by an early rise of reactive oxygen species and free Ca(2+) levels and eventually by cell death. Such changes correlate directly with the viability of the cells and are not observed when cell are cultured in the presence of reducing agents or in Ca(2+)-free media. In addition, moderate cell stress following exposure to the aggregates was found to be fully reversible. The results show that the cytotoxicity of prefibrillar aggregates of HypF-N, a protein not associated with clinical disease, has the same fundamental origin as that produced by similar types of aggregates of proteins linked with specific amyloidoses. These findings suggest that misfolded proteinaceous aggregates stimulate generic cellular responses as a result of the exposure of regions of the structure (such as hydrophobic residues and the polypeptide main chain) that are buried in the normally folded proteins. They also support the idea that a higher number of degenerative pathologies than previously known might be considered as protein deposition diseases

THE PAST AND THE FUTURE OF DIRECT SEARCH OF GW FROM PULSARS IN THE ERA OF GW ANTENNAS

In this paper we will give an overview of the past and present status of Gravitational Wave (GW) research associated with pulsars, taking into account the target sensitivity achieved from interferometric laser GW antennas such as Tama, Geo, Ligo and Virgo. We will see that the upper limits obtained with searches for periodic GW begin to be astrophysically interesting by imposing non-trivial constraints on the structure and evolution of the neutron stars. We will give prospects for the future detection of pulsar GW signals, with Advanced Ligo and Advanced Virgo and future enhanced detectors, e.g. the Einstein Telescope

THE PAST AND THE FUTURE OF DIRECT SEARCH OF GW FROM PULSARS IN THE ERA OF GW ANTENNAS

In this paper we will give an overview of the past and present status of Gravitational Wave (GW) research associated with pulsars, taking into account the target sensitivity achieved from interferometric laser GW antennas such as Tama, Geo, Ligo and Virgo. We will see that the upper limits obtained with searches for periodic GW begin to be astrophysically interesting by imposing non-trivial constraints on the structure and evolution of the neutron stars. We will give prospects for the future detection of pulsar GW signals, with Advanced Ligo and Advanced Virgo and future enhanced detectors, e.g. the Einstein Telescope