783 research outputs found
Efficient C-Phase gate for single-spin qubits in quantum dots
Two-qubit interactions are at the heart of quantum information processing.
For single-spin qubits in semiconductor quantum dots, the exchange gate has
always been considered the natural two-qubit gate. The recent integration of
magnetic field or g-factor gradients in coupled quantum dot systems allows for
a one-step, robust realization of the controlled phase (C-Phase) gate instead.
We analyze the C-Phase gate durations and fidelities that can be obtained under
realistic conditions, including the effects of charge and nuclear field
fluctuations, and find gate error probabilities of below 10-4, possibly
allowing fault-tolerant quantum computation.Comment: 5 pages, 3 figure
Mechanical cleaning of graphene
Contamination of graphene due to residues from nanofabrication often
introduces background doping and reduces charge carrier mobility. For samples
of high electronic quality, post-lithography cleaning treatments are therefore
needed. We report that mechanical cleaning based on contact mode AFM removes
residues and significantly improves the electronic properties. A mechanically
cleaned dual-gated bilayer graphene transistor with hBN dielectrics exhibited a
mobility of ~36,000 cm2/Vs at low temperature.Comment: 4 pages, 4 figure
Mechanical properties of flexible film based on starch and passion fruit mesocarp flour added of nanoparticles.
Development and characterization of flexible film based on starch and passion fruit mesocarp flour with nanoparticles.
CITED2 and the modulation of the hypoxic response in cancer
CITED2 (CBP/p300-interacting transactivator with Glu/Asp-rich C-terminal domain, 2) is a ubiquitously expressed protein exhibiting a high affinity for the CH1 domain of the transcriptional co-activators CBP/p300, for which it competes with hypoxia-inducible factors (HIFs). CITED2 is particularly efficient in the inhibition of HIF-1α-dependent transcription in different contexts, ranging from organ development and metabolic homeostasis to tissue regeneration and immunity, being also potentially involved in various other physiological processes. In addition, CITED2 plays an important role in inhibiting HIF in some diseases, including kidney and heart diseases and type 2-diabetes. In the particular case of cancer, CITED2 either functions by promoting or suppressing cancer development depending on the context and type of tumors. For instance, CITED2 overexpression promotes breast and prostate cancers, as well as acute myeloid leukemia, while its expression is downregulated to sustain colorectal cancer and hepatocellular carcinoma. In addition, the role of CITED2 in the maintenance of cancer stem cells reveals its potential as a target in non-small cell lung carcinoma and acute myeloid leukemia, for example. But besides the wide body of evidence linking both CITED2 and HIF signaling to carcinogenesis, little data is available regarding CITED2 role as a negative regulator of HIF-1α specifically in cancer. Therefore, comprehensive studies exploring further the interactions of these two important mediators in cancer-specific models are sorely needed and this can potentially lead to the development of novel targeted therapies.info:eu-repo/semantics/publishedVersio
Permeabilidade ao vapor de água e hidrofobicidade de filmes de farinha do mesocarpo de maracujá e amido.
Cost Evaluation During 2002 in a Medicine/Immunodeficiency Hospital Outpatient Attendance
O consumo de recursos económicos com a Saúde é uma preocupação constante dos governantes, dos administradores hospitalares e também dos profissionais de Saúde, sendo a área
do seguimento/tratamento dos doentes infectados pelo VÃrus da Imunodeficiência Humana (VIH) apontada como uma das que
mais recursos consome.
Os AA procuraram, pela avaliação dos doentes seguidos na Consulta de Medicina/Imunodeficiência do Hospital de Santo António dos Capuchos durante o perÃodo de um ano (2002), aferir de forma concreta os custos de funcionamento da mesma.
Material e Métodos: Foram avaliados os utentes da Consulta de Medicina/Imunodeficiência do Hospital de Santo António dos Capuchos (HSAC) que nela compareceram, pelo menos, duas vezes durante o ano de 2002.
O cálculo dos custos das consultas e dos exames complementares de diagnóstico baseou-se nos valores definidos nos Grupos
de Diagnósticos Homogéneos (GDHs).
O custo da terapêutica anti-retroviral foi calculado segundo os valores que nos foram fornecidos pela Farmácia do Hospital e
assumindo o fornecimento mensal da mesma.
Resultados: Foram avaliados 107 doentes correspondendo a 498 consultas (€11.424). Fizeram-se 244 determinações de carga
viral €(24.321) e 245 estudos de subpopulações linfocitárias
(€15.445). As restantes análises custaram €36.586. Dos 107 doentes, 85 estavam sob terapêutica anti-retroviral, com 3 ou 4
fármacos, tendo sido gasto, em média e por doente, €7.122.
Foi necessário o internamento de 18 doentes, num total de 219 dias (€41.699).
Conclusão: O custo médio anual por doente foi de €6.408
Dyslipidaemia and Undernutrition in Children from Impoverished Areas of Maceió, State of Alagoas, Brazil
Chronic undernutrition causes reduced growth and endocrine adaptations in order to maintain basic life processes. In the present study, the biochemical profiles of chronically undernourished children were determined in order to test the hypothesis that chronic undernutrition also causes changes in lipid profile in pre-school children. The study population comprised 80 children aged between 12 and 71 months, including 60 with moderate undernutrition [height-for-age Z (HAZ) scores ≤ −2 and > −3] and 20 with severe undernutrition (HAZ scores ≤ −3). Socioeconomic, demographic and environmental data were obtained by application of a questionnaire, and anthropometric measurements and information relating to sex, age and feeding habits were collected by a trained nutritionist. Blood samples were analysed for haemoglobin, vitamin A, insulin-like growth factor 1 (IGF-1) and serum lipids, while cortisol was assayed in the saliva. Faecal samples were submitted to parasitological investigation. Analysis of variance and χ2 methods were employed in order to select the variables that participated in the multivariate logistic regression analysis. The study population was socioeconomically homogeneous, while the lack of a treated water supply was clearly associated with the degree of malnutrition. Most children were parasitised and anaemia was significantly more prevalent among the severely undernourished. Levels of IGF-1 decreased significantly with increasing severity of undernutrition. Lipid analysis revealed that almost all of the children had dyslipidemia, while low levels of high-density lipoprotein were associated with the degree of undernutrition. It is concluded that chronic malnutrition causes endocrine changes that give rise to alterations in the metabolic profile of pre-school children
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