Four Years of Extreme Ultraviolet Observations of Markarian 421: II. Temporal Analysis

The Extreme Ultraviolet Explorer (EUVE) satellite accumulated ~one million seconds of public data between 1994 and 1997 for the BL Lacertae object Markarian 421. This is the second of two papers in which we present the results of spectral and temporal analysis of this EUVE data set. We analyze in the present paper the imaging data by means of power spectrum and structure function techniques, while the spectral analysis is presented in a companion paper. We find for MRK 421 a power spectrum with slope -2.14 +- 0.28 with a break at ~3 days. This is the first time that a break in the power spectrum of a BL Lacertae object has been found. We also find evidence of non-stationarity for MRK 421 EUV emissionComment: Accepted for publication in the Astrophysical Journal. 16 pages, 14 Postscript figures, 3 Table

Prediction of hearing recovery in sudden deafness treated with intratympanic steroids

The present study aims to obtain a probability model allowing the prediction of the auditory recovery in patients affected by sudden sensorineural hearing loss treated exclusively with intratympanic steroids. A monocentric retrospective chart review of three-hundred eighty-one patients has been performed. A Probit model was used to investigate the correlation between the success of the treatment (marked or total recovery according to Furuashi's criteria), and the delay between the onset of disease and the beginning of therapy. The age of the patients and the audiometric curve shapes were included in the analysis. Results show that delay is negatively correlated with the variable success. Considering the entire sample, each day of delay decreases by 3% the probability of success. The prediction model shows that for every day that passes from the onset of the disease the probability of success declines in absence of the medical treatment, hence we conclude that early treatment is strongly recommended

Emotion-based analysis of programming languages on Stack Overflow

When developing a software engineering project, selecting the most appropriate programming language is a crucial step. Most often, feeling at ease with the possible options becomes almost as relevant as the technical features of the language. Therefore, it appears to be worth analyzing the role that the emotional component plays in this process. In this article, we analyze the trend of the emotions expressed by developers in 2018 on the Stack Overflow platform in posts concerning 26 programming languages. To do so, we propose a learning model trained by distant supervision and the comparison of two different classifier architectures

The BeppoSAX view of the hard X-ray background

First results on a medium-deep X-ray survey in the "new" 5-10 keV band carried out with the MECS detectors onboard BeppoSAX are presented. The High Energy Llarge Area Survey (HELLAS) is aimed to directly explore a band where the energy density of the X-ray background is more than twice than that in the soft (0.5-2.0 keV) band. The optical identification follow-up of the first ten HELLAS hard X-ray sources indicate that Active Galactic Nuclei are the dominant population at 5-10 keV fluxes of the order of 10e-13 cgs. We discuss the implications of these findings for the AGN synthesis models for the XRB.Comment: 6 pages, 4 figures, uses psfig.sty. Accepted for publication in Advances in Space Research, Proceedings of the 32nd Scientific Assembly of COSPA

A Medium Survey of the Hard X-Ray Sky with ASCA. II.: The Source's Broad Band X-Ray Spectral Properties

A complete sample of 60 serendipitous hard X-ray sources with flux in the range $\sim 1 \times 10^{-13}$ \ecs to $\sim 4 \times 10^{-12}$ \ecs (2 - 10 keV), detected in 87 ASCA GIS2 images, was recently presented in literature. Using this sample it was possible to extend the description of the 2-10 keV LogN(>S)-LogS down to a flux limit of $\sim 6\times 10^{-14}$ \ecs (the faintest detectable flux), resolving about a quarter of the Cosmic X-ray Background. In this paper we have combined the ASCA GIS2 and GIS3 data of these sources to investigate their X-ray spectral properties using the "hardness" ratios and the "stacked" spectra method. Because of the sample statistical representativeness, the results presented here, that refer to the faintest hard X-ray sources that can be studied with the current instrumentation, are relevant to the understanding of the CXB and of the AGN unification scheme.Comment: 28 pages plus 6 figures, LaTex manuscript, Accepted for publication in the Astrophysical Journal, Figure 5 can retrieved via anonymous ftp at ftp://ftp.brera.mi.astro.it/pub/ASCA/paper2/fig5.ps.g

Reduced number and function of peripheral dendritic cells in coeliac disease.

Dendritic cells (DC) play a pivotal role in shaping the immune response in both physiological and pathological conditions. In peripheral blood at least two subsets, the myeloid and plasmacytoid, have been described as having different T stimulatory functions and a variable degree of maturation. Certainly, antigen presentation plays a crucial role in the pathogenesis of coeliac disease and circulating immune cells are thought to reflect the state of immune response within the gut. Therefore,we aimed to investigate the quantitative and phenotypical modifications of peripheral bloodDC, together with their functional properties, in this pathological condition. Blood samples from 11 untreated patients before and after a course of gluten-free diet, 27 treated patients and 14 controls underwent flow-cytometric analysis, while immunomagnetically sorted DC from the CD patients and eight human leucocyte antigen (HLA)-DQ2/8+ bone marrow donors were used to evaluate maturation status through the CD83 expression, cytokine profile for interleukin (IL)-6, IL-10, IL-12 and interferon (IFN)-a by enzyme-linked immunosorbent assay (ELISA), and functional properties by mixed leucocyte reaction before and after pulsing with digested gliadin. We found that in both untreated and treated patients, a significant reduction of the entire DC population, mainly the plasmacytoid subset, in comparison to healthy controls was observed. In active disease, an impaired allogenic lymphocyte reaction and a significant reduction of IFN-a production, paralleled by the presence of a more immature status, were also demonstrated. All the latter modifications have been reverted by pulsing DC with digested gliadin

Testing current synthesis models of the X-ray background

We present synthesis models of the X-ray background where the available X-ray observational constraints are used to derive information on the AGN population properties. We show the need for luminous X-ray absorbed AGNs, the QSO2s, in reproducing the 2-10 keV source counts at relatively bright fluxes. We compare a model where the evolution of absorbed AGNs is faster than that of unabsorbed ones, with a standard model where absorbed and unabsorbed AGNs evolve at the same rate. It is found that an increase by a factor of ~2 from z=0 to z~1.3 in the ratio between absorbed and unabsorbed AGNs would provide a significant improvement in the data description. Finally, we make predictions on the AGNs to be observed in deep X-ray surveys which contain information on the AGN space density at high redshift.Comment: 11 pages with 8 figures, A&A accepte

Resolving the extragalactic hard X-ray background

The origin of the hard (2-10 keV) X-ray background has remained mysterious for over 35 years. Most of the soft (0.5-2 keV) X-ray background has been resolved into discrete sources, which are primarily quasars; however, these sources do not have the flat spectral shape required to match the X-ray background spectrum. Here we report the results of an X-ray survey 30 times more sensitive than previous studies in the hard band and four times more sensitive in the soft band. The sources detected in our survey account for at least 75 per cent of the hard X-ray background. The mean X-ray spectrum of these sources is in good agreement with that of the background. The X-ray emission from the majority of the detected sources is unambiguously associated with either the nuclei of otherwise normal bright galaxies or optically faint sources, which could either be active nuclei of dust enshrouded galaxies or the first quasars at very high redshifts.Comment: Nature article in pres