42,101 research outputs found
Microscopic origin of light emission in Al_yGa_{1-y}N/GaN superlattice: Band profile and active site
We present first-principles calculations of AlGaN/GaN superlattice,
clarifying the microscopic origin of the light emission and revealing the
effect of local polarization within the quantum well. Profile of energy band
and distributions of electrons and holes demonstrate the existence of a main
active site in the well responsible for the main band-edge light emission. This
site appears at the position where the local polarization becomes zero. With
charge injection, the calculated optical spectra show that the broadening of
the band gap at the active site leads to the blueshift of emission wavelength
Testing the Lorentz and CPT Symmetry with CMB polarizations and a non-relativistic Maxwell Theory
We present a model for a system involving a photon gauge field and a scalar
field at quantum criticality in the frame of a Lifthitz-type non-relativistic
Maxwell theory. We will show this model gives rise to Lorentz and CPT violation
which leads to a frequency-dependent rotation of polarization plane of
radiations, and so leaves potential signals on the cosmic microwave background
temperature and polarization anisotropies.Comment: 7 pages, 2 figures, accepted on JCAP, a few references adde
Cyclic cosmology from Lagrange-multiplier modified gravity
We investigate cyclic and singularity-free evolutions in a universe governed
by Lagrange-multiplier modified gravity, either in scalar-field cosmology, as
well as in one. In the scalar case, cyclicity can be induced by a
suitably reconstructed simple potential, and the matter content of the universe
can be successfully incorporated. In the case of -gravity, cyclicity can
be induced by a suitable reconstructed second function of a very
simple form, however the matter evolution cannot be analytically handled.
Furthermore, we study the evolution of cosmological perturbations for the two
scenarios. For the scalar case the system possesses no wavelike modes due to a
dust-like sound speed, while for the case there exist an oscillation
mode of perturbations which indicates a dynamical degree of freedom. Both
scenarios allow for stable parameter spaces of cosmological perturbations
through the bouncing point.Comment: 8 pages, 3 figures, references added, accepted for publicatio
Numerical simulation of solid tumor blood perfusion and drug delivery during the “vascular normalization window” with antiangiogenic therapy
This Article is provided by the Brunel Open Access Publishing Fund - Copyright @ 2011 Hindawi PublishingTo investigate the influence of vascular normalization on solid tumor blood perfusion and drug delivery, we used the generated blood vessel network for simulations. Considering the hemodynamic parameters changing after antiangiogenic therapies, the results show that the interstitial fluid pressure (IFP) in tumor tissue domain decreases while the pressure gradient increases during the normalization window. The decreased IFP results in more efficient delivery of conventional drugs to the targeted cancer cells. The outcome of therapies will improve if the antiangiogenic therapies and conventional therapies are carefully scheduled
FPTAS for Weighted Fibonacci Gates and Its Applications
Fibonacci gate problems have severed as computation primitives to solve other
problems by holographic algorithm and play an important role in the dichotomy
of exact counting for Holant and CSP frameworks. We generalize them to weighted
cases and allow each vertex function to have different parameters, which is a
much boarder family and #P-hard for exactly counting. We design a fully
polynomial-time approximation scheme (FPTAS) for this generalization by
correlation decay technique. This is the first deterministic FPTAS for
approximate counting in the general Holant framework without a degree bound. We
also formally introduce holographic reduction in the study of approximate
counting and these weighted Fibonacci gate problems serve as computation
primitives for approximate counting. Under holographic reduction, we obtain
FPTAS for other Holant problems and spin problems. One important application is
developing an FPTAS for a large range of ferromagnetic two-state spin systems.
This is the first deterministic FPTAS in the ferromagnetic range for two-state
spin systems without a degree bound. Besides these algorithms, we also develop
several new tools and techniques to establish the correlation decay property,
which are applicable in other problems
Bounce and cyclic cosmology in extended nonlinear massive gravity
We investigate non-singular bounce and cyclic cosmological evolutions in a
universe governed by the extended nonlinear massive gravity, in which the
graviton mass is promoted to a scalar-field potential. The extra freedom of the
theory can lead to certain energy conditions violations and drive cyclicity
with two different mechanisms: either with a suitably chosen scalar-field
potential under a given Stuckelberg-scalar function, or with a suitably chosen
Stuckelberg-scalar function under a given scalar-field potential. Our analysis
shows that extended nonlinear massive gravity can alter significantly the
evolution of the universe at both early and late times.Comment: 20 pages, 5 figures, version published at JCA
Heterodimerization of apelin receptor and neurotensin receptor 1 induces phosphorylation of ERK1/2 and cell proliferation via Gαq-mediated mechanism
Dimerization of G protein-coupled receptors (GPCRs) is crucial for receptor function including agonist affinity, efficacy, trafficking and specificity of signal transduction, including G protein coupling. Emerging data suggest that the cardiovascular system is the main target of apelin, which exerts an overall neuroprotective role, and is a positive regulator of angiotensin-converting enzyme 2 (ACE2) in heart failure. Moreover, ACE2 cleaves off C-terminal residues of vasoactive peptides including apelin-13, and neurotensin that activate the apelin receptor (APJ) and neurotensin receptor 1 (NTSR1) respectively, that belong to the A class of GPCRs. Therefore, based on the similar mode of modification by ACE2 at peptide level, the homology at amino acid level and the capability of forming dimers with other GPCRs, we have been suggested that APJ and NTSR1 can form a functional heterodimer. Using co-immunoprecipitation, BRET and FRET, we provided conclusive evidence of heterodimerization between APJ and NTSR1 in a constitutive and induced form. Upon agonist stimulation, hetrodimerization enhanced ERK1/2 activation and increased proliferation via activation of Gq α-subunits. These novel data provide evidence for a physiological role of APJ/NTSR1 heterodimers in terms of ERK1/2 activation and increased intracellular calcium and induced cell proliferation and provide potential new pharmaceutical targets for cardiovascular disease. © 2014 The Authors
A Tight Karp-Lipton Collapse Result in Bounded Arithmetic
Cook and Krajíček [9] have obtained the following Karp-Lipton result in bounded arithmetic: if the theory proves , then collapses to , and this collapse is provable in . Here we show the converse implication, thus answering an open question from [9]. We obtain this result by formalizing in a hard/easy argument of Buhrman, Chang, and Fortnow [3]. In addition, we continue the investigation of propositional proof systems using advice, initiated by Cook and Krajíček [9]. In particular, we obtain several optimal and even p-optimal proof systems using advice. We further show that these p-optimal systems are equivalent to natural extensions of Frege systems
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