Microscopic origin of light emission in Al_yGa_{1-y}N/GaN superlattice: Band profile and active site

We present first-principles calculations of AlGaN/GaN superlattice, clarifying the microscopic origin of the light emission and revealing the effect of local polarization within the quantum well. Profile of energy band and distributions of electrons and holes demonstrate the existence of a main active site in the well responsible for the main band-edge light emission. This site appears at the position where the local polarization becomes zero. With charge injection, the calculated optical spectra show that the broadening of the band gap at the active site leads to the blueshift of emission wavelength

Testing the Lorentz and CPT Symmetry with CMB polarizations and a non-relativistic Maxwell Theory

We present a model for a system involving a photon gauge field and a scalar field at quantum criticality in the frame of a Lifthitz-type non-relativistic Maxwell theory. We will show this model gives rise to Lorentz and CPT violation which leads to a frequency-dependent rotation of polarization plane of radiations, and so leaves potential signals on the cosmic microwave background temperature and polarization anisotropies.Comment: 7 pages, 2 figures, accepted on JCAP, a few references adde

Cyclic cosmology from Lagrange-multiplier modified gravity

We investigate cyclic and singularity-free evolutions in a universe governed by Lagrange-multiplier modified gravity, either in scalar-field cosmology, as well as in $f(R)$ one. In the scalar case, cyclicity can be induced by a suitably reconstructed simple potential, and the matter content of the universe can be successfully incorporated. In the case of $f(R)$-gravity, cyclicity can be induced by a suitable reconstructed second function $f_2(R)$ of a very simple form, however the matter evolution cannot be analytically handled. Furthermore, we study the evolution of cosmological perturbations for the two scenarios. For the scalar case the system possesses no wavelike modes due to a dust-like sound speed, while for the $f(R)$ case there exist an oscillation mode of perturbations which indicates a dynamical degree of freedom. Both scenarios allow for stable parameter spaces of cosmological perturbations through the bouncing point.Comment: 8 pages, 3 figures, references added, accepted for publicatio

Numerical simulation of solid tumor blood perfusion and drug delivery during the “vascular normalization window” with antiangiogenic therapy

This Article is provided by the Brunel Open Access Publishing Fund - Copyright @ 2011 Hindawi PublishingTo investigate the influence of vascular normalization on solid tumor blood perfusion and drug delivery, we used the generated blood vessel network for simulations. Considering the hemodynamic parameters changing after antiangiogenic therapies, the results show that the interstitial fluid pressure (IFP) in tumor tissue domain decreases while the pressure gradient increases during the normalization window. The decreased IFP results in more efficient delivery of conventional drugs to the targeted cancer cells. The outcome of therapies will improve if the antiangiogenic therapies and conventional therapies are carefully scheduled

FPTAS for Weighted Fibonacci Gates and Its Applications

Fibonacci gate problems have severed as computation primitives to solve other problems by holographic algorithm and play an important role in the dichotomy of exact counting for Holant and CSP frameworks. We generalize them to weighted cases and allow each vertex function to have different parameters, which is a much boarder family and #P-hard for exactly counting. We design a fully polynomial-time approximation scheme (FPTAS) for this generalization by correlation decay technique. This is the first deterministic FPTAS for approximate counting in the general Holant framework without a degree bound. We also formally introduce holographic reduction in the study of approximate counting and these weighted Fibonacci gate problems serve as computation primitives for approximate counting. Under holographic reduction, we obtain FPTAS for other Holant problems and spin problems. One important application is developing an FPTAS for a large range of ferromagnetic two-state spin systems. This is the first deterministic FPTAS in the ferromagnetic range for two-state spin systems without a degree bound. Besides these algorithms, we also develop several new tools and techniques to establish the correlation decay property, which are applicable in other problems

Bounce and cyclic cosmology in extended nonlinear massive gravity

We investigate non-singular bounce and cyclic cosmological evolutions in a universe governed by the extended nonlinear massive gravity, in which the graviton mass is promoted to a scalar-field potential. The extra freedom of the theory can lead to certain energy conditions violations and drive cyclicity with two different mechanisms: either with a suitably chosen scalar-field potential under a given Stuckelberg-scalar function, or with a suitably chosen Stuckelberg-scalar function under a given scalar-field potential. Our analysis shows that extended nonlinear massive gravity can alter significantly the evolution of the universe at both early and late times.Comment: 20 pages, 5 figures, version published at JCA

Heterodimerization of apelin receptor and neurotensin receptor 1 induces phosphorylation of ERK1/2 and cell proliferation via Gαq-mediated mechanism

Dimerization of G protein-coupled receptors (GPCRs) is crucial for receptor function including agonist affinity, efficacy, trafficking and specificity of signal transduction, including G protein coupling. Emerging data suggest that the cardiovascular system is the main target of apelin, which exerts an overall neuroprotective role, and is a positive regulator of angiotensin-converting enzyme 2 (ACE2) in heart failure. Moreover, ACE2 cleaves off C-terminal residues of vasoactive peptides including apelin-13, and neurotensin that activate the apelin receptor (APJ) and neurotensin receptor 1 (NTSR1) respectively, that belong to the A class of GPCRs. Therefore, based on the similar mode of modification by ACE2 at peptide level, the homology at amino acid level and the capability of forming dimers with other GPCRs, we have been suggested that APJ and NTSR1 can form a functional heterodimer. Using co-immunoprecipitation, BRET and FRET, we provided conclusive evidence of heterodimerization between APJ and NTSR1 in a constitutive and induced form. Upon agonist stimulation, hetrodimerization enhanced ERK1/2 activation and increased proliferation via activation of Gq α-subunits. These novel data provide evidence for a physiological role of APJ/NTSR1 heterodimers in terms of ERK1/2 activation and increased intracellular calcium and induced cell proliferation and provide potential new pharmaceutical targets for cardiovascular disease. © 2014 The Authors

A Tight Karp-Lipton Collapse Result in Bounded Arithmetic

Cook and Krajíček [9] have obtained the following Karp-Lipton result in bounded arithmetic: if the theory proves , then collapses to , and this collapse is provable in . Here we show the converse implication, thus answering an open question from [9]. We obtain this result by formalizing in a hard/easy argument of Buhrman, Chang, and Fortnow [3]. In addition, we continue the investigation of propositional proof systems using advice, initiated by Cook and Krajíček [9]. In particular, we obtain several optimal and even p-optimal proof systems using advice. We further show that these p-optimal systems are equivalent to natural extensions of Frege systems