Juicio final: A Definition of Human Existence

Juicio final: A Definition of Human Existenc

Marqués's La muerte no entrará en palacio and Dionysianism

Marqués's La muerte no entrará en palacio and Dionysianis

Analytical Psychology and Garro's Los pilares de doña Blanca

Analytical Psychology and Garro's Los pilares de doña Blanc

The relation between personal relative deprivation and the urge to gamble among gamblers is moderated by problem gambling severity: A meta-analysis

One psychosocial factor that has been identified to motivate gambling is personal relative deprivation (PRD), which refers to resentment stemming from the belief that one is deprived of a desired and deserved outcome compared to some referent. Although several lines of evidence point to a positive association between PRD and the urge to gamble, the factors that might moderate this relation have yet to be investigated. Through a quantitative research synthesis, we sought to test (a) the overall relation between PRD and gambling urges among people reporting recent gambling experience, and (b) whether this relation is moderated by problem gambling severity. Meta-analysis revealed that, overall, higher self-reported PRD was associated with stronger urges to gamble (r= .26). A meta-regression revealed that, across studies, the strength of this relation depended on problem gambling severity, such that the relation between PRD and gambling urges was stronger among samples higher in average problem gambling severity. This pattern was corroborated by an analysis of the aggregated individual participant data (N= 857), such that PRD predicted gambling urges only among participants higher in problem gambling severity. The potential practical implications and limitations of these results are discussed

Early Environmental Origins of Neurodegenerative Disease in Later Life

Parkinson disease (PD) and Alzheimer disease (AD), the two most common neurodegenerative disorders in American adults, are of purely genetic origin in a minority of cases and appear in most instances to arise through interactions among genetic and environmental factors. In this article we hypothesize that environmental exposures in early life may be of particular etiologic importance and review evidence for the early environmental origins of neurodegeneration. For PD the first recognized environmental cause, MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine), was identified in epidemiologic studies of drug abusers. Chemicals experimentally linked to PD include the insecticide rotenone and the herbicides paraquat and maneb; interaction has been observed between paraquat and maneb. In epidemiologic studies, manganese has been linked to parkinsonism. In dementia, lead is associated with increased risk in chronically exposed workers. Exposures of children in early life to lead, polychlorinated biphenyls, and methylmercury have been followed by persistent decrements in intelligence that may presage dementia. To discover new environmental causes of AD and PD, and to characterize relevant gene–environment interactions, we recommend that a large, prospective genetic and epidemiologic study be undertaken that will follow thousands of children from conception (or before) to old age. Additional approaches to etiologic discovery include establishing incidence registries for AD and PD, conducting targeted investigations in high-risk populations, and improving testing of the potential neurologic toxicity of chemicals

Exact calculation of the skyrmion lifetime in a ferromagnetic Bose condensate

The tunneling rate of a skyrmion in ferromagnetic spin-1/2 Bose condensates through an off-centered potential barrier is calculated exactly with the periodic instanton method. The prefactor is shown to depend on the chemical potential of the core atoms, at which level the atom tunnels. Our results can be readily extended to estimate the lifetime of other topological excitations in the condensate, such as vortices and monopoles.Comment: 16 pages, 4 figures, to appear Phys. Rev.

Ultrasound Mediated Gemcitabine Delivery Reduces the Normal-Tissue Toxicity of Chemoradiation Therapy in a Muscle-Invasive Bladder Cancer Model

Purpose: Chemoradiation is the standard of care in muscle-invasive bladder. While agents such as gemcitabine can enhance tumour radiosensitisation, their side effects can limit patient eligibility and treatment efficacy. Here we investigate ultrasound and microbubbles for targeting gemcitabine delivery to reduce normal tissue toxicity in a murine orthotopic MIBC model. Materials and Methods: CD1-nude mice were injected orthotopically with RT112 bladder tumour cells. Conventional chemoradiation involved injecting gemcitabine (10 mg/kg) before 6 Gy targeted irradiation of the bladder area using a Small Animal Radiation Research Platform (SARRP). Ultrasound-mediated gemcitabine delivery (10 mg/kg gemcitabine) involved either co-administration of microbubbles with gemcitabine or conjugating gemcitabine onto microbubbles followed by exposure to ultrasound (1.1 MHz centre frequency, 1 MPa peak negative pressure, 1% duty cycle and 0.5 Hz pulse repetition frequency), prior to SARRP irradiation. The effect of ultrasound and microbubbles alone was also tested. Tumour volumes were measured by 3D ultrasound imaging. Acute normal tissue toxicity from 12 Gy to the lower bowel area was assessed using an intestinal crypt assay in mice culled. 3.75 days post-treatment. Results: Significant tumour growth delay was observed with conventional chemoradiation and both microbubble groups (p Conclusions: Ultrasound and microbubbles offer a promising new approach for improving chemoradiation therapy in muscle-invasive bladder cancer, maintaining tumour growth delay but with reduced acute intestinal toxicity compared to conventional chemoradiation therapy.</p

Vacuum fluctuations in axion-dilaton cosmologies

We study axion-dilaton cosmologies derived from the low-energy string effective action. We present the classical homogeneous Friedmann-Robertson-Walker solutions and derive the semi-classical perturbation spectra in the dilaton, axion and moduli fields in the pre-Big Bang scenario. By constructing the unique S-duality invariant field perturbations for the axion and dilaton fields we derive S-duality invariant solutions, valid when the axion field is time-dependent as well as in a dilaton-vacuum cosmology. Whereas the dilaton and moduli fields have steep blue perturbation spectra (with spectral index n=4) we find that the axion spectrum depends upon the expansion rate of the internal dimensions (0.54<n<4) which allows scale-invariant (n=1) spectra. We note that for n<1 the metric is non-singular in the conformal frame in which the axion is minimally coupled.Comment: LaTeX, 23 pages plus 6 figures, minor typos corrected and references updated. To appear in Phys Rev

One-Loop Superstring Cosmology and the Non-Singular Universe

We study the cosmological implications of the one-loop terms in the string expansion. In particular, we find non-singular solutions which interpolate between a contracting universe and an expanding universe, and show that these solutions provide a mechanism for removing the initial conditions problem peculiar to spatially closed FRW cosmologies. In addition, we perform numerical calculations to show that the non-singular cosmologies do not require a careful choice of initial conditions, and estimate the likely magnitude of higher order terms in the string expansion.Comment: 19 pages, 3 figures (postscript), Latex2e, discussion of curvature invariants added. To appear in Phys. Rev.