347 research outputs found
Giant phonon anomalies in the pseudo-gap phase of TiOCl
We report infrared and Raman spectroscopy results of the spin-1/2 quantum
magnet TiOCl. Giant anomalies are found in the temperature dependence of the
phonon spectrum, which hint to unusual coupling of the electronic degrees of
freedom to the lattice. These anomalies develop over a broad temperature
interval, suggesting the presence of an extended fluctuation regime. This
defines a pseudo-gap phase, characterized by a local spin-gap. Below 100 K a
dimensionality cross-over leads to a dimerized ground state with a global
spin-gap of about 2~430 K.Comment: 4 pages, 3 figures, for further information see
http://www.peter-lemmens.d
The antibody-drug conjugate loncastuximab tesirine for the treatment of diffuse large B-cell lymphoma
Diffuse large B-cell lymphoma (DLBCL) is a heterogenous subtype of non-Hodgkin lymphoma. Relapsed/refractory disease represents remains an unmet medical need, despite the introduction of novel cellular and targeted therapies. Loncastuximab tesirine is a cluster of differentiation19-targeting antibody-drug conjugate approved by the US Food and Drug Administration for relapsed DLBCL after 2 lines of systemic therapy based on a trial showing a 48.3% overall response rate. The spectrum of its clinical applications is expanding and is now being tested in other B-cell malignancies
Optical Properties and Correlation Effects in NaxCoO2
We have calculated the optical spectra of NaCoO for =0.3, 0.5,
and 0.7 within the LDA. We compare our results to available experimental data
and show that the important features and trends are reproduced well, but there
is a nearly uniform shift of peak positions and poor agreement in intensities.
We show, through application of a simple model, that these differences can be
attributed to overhybridization between Co and O orbitals and spin fluctuations
which renormalize the bandwidth. Applying the LDA+U procedure shifts the
optical peaks further from their experimental locations, indicating that this
method of incorporating correlation effects is ill-suited for the case NaxCoO2
Release of Palladium from Biomechanical Prostheses in Body Fluids Can Induce or Support PD-Specific IFNγ T Cell Responses and the Clinical Setting of a Palladium Hypersensitivity:
The increased use of Palladium (Pd) for biomedical applications, which has more than doubled in the last ten years, appears to be associated with an increased frequency of adverse reactions to Pd. The aim of this study is to investigate the relationship between the implant of a biomechanical apparatus containing Pd and the setting of a hypersensitivity to Pd by determining the levels of the metal released in biological fluids, assessing the effects of Pd on peripheral blood mononuclear cell (PBMC) cytokine production and exploring the clinical setting of skin sensitization. Of a total of 3,093 subjects examined in 2006, sensitization to Pd alone or in association with nickel (Ni) was observed in 1.6% and 13.03% of the individuals, respectively. Of these, a group of six subjects positive to Pd and negative to Ni at patch testing were selected on the basis of the oral clinical symptoms in order to measure both the levels of Pd in biological fluids and the degradation of the dental prostheses. Specific Pd measurements were carried out on salivary fluid, urine and serum samples by High Resolution Inductively Coupled Plasma-Mass Spectrometry. In addition, the degradation of the dental prostheses was assessed by both a "leaching test" and an analysis of the micro morphology of orthodontic prostheses. The induction of IFN-γ production by Pd was assessed in PBMC by the ELISpot assay. Skin sensitization to Pd was evaluated by patch testing and clinical examination. Ten healthy subjects were comparatively tested as controls. We found a specific induction of an IFN-γ response by Pd in PBMC collected from all the subjects positive to Pd at patch testing. On the contrary, control subjects did not show any response to Pd as assessed by IFN-γ ELISpot assay or by skin testing. Remarkably, the levels of Pd in all biological samples (saliva, sera, urine) were significantly higher in Pd-sensitized patients than in those collected from controls, reaching the highest concentrations in the urine. The leaching studies gave additional evidence that the dental appliances can release measurable levels of Pd in saliva. Oral clinical symptoms in patients with Pd dental prostheses were associated with measurable levels of Pd in the biological fluids, the induction of Pd-specific IFN-γ responses in PBMC and the clinical evidence of skin sensitization to Pd. These data suggest that dental appliances may represent an active source of Pd in the body, and this, in turn, can favour the clinical setting of a hypersensitivity to this metal
Infrared optical properties of the spin-1/2 quantum magnet
We report results on the electrodynamic response of , a
low-dimensional spin-1/2 quantum magnet that shows a spin gap formation for
T= 67 . The Fano-like shape of a few selected infrared active
phonons suggests an interaction between lattice vibrations and a continuum of
low frequency (spin) excitations. The temperature dependence of the phonon mode
parameters extends over a broad temperature range well above ,
indicating the presence of an extended fluctuation regime. In the temperature
interval between 200 and there is a progressive dimensionality
crossover (from two to one), as well as a spectral weight shift from low
towards high frequencies. This allows us to identify a characteristic energy
scale of about 430 , ascribed to a pseudo spin-gap
Infrared Conductivity and Charge Ordering in NaCoO2
The infrared conductivity of NaxCoO2 is studied as a function of doping and
temperature for x between 0.5 and 1. Charge localization in CoO2 layers shows
up through a far-infrared peak (FIP) in the infrared conductivity which
coexists with a small Drude contribution. Long-range ordering at x = 0.5 is
confirmed to create a far-infrared gap, in addition to the FIP. At high x, the
formation of a Spin-Density Wave reported below 22 K dramatically shifts the
FIP to higher energy when x is incommensurate with the lattice, indicating an
abrupt deepening of the localizing potential. The in-plane E1u phonon lifetime
is shown to be sensitive to both "freezing" and ordering of the mobile Na+
ions. A comparison with the behavior of the FIP shows that such "freezing" is
not the only origin of charge localization in the CoO layers.Comment: 7 pages, 4 figure
Spin gap formation in the quantum spin systems TiOX, X=Cl and Br
In the layered quantum spin systems TiOCl and TiOBr the magnetic
susceptibility shows a very weak temperature dependence at high temperatures
and transition-induced phenomena at low temperatures. There is a clear
connection of the observed transition temperatures to the distortion of the
octahedra and the layer separation. Band structure calculations point to a
relation of the local coordinations and the dimensionality of the magnetic
properties. While from magnetic Raman scattering only a small decrease of the
magnetic exchange by -5-10% is derived comparing TiOCl with TiOBr, the
temperature dependence of the magnetic susceptibility favors a much bigger
change.Comment: 5 figures, 15 pages, further information see
http://www.peter-lemmens.d
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