Plantaris excision reduces pain in Mid-portion Achilles tendinopathy even in the absence of plantaris tendinosis

Background It is becoming increasingly apparent that the plantaris can contribute to symptoms in at least a subset of patients with mid-portion Achilles tendinopathy. However the nature of its involvement remains unclear. Hypothesis / Purpose To determine whether excised plantaris tendons from patients with mid-portion Achilles tendinopathy display tendinopathic changes and whether the presence of such changes affect clinical outcomes. Methods Sixteen plantaris tendons patients with mid-portion Achilles tendinopathy recalcitrant to conservative management underwent histological examination for the presence of tendinopathic changes. All patients had imaging to confirm the presence of the plantaris tendon adherent to or invaginated into the focal area of Achilles tendinosis. Visual analogue scores (VAS) and foot and ankle outcome scores (FAOS) were recorded pre and post-operatively. Results Sixteen patients (mean age 26.2; 18-47 years) underwent surgery with a mean follow-up of 14 months (range 6-20 months). The plantaris tendon was histologically normal in 13/16 cases (81%). Inflammatory changes in the loose peritendinous connective tissue surrounding the plantaris tendon were evident in all cases. There was significant improvement in mean VAS scores (p<0.05) and all domains of the FAOS post-operatively (p<0.05). Conclusions The absence of any tendinopathic changes in the excised plantaris of 13 patients who clinically improved suggests plantaris involvement with Achilles tendinopathy may not yet be fully understood and supports the concept that this may be a compressive or a frictional phenomenon rather than purely tendinopathic. Clinical Relevance There is increasing evidence to support that the excision of plantaris results in improved clinical outcomes in a sub-set of patients with mid-portion Achilles tendinopathy. Prior findings have reported that excised plantaris tendons from these patients display tendinopathic changes. However these findings suggest the role of plantaris in the pathology of these patients could be biomechanical since patients improved even when the excised plantaris was not tendinopathic

Responsiveness of bovine cumulus-oocyte-complexes (COC) to porcine and recombinant human FSH, and the effect of COC quality on gonadotropin receptor and Cx43 marker gene mRNAs during maturation in vitro

Substantially less development to the blastocyst stage occurs in vitro than in vivo and this may be due to deficiencies in oocyte competence. Although a large proportion of bovine oocytes undergo spontaneous nuclear maturation, less is known about requirements for proper cytoplasmic maturation. Commonly, supraphysiological concentrations of FSH and LH are added to maturation media to improve cumulus expansion, fertilization and embryonic development. Therefore, various concentrations of porcine FSH (pFSH) and recombinant human FSH (rhFSH) were investigated for their effect on bovine cumulus expansion in vitro. Expression of FSHr, LHr and Cx43 mRNAs was determined in cumulus-oocyte complexes to determine whether they would be useful markers of oocyte competence. In serum-free media, only 1000 ng/ml pFSH induced marked cumulus expansion, but the effect of 100 ng/ml pFSH was amplified in the presence of 10% serum. In contrast, cumulus expansion occurred with 1 ng/ml rhFSH in the absence of serum. FSHr mRNA was highest at 0–6 h of maturation, then abundance decreased. Similarly, Cx43 mRNA expression was highest from 0–6 h but decreased by 24 h of maturation. However, the relative abundance of LHr mRNA did not change from 6–24 h of maturation. Decreased levels of FSHr, LHr and Cx43 mRNAs were detected in COCs of poorer quality. In conclusion, expansion of bovine cumulus occurred at low doses of rhFSH in serum-free media. In summary, FSHr, LHr and Cx43 mRNA abundance reflects COC quality and FSHr and Cx43 mRNA expression changes during in vitro maturation; these genes may be useful markers of oocyte developmental competence

La m?sica como estrategia dinamizadora para facilitar los procesos de aprendizaje en la educaci?n inicial

65 P?ginasRecurso Electr?nicoEl proyecto titulado la m?sica como estrategia dinamizadora para facilitar los procesos de aprendizaje en el nivel de transici?n de la Instituci?n Educativa Santa Teresa de Jes?s, se desarroll? con el ?nimo de dar soluci?n a las situaciones que se presentan respecto a la falta de motivaci?n e inter?s de los infantes en las actividades escolares, pues estas son rutinarias. Durante la ejecuci?n de este proyecto se hizo hincapi? en la importancia que tiene el implementar la m?sica como estrategia dinamizadora para despertar el inter?s, la motivaci?n y potencializar los procesos de aprendizaje en los infantes, la cual fortalece las dimensiones del desarrollo y potencializa las inteligencias m?ltiples, la creatividad, adem?s del gran aporte que esta le brinda al individuo desde todos sus ?mbitos de formaci?n. La preocupaci?n por la falta de motivaci?n e inter?s en los ni?os, fue lo que origin? la necesidad de implementar el presente proyecto, con el objetivo de despertar el gusto y el disfrute a trav?s de la m?sica como estrategia pedag?gica para dinamizar sus procesos de aprendizaje. Por ende este proyecto refleja el desarrollo del proceso de investigaci?n formativa, desde el enfoque metodol?gico etnogr?fico y de investigaci?n, el cual dio lugar a plantear una estrategia de intervenci?n siendo ben?fico para el desarrollo educativo en las ni?as de preescolar de la Instituci?n Educativa Santa Teresa de Jes?s.ABSTRACT. The project titled ?The Music? as a revitalizing strategy; intended to facilitate the learning process in a transition level in the educational institution Santa Teresa de Jesus. This project aims to give alternative solutions to no motivation or lack of interest in scholar activities done by children. This project emphasizes in the music as a revitalizing strategy to arouse the interest and motivation in learning process. Music, also strengthens dimensions of development, potentiates multiple intelligences, creativity and many other learning areas. The concern about the lack of motivation and interest of children, led to the need to implement this project. This project aims to arouse the enjoyment of scholar activities, through the music as a pedagogical strategy to boost their learning processes. Therefore this project reflects the development of formative research, from ethnographic research and methodological approach. This project proposes an intervention strategy that shows benefits for educational development in preschool girls of educational institution Santa Teresa de Jes?s.INTRODUCCI?N 13 1. PLANTEAMIENTO DEL PROBLEMA 15 1.1 DESCRIPCI?N DEL PROBLEMA 15 1.2 FORMULACI?N DEL PROBLEMA 16 2. OBJETIVOS 17 2.1 OBJETIVO GENERAL 17 2.2 OBJETIVOS ESPEC?FICOS 17 3. JUSTIFICACI?N 18 4. MARCO REFERENCIAL 20 4.1 ANTECEDENTES 20 4.2 MARCO TEORICO 23 4.2.1 La m?sica seg?n Willems, Orff, Kodally 23 4.2.2 Aprendizaje Significativo seg?n Ausbel 26 4.3 MARCO CONTEXTUAL 27 4.4 MARCO LEGAL 29 5. METODOLOGIA 38 5.1 ESTRUCTURA METODOL?GICA 38 5.1.1 Descripci?n Fase 1: Caracterizaci?n. 40 5.1.2 Descripci?n Fase 2: Intervenci?n 41 5.2 AN?LISIS DE RESULTADOS 43 5.2.1 Validez y confiabilidad 43 5.3 EVALUACI?N Y SEGUIMIENTO 43 5.3.1 Fase 1 Caracterizaci?n de las pr?cticas que se ejercen y de los discursos que circulan sobre la educaci?n de los ni?os y ni?as menores de 7 a?os 44 5.3.2 Fase 2. Los sentidos pedag?gicos de los proyectos de intervenci?n 44 6. EL PROYECTO DE INTERVENCION 46 6.1 ESQUEMA GENERAL DEL PROYECTO 46 6.2 ACTIVIDADES INTEGRADORAS DEL PROYECTO DE INTERVENCION 47 6.2.1 Actividades integradoras para directivos y docentes. 47 6.2.2 Actividades integradoras para padres y familia. 48 6.2.3 Actividades integradoras para ni?as en el PPA. 50 6.3 EXPERIENCIA PEDAGOGICA 51 7. CONCLUSIONES 54 RECOMENDACIONES 56 REFERENCIAS 57 ANEXOS 5

BigraphER: rewriting and analysis engine for bigraphs

BigraphER is a suite of open-source tools providing an effi- cient implementation of rewriting, simulation, and visualisation for bigraphs, a universal formalism for modelling interacting systems that evolve in time and space and first introduced by Milner. BigraphER consists of an OCaml library that provides programming interfaces for the manipulation of bigraphs, their constituents and reaction rules, and a command-line tool capable of simulating Bigraphical Reactive Systems (BRSs) and computing their transition systems. Other features are native support for both bigraphs and bigraphs with sharing, stochastic reaction rules, rule priorities, instantiation maps, parameterised controls, predicate checking, graphical output and integration with the probabilistic model checker PRISM

Estrategia l?dica pedag?gica para el mejoramiento de la convivencia escolar en el grado octavo de la Instituci?n Educativa Manuela Oma?a de Flandes, Tolima

116 p. Recurso Electr?nicoEl presente trabajo de investigaci?n aborda la importancia que tiene la convivencia escolar y los procesos educativos. Tiene como punto de partida el resultado de diferentes investigaciones, que indican la pertinencia de incluir actividades l?dicas, recreativas y ecol?gicas a los proyectos pedag?gicos; esta inclusi?n constituye un aporte para las transformaciones educativas. La investigaci?n se realiz? en la instituci?n Educativa Manuela Oma?a del municipio de Flandes Tolima, con los estudiantes del grado octavo y tiene como objetivo primordial mejorar la convivencia y las relaciones interpersonales en la instituci?n. La estrategia metodol?gica fue cualitativa y se utilizaron t?cnicas de recolecci?n de informaci?n mixta, las cuales permitieron abordar factores como capacitaci?n docente, competencias ecol?gicas, actividades l?dicas, trabajo en grupo y el desarrollo de la propuesta pedag?gica, la investigaci?n se ha desarrollado durante un periodo de 12 meses, los datos fueron analizados de acuerdo con la fundamentaci?n te?rica, y por medio de un programa estad?stico. El docente en su papel de orientador debe formar estudiantes ?ntegros, en valores y que sean ?tiles para la sociedad. Una manera importante de alcanzar estos logros es ense??ndoles buenas relaciones interpersonales y a utilizar el di?logo como herramienta para abrirse fronteras. Palabras claves: Ambiente Escolar, Manual de Convivencia, Sentido de Pertenencia, relaciones Humanas.The present research work addresses the importance of school coexistence and educational processes. Its starting point is the result of different investigations, which indicate the relevance of including leisure, recreational and ecological activities to pedagogical projects; this inclusion constitutes a contribution for educational transformations. The research was conducted in the Manuela Oma?a Educational Institution of the municipality of Flanders Tolima, with eighth grade students and its main objective is to improve coexistence and interpersonal relationships in the institution. The methodological strategy was qualitative and mixed information collection techniques were used, which allowed to address factors such as teacher training, ecological skills, play activities, group work and the development of the pedagogical proposal, the research was developed during a period of 12 months, the data were analyzed according to the theoretical foundation, and by means of a statistical program. The teacher in his role as counselor must train students in integrity, in values and that are useful for society. An important way to achieve these achievements is to teach them good interpersonal relationships and to use dialogue as a tool to open borders. Keywords: School Environment, Manual of Coexistence, Sense of Belonging, Human Relations

Sistema de informaci?n web y consulta m?vil para consultorio m?dico independiente de salud ocupacional Doctor Gabriel Meneses de la ciudad de Ibagu?

115 p. Recurso Electr?nicoEn Colombia uno de los requisitos para poder acceder a un empleo son los ex?menes que se realizan en las diferentes oficinas de salud ocupacional, pero esto resulta ser algo molesto tanto para quienes asisten a hacerse los ex?menes como para quienes los realizan, para asegurarse de no tardar demasiado tiempo dentro de los consultorios se tiene que llegar en ayunas y temprano. Pero llevar todos los procesos en archivo f?sico hace que este proceso sea largo y desordenado, en algunos casos mientras se es atendido por un especialista es solicitado en otro consultorio, y el hecho de trasladar los diferentes formatos y resultados de consultorio a consultorio ocasiona que la espera sea m?s larga y en ocasiones que se extrav?en algunos documentos, esto ocasiona que la tensi?n afecte a los clientes y a profesionales de la salud quienes al estar sometidos a estas situaciones genera estr?s en ellos, lo cual afecta su juicio profesional al querer hacer todo m?s r?pido. Al llevar estos procesos mediante un software que use una base de datos y pueda llevar los archivos a internet de manera segura, se aumentar?a no solamente la velocidad de la atenci?n sino tambi?n la calidad del servicio y la calidad de vida de los pacientes al poder acceder a sus nuevos empleos, ya que por lo general los diferentes formatos son extensos y repetitivos en cada consulta al almacenar los datos personales de cada cliente y su respectivo historial hace que la atenci?n sea m?s r?pida y que se pueda atender a mucha m?s gente, y teniendo los datos en internet se pueden realizar consultas de los ex?menes y crear un informe en pdf para ser enviado por correo desde cualquier lugar sin necesidad de acercarse a la oficina a revisar archivos, de esto se tratar este proyecto, de mejorar la calidad de vida y efectividad del consultorio.In Colombia one of the requirements for access to employment are the tests done in different surgery occupational health, but this turns out to be a nuisance both for those attending to get tested as those performing, to make sure no It takes too long in clinics have to get fasting and early. But bringing all processes in physical file makes this process long and messy, in some cases while it is staffed by a specialist is requested in another office, and the fact of moving the different formats and results of surgery to surgery, causes the expected to be longer and sometimes misplaced some documents, this causes tension and affect the health professional clients who when subjected to these situations creates stress in them which affect their professional judgment to want to do everything faster . By bringing these processes using software that use a database and can carry Internet files safely, not only will increase the speed of attention but also the quality of service and the quality of life for patients to gain access their new jobs because usually different formats are extensive and repeated at every visit to the store the personal data of each client and their respective history makes the care more quickly and you can meet more people, and having internet data queries can be performed examinations and create a PDF report to be mailed from anywhere without having to approach the office to review files, that the project to improve the quality of life and effectiveness of the office are treated. Keywords: software, database, occupational health, surgery

Trend-based analysis of a population model of the AKAP scaffold protein

We formalise a continuous-time Markov chain with multi-dimensional discrete state space model of the AKAP scaffold protein as a crosstalk mediator between two biochemical signalling pathways. The analysis by temporal properties of the AKAP model requires reasoning about whether the counts of individuals of the same type (species) are increasing or decreasing. For this purpose we propose the concept of stochastic trends based on formulating the probabilities of transitions that increase (resp. decrease) the counts of individuals of the same type, and express these probabilities as formulae such that the state space of the model is not altered. We define a number of stochastic trend formulae (e.g. weakly increasing, strictly increasing, weakly decreasing, etc.) and use them to extend the set of state formulae of Continuous Stochastic Logic. We show how stochastic trends can be implemented in a guarded-command style specification language for transition systems. We illustrate the application of stochastic trends with numerous small examples and then we analyse the AKAP model in order to characterise and show causality and pulsating behaviours in this biochemical system