427 research outputs found
Measuring the Speed of Sound of Quintessence
Quintessence, a time-varying energy component that may account for the accelerated expansion of the universe, can be characterized by its equation of state and sound speed. In this paper, we show that if the quintessence density is at least one percent of the critical density at the surface of last scattering the cosmic microwave background anisotropy can distinguish between models whose sound speed is near the speed of light versus near zero, which could be useful in distinguishing competing candidates for dark energy
Probing hyperbolic polaritons using infrared attenuated total reflectance micro-spectroscopy
Hyperbolic polariton modes are highly appealing for a broad range of
applications in nanophotonics, including surfaced enhanced sensing,
sub-diffractional imaging and reconfigurable metasurfaces. Here we show that
attenuated total reflectance micro-spectroscopy (ATR) using standard
spectroscopic tools can launch hyperbolic polaritons in a Kretschmann-Raether
configuration. We measure multiple hyperbolic and dielectric modes within the
naturally hyperbolic material hexagonal boron nitride as a function of
different isotopic enrichments and flake thickness. This overcomes the
technical challenges of measurement approaches based on nanostructuring, or
scattering scanning nearfield optical microscopy. Ultimately, our ATR approach
allows us to compare the optical properties of small-scale materials prepared
by different techniques systematicallyComment: 13 pages 4 figure
Identification of sex hormone-binding globulin in the human hypothalamus
Gonadal steroids are known to influence hypothalamic functions through both genomic and non-genomic pathways. Sex hormone-binding globulin ( SHBG) may act by a non-genomic mechanism independent of classical steroid receptors. Here we describe the immunocytochemical mapping of SHBG-containing neurons and nerve fibers in the human hypothalamus and infundibulum. Mass spectrometry and Western blot analysis were also used to characterize the biochemical characteristics of SHBG in the hypothalamus and cerebrospinal fluid (CSF) of humans. SHBG-immunoreactive neurons were observed in the supraoptic nucleus, the suprachiasmatic nucleus, the bed nucleus of the stria terminalis, paraventricular nucleus, arcuate nucleus, the perifornical region and the medial preoptic area in human brains. There were SHBG-immunoreactive axons in the median eminence and the infundibulum. A partial colocalization with oxytocin could be observed in the posterior pituitary lobe in consecutive semithin sections. We also found strong immunoreactivity for SHBG in epithelial cells of the choroid plexus and in a portion of the ependymal cells lining the third ventricle. Mass spectrometry showed that affinity-purified SHBG from the hypothalamus and choroid plexus is structurally similar to the SHBG identified in the CSF. The multiple localizations of SHBG suggest neurohypophyseal and neuroendocrine functions. The biochemical data suggest that CSF SHBG is of brain rather than blood origin. Copyright (c) 2005 S. Karger AG, Base
Gaucher Disease Glucocerebrosidase and α-Synuclein Form a Bidirectional Pathogenic Loop in Synucleinopathies
SummaryParkinson's disease (PD), an adult neurodegenerative disorder, has been clinically linked to the lysosomal storage disorder Gaucher disease (GD), but the mechanistic connection is not known. Here, we show that functional loss of GD-linked glucocerebrosidase (GCase) in primary cultures or human iPS neurons compromises lysosomal protein degradation, causes accumulation of α-synuclein (α-syn), and results in neurotoxicity through aggregation-dependent mechanisms. Glucosylceramide (GlcCer), the GCase substrate, directly influenced amyloid formation of purified α-syn by stabilizing soluble oligomeric intermediates. We further demonstrate that α-syn inhibits the lysosomal activity of normal GCase in neurons and idiopathic PD brain, suggesting that GCase depletion contributes to the pathogenesis of sporadic synucleinopathies. These findings suggest that the bidirectional effect of α-syn and GCase forms a positive feedback loop that may lead to a self-propagating disease. Therefore, improved targeting of GCase to lysosomes may represent a specific therapeutic approach for PD and other synucleinopathies
Discovery and Validation of Kepler-452b: A 1.6-Re Super Earth Exoplanet in the Habitable Zone of a G2 Star
We report on the discovery and validation of Kepler-452b, a transiting planet
identified by a search through the 4 years of data collected by NASA's Kepler
Mission. This possibly rocky 1.63 R planet orbits
its G2 host star every 384.843 days, the longest orbital
period for a small (R < 2 R) transiting exoplanet to date. The
likelihood that this planet has a rocky composition lies between 49% and 62%.
The star has an effective temperature of 575785 K and a log g of
4.320.09. At a mean orbital separation of 1.046 AU,
this small planet is well within the optimistic habitable zone of its star
(recent Venus/early Mars), experiencing only 10% more flux than Earth receives
from the Sun today, and slightly outside the conservative habitable zone
(runaway greenhouse/maximum greenhouse). The star is slightly larger and older
than the Sun, with a present radius of 1.11 R and an
estimated age of 6 Gyr. Thus, Kepler-452b has likely always been in the
habitable zone and should remain there for another 3 Gyr.Comment: 19 pages, 16 figure
Terrestrial Planet Occurrence Rates for the Kepler GK Dwarf Sample
We measure planet occurrence rates using the planet candidates discovered by
the Q1-Q16 Kepler pipeline search. This study examines planet occurrence rates
for the Kepler GK dwarf target sample for planet radii, 0.75<Rp<2.5 Rearth, and
orbital periods, 50<Porb<300 days, with an emphasis on a thorough exploration
and identification of the most important sources of systematic uncertainties.
Integrating over this parameter space, we measure an occurrence rate of F=0.77
planets per star, with an allowed range of 0.3<F<1.9. The allowed range takes
into account both statistical and systematic uncertainties, and values of F
beyond the allowed range are significantly in disagreement with our analysis.
We generally find higher planet occurrence rates and a steeper increase in
planet occurrence rates towards small planets than previous studies of the
Kepler GK dwarf sample. Through extrapolation, we find that the one year
orbital period terrestrial planet occurrence rate, zeta_1=0.1, with an allowed
range of 0.01<zeta_1<2, where zeta_1 is defined as the number of planets per
star within 20% of the Rp and Porb of Earth. For G dwarf hosts, the zeta_1
parameter space is a subset of the larger eta_earth parameter space, thus
zeta_1 places a lower limit on eta_earth for G dwarf hosts. From our analysis,
we identify the leading sources of systematics impacting Kepler occurrence rate
determinations as: reliability of the planet candidate sample, planet radii,
pipeline completeness, and stellar parameters.Comment: 19 Pages, 17 Figures, Submitted ApJ. Python source to support Kepler
pipeline completeness estimates available at
http://github.com/christopherburke/KeplerPORTs
Planetary Candidates Observed by Kepler. VII. The First Fully Uniform Catalog Based on The Entire 48 Month Dataset (Q1-Q17 DR24)
We present the seventh Kepler planet candidate catalog, which is the first to
be based on the entire, uniformly processed, 48 month Kepler dataset. This is
the first fully automated catalog, employing robotic vetting procedures to
uniformly evaluate every periodic signal detected by the Q1-Q17 Data Release 24
(DR24) Kepler pipeline. While we prioritize uniform vetting over the absolute
correctness of individual objects, we find that our robotic vetting is overall
comparable to, and in most cases is superior to, the human vetting procedures
employed by past catalogs. This catalog is the first to utilize artificial
transit injection to evaluate the performance of our vetting procedures and
quantify potential biases, which are essential for accurate computation of
planetary occurrence rates. With respect to the cumulative Kepler Object of
Interest (KOI) catalog, we designate 1,478 new KOIs, of which 402 are
dispositioned as planet candidates (PCs). Also, 237 KOIs dispositioned as false
positives (FPs) in previous Kepler catalogs have their disposition changed to
PC and 118 PCs have their disposition changed to FP. This brings the total
number of known KOIs to 8,826 and PCs to 4,696. We compare the Q1-Q17 DR24 KOI
catalog to previous KOI catalogs, as well as ancillary Kepler catalogs, finding
good agreement between them. We highlight new PCs that are both potentially
rocky and potentially in the habitable zone of their host stars, many of which
orbit solar-type stars. This work represents significant progress in accurately
determining the fraction of Earth-size planets in the habitable zone of
Sun-like stars. The full catalog is publicly available at the NASA Exoplanet
Archive.Comment: Accepted to the Astrophysical Journal Supplement Series. 30 pages, 9
figures, 7 tables. We make the DR24 robovetter decision code publicly
available at http://github.com/JeffLCoughlin/robovetter, with input and
output examples provided using the same data as contained in the full paper's
table
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