Implications of a nuclear Iran for Turkey

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Probiotic Lactobacillus paracasei effect on cariogenic bacterial flora

Lactobacillus paracasei has been demonstrated to inhibit the growth of many pathogenic microbes such as Streptococcus mutans, in vitro. However, its clinical application remains unclear. Here, we examined whether a novel probiotic L. paracasei GMNL-33 may reduce the caries-associated salivary microbial counts in healthy adults. Seventy-eight subjects (aged 20 to 26) had completed this double-blinded, randomized, placebo-controlled study. A probiotic/test (n = 42) and a control group (n = 36) took a L. paracasei GMNL-33 and a placebo oral tablet three times per day for 2 weeks, respectively. Bacterial counts of salivary S. mutans, lactobacilli, and salivary buffer capacity were measured with chair-side kits at the beginning (T1), the completion (T2) of medication, and 2 weeks after medication (T3). The results did not show differences in the counts of S. mutans and lactobacilli between probiotic and control groups at T1, T2, and T3. Nevertheless, within the probiotic group, an interesting probiotic effect was noticed. Between T1 and T2, no inhibitory effect against S. mutans was observed. However, a significant count reduction in the salivary S. mutans was detected between T2 and T3 (p = 0.016). Thus, a 2-week period of medication via oral administration route may be needed for L. paracasei GMNL-33 to be effective in the probiotic action

Local site effects in Ataköy, Istanbul, Turkey, due to a future large earthquake in the Marmara Sea

Since the 1999 Izmit and Düzce earthquakes in northwest Turkey, many seismic hazard studies have focused on the city of Istanbul. An important issue in this respect is local site effects: strong amplifications are expected at a number of locations due to the local geological conditions. In this study we estimate the local site effects in the Ataköy area (southwestern Istanbul) by applying several techniques using synthetic data (hybrid 3-D modelling and 1-D modelling) and comparing to empirical data. We apply a hybrid 3-D finite-difference method that combines a complex source and wave propagation for a regional 1-D velocity model with site effects calculated for a local 3-D velocity structure. The local velocity model is built from geological, geotechnical and geomorphological data. The results indicate that strongest spectral amplifications (SA) in the Ataköy area occur around 1 Hz and that amplification levels are largest for alluvial sites where SA reaching a factor of 1.5-2 can be expected in the case of a large earthquake. We also compare our results to H/V (horizontal to vertical component of the recorded signal) spectral ratios calculated for microtremor data recorded at 30 sites as well as to ambient noise synthetics simulated using a 1-D approach. Because the applied methods complement each other, they provide comprehensive and reliable information about the local site effects in Ataköy. Added to that, our results have significant implications for the southwestern parts of Istanbul built on similar geological formations, for which, therefore, similar SA levels are expecte

Tailoring swelling to control softening mechanisms during cyclic loading of PEG/cellulose hydrogel composites

One of the novel approaches for discogenic lower back pain treatment is to permanently replace the core of the intervertebral disc, so-called Nucleus Pulposus, through minimally invasive surgery. Recently, we have proposed Poly(Ethylene Glycol) Dimethacrylate (PEGDM) hydrogel reinforced with Nano-Fibrillated Cellulose (NFC) fibers as an appropriate replacement material. In addition to the tuneable properties, that mimic those of the native tissue, the surgeon can directly inject it into the degenerated disc and cure it in situ via UV-light irradiation. However, in view of clinical applications, the reliability of the proposed material has to be tested under long-term fatigue loading. To that end, the present study focused on the characterization of the fatigue behavior of the composite hydrogel and investigated the governing physical phenomena behind it. The results show that composite PEGDM-NFC hydrogel withstands the 10 million compression cycles at physiological condition. However, its modulus decreases by almost 10% in the first cycle and then remains constant, while cyclic loading does not affect the neat PEGDM hydrogel. The observed softening behavior has similar characteristics of the Mullins effect. It is shown that the reduction of modulus is due to the gradual change of NFC network, which is highly stretched in the swollen state. Moreover, the swelling degree of the matrix is correlated to the extent of softening during cyclic loading. Consequently, softening can be minimized by lowering the swelling of the composite hydrogel

Heterogeneous Delays in Neural Networks

We investigate heterogeneous coupling delays in complex networks of excitable elements described by the FitzHugh-Nagumo model. The effects of discrete as well as of uni- and bimodal continuous distributions are studied with a focus on different topologies, i.e., regular, small-world, and random networks. In the case of two discrete delay times resonance effects play a major role: Depending on the ratio of the delay times, various characteristic spiking scenarios, such as coherent or asynchronous spiking, arise. For continuous delay distributions different dynamical patterns emerge depending on the width of the distribution. For small distribution widths, we find highly synchronized spiking, while for intermediate widths only spiking with low degree of synchrony persists, which is associated with traveling disruptions, partial amplitude death, or subnetwork synchronization, depending sensitively on the network topology. If the inhomogeneity of the coupling delays becomes too large, global amplitude death is induced

Electrical and optical characterization of Os-substituted rare-earth orthoferrite YbFeO3-gamma powders

The electrical properties of Os-doped YbFeO3 (YbFO) powders prepared by solid-state reaction have been studied by Impedance Spectrometer/Impedance Spectrometer. SEM, XPS and Raman spectroscopy were utilized for understanding chemical and structured analysis of the synthesized compounds. SEM images have revealed the void nature of the pellets. Furthermore, XPS studies have exhibited that Yb has 3+valance state. It is also revealed that the oxygen vacancies concentration drops as the Os doping level raises by XPS analysis. The frequency dependency of loss-tan(delta) examination has demonstrated that the 5 mol% Os-substituted sample has the lowest loss-tan(delta) values at high frequency regions at 100 degrees C. It has been also realized that the 5 mol% Os-doped compound exhibits the highest resistivity among the samples. Raman spectroscopy examination has unveiled that the samples have similar space group. In addition, the optical band gap of the synthesized powders was also extracted via utilizing the Kubelka-Munk technique. It was realized that the band gap of YbFO slightly increases as the Os dopant ratio advances