Removal of the broken part of implantable cardioverter-defibrillator's electrode causing pulmonary embolism via femoral vein

AbstractA 66-year-old patient with idiopathic dilated cardiomyopathy underwent transvenous extraction of an implantable cardioverter-defibrillator. The distal part of the electrode was broken during manual traction through the left subclavian vein. In the present case, we showed a rare complication of transvenous lead extraction and its management

S100A1 as a Potential Diagnostic Biomarker for Assessing Cardiotoxicity and Implications for the Chemotherapy of Certain Cancers.

This study examined the value of blood marker S100A1 in detecting cardiotoxicity induced by chemotherapy agents; trastuzumab and lapatinib, in normal rat heart. The rats were divided into three groups: control (n = 8, no treatment), T (n = 8, one time ip treatment with 10 mg/kg trastuzumab) and L (n = 8, oral treatment with 100 mg/kg/day lapatinib for 7 days). The activities of oxidative stress parameters Malondialdehyde (MDA), Superoxide dismutase (SOD), Catalase (CAT) and Glutathione (GSH) were measured from the extracted cardiac tissues. The levels of troponinI and S100A1 expressions were measured from blood samples. All biomarkers responded to the treatments as they exhibited alterations from their normative values, validating the chemically induced cardiotoxicity. S100A1 expression attenuated significantly (75%), which made the sensitive detection of cardiotoxicity feasible. Assessment of cardiotoxicity with S100A1 may be a valuable alternative in clinical oncology of cancers in some organs such as breast and prostate, as they do not overexpress it to compete against

Levels of cardiac injury parameters as measured from the bloods collected from all experimental groups (each with n = 8).

<p>Panels show graphs for the markers TroponinI and S100A1. Multi group Kruskal Wallis test yielded <i>P</i> = 0.0280 and 0.0354, respectively. * indicates statistically significant difference against the control group C (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0145418#pone.0145418.t001" target="_blank">Table 1</a>).</p

Oxidative stress parameters as measured from the cardiac tissues extracted from the animals in all experimental groups (each with n = 8).

<p>Panels show graphs for the biochemical markers Malonyldialdehyde (MDA); Superoxide dismutase (SOD); Catalase (CAT); Glutathione (GSH). Multi group Kruskal Wallis test yielded <i>P</i> = 0.0003, 0.0003, 0.0002 and 0.0005, respectively. * indicates statistically significant difference against the control group C (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0145418#pone.0145418.t001" target="_blank">Table 1</a>).</p