Freezing and melting line invariants of the Lennard-Jones system

The invariance of several structural and dynamical properties of the Lennard-Jones (LJ) system along the freezing and melting lines is interpreted in terms of the isomorph theory. First the freezing/melting lines for LJ system are shown to be approximated by isomorphs. Then we show that the invariants observed along the freezing and melting isomorphs are also observed on other isomorphs in the liquid and crystalline phase. Structure is probed by the radial distribution function and the structure factor and dynamics is probed by the mean-square displacement, the intermediate scattering function, and the shear viscosity. Studying these properties by reference to the isomorph theory explains why known single-phase melting criteria holds, e.g., the Hansen-Verlet and the Lindemann criterion, and why the Andrade equation for the viscosity at freezing applies, e.g., for most liquid metals. Our conclusion is that these empirical rules and invariants can all be understood from the isomorph theory and that the invariants are not peculiar to the freezing and melting lines, but hold along all isomorphs.Comment: 21 pg, 12 figures Accepted from PCCP (Physical Chemistry Chemical Physics

Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors

Background Suicide is a leading cause of death worldwide, and nonfatal suicide attempts, which occur far more frequently, are a major source of disability and social and economic burden. Both have substantial genetic etiology, which is partially shared and partially distinct from that of related psychiatric disorders. Methods We conducted a genome-wide association study (GWAS) of 29,782 suicide attempt (SA) cases and 519,961 controls in the International Suicide Genetics Consortium (ISGC). The GWAS of SA was conditioned on psychiatric disorders using GWAS summary statistics via multitrait-based conditional and joint analysis, to remove genetic effects on SA mediated by psychiatric disorders. We investigated the shared and divergent genetic architectures of SA, psychiatric disorders, and other known risk factors. Results Two loci reached genome-wide significance for SA: the major histocompatibility complex and an intergenic locus on chromosome 7, the latter of which remained associated with SA after conditioning on psychiatric disorders and replicated in an independent cohort from the Million Veteran Program. This locus has been implicated in risk-taking behavior, smoking, and insomnia. SA showed strong genetic correlation with psychiatric disorders, particularly major depression, and also with smoking, pain, risk-taking behavior, sleep disturbances, lower educational attainment, reproductive traits, lower socioeconomic status, and poorer general health. After conditioning on psychiatric disorders, the genetic correlations between SA and psychiatric disorders decreased, whereas those with nonpsychiatric traits remained largely unchanged. Conclusions Our results identify a risk locus that contributes more strongly to SA than other phenotypes and suggest a shared underlying biology between SA and known risk factors that is not mediated by psychiatric disorders.Peer reviewe

Evidence-based models and interventions in primary care

This chapter focuses on the rationale, development, and applications of evidence-based models and interventions in the primary care setting. (PsycINFO Database Record (c) 2012 APA, all rights reserved). (chapter

Detection of Anorexia Nervosa in Primary Care: Effects of Patient Ethnicity, History of Mental Illness, Physician Gender, and Years of Experience.

Poster presentation accepted for the 47th Annual Association for the Advancement of Behavioral and Cognitive Therapies, Philadelphia, PA

Primary care psychology

This chapter discusses the discipline of primary care psychology. Within the past several years, the interface between professional psychology and primary care medicine has begun to burgeon. Primary care psychology may be defined as the provision of health and mental health services that includes the prevention of disease and the promotion of healthy behaviors in individuals, families, and communities . This specialty area has recently become a major focus of interest and study and has challenged psychologists to rethink their roles, functions, and modalities of professional practice. Today, the emergence of primary care psychology as a model for integrating psychology and medicine is at the forefront of the health-care reform movement. This new movement has been driven by a variety of forces rooted deeply in the interest to deliver health care in a most efficient and effective manner. Among other things, what uniquely defines this area are the problems presented in the primary care setting and the important role that psychological factors play in health and wellness. In consideration of these factors, the meshing of professional psychology and primary care medicine is not only welcome but has been a long time coming. In describing primary care, DiTomasso and Esposito note the following: Physicians have begun to realize that a thorough understanding and treatment of the whole patient is critical in accurately conceptualizing patient problems and in developing effective interventions. Primary care patients present with a multitude of possible problems, many of which have central components that are behavioral in nature. Given the reciprocal and synergistic relationship that exists between mind and body phenomenon, there is little wonder why patients seeking care from primary care physicians (PCPs) may do so for a variety of mental and physical reasons. The convergence of a number of historical factors has evolved to shape the emergence of primary care psychology as a critical specialty area. (PsycINFO Database Record (c) 2013 APA, all rights reserved). (chapter

Specialty competencies in clinical psychology

This series presents methods, strategies, and techniques for conducting day-to-day practice in any clinical psychology. This volume addresses best practices across the functional and foundational competencies that characterize clinical psychology. Functional competencies include common practice activities like assessment and intervention, while foundational competencies represent core knowledge areas such as ethical and legal issues, cultural diversity, and professional identification. In addition to describing these competencies, this book provides a definition, description, and development timeline of clinical psychology, including its essential and characteristic pattern of activities, as well as its distinctive and unique features. (PsycINFO Database Record (c) 2014 APA, all rights reserved). (create