52 research outputs found

    Determination of the geometry of the PSR B1913+16 system by geodetic precession

    Get PDF
    New observations of the binary pulsar B1913+16 are presented. Since 1978 the leading component of the pulse profile has weakend dramatically by about 40%. For the first time, a decrease in component separation is observed, consistent with expectations of geodetic precession. Assuming the correctness of general relativity and a circular hollow-cone like beam, a fully consistent model for the system geometry is developed. The misalignment angle between pulsar spin and orbital momentum is determined giving direct evidence for an asymmetric kick during the second supernova explosion. It is argued that the orbital inclination angle is 132\fdg8 (rather than 47\fdg2). A prediction of this model is that PSR B1913+16 will not be observable anymore after the year 2025.Comment: 16 pages, incl. 5 figures, accepted for publication in Ap

    Melting, Solidification, and Crystallization of a Thermoplastic Polyurethane as a Function of Hard Segment Content

    Get PDF
    Thermoplastic polyurethanes (TPU) with varying hard segment contents (HSC) are monitored during melting and solidifying (20 K/min , Tmax = 220 ° C) by small-angle and wide-angle X-ray scattering (WAXS and SAXS). Hard segments: MDI/BD. Soft segments: PTHF1000. The neat materials are injection-molded, having small amorphous hard domains (chord length d⎯⎯h ∼ 35% show sharp Bragg peaks and larger hard domains ( d⎯⎯h > 7 nm ). When heated, small domains melt, but crystallization in the remaining large domains is not detected. Upon cooling, large agglomerates segregate first, which crystallize immediately. Segregation starts for HSC = 42% at 160 °C and for HSC = 75% at 210 °C. When HSC ≤ 30%, the morphologies before and after are similar, but afterward, many hard blocks are dissolved in the soft phase at the expense of the hard domain fraction. In heating and cooling the melts, multiple homogenization and segregation processes are observed, which are explained by the agglomeration of hard blocks of different lengths in the colloidal fluid

    Two open states and rate-limiting gating steps revealed by intracellular Na+ block of human KCNQ1 and KCNQ1/KCNE1 K+ channels

    No full text
    KCNQ1, the first member of a new K+ channel family, associates with the small KCNE1 subunit to form the slow cardiac delayed rectifier current, IKs. Mutations in both genes encoding these channels lead to cardiac arrhythmia. We studied the block by intracellular Na+ of human homomeric KCNQ1 (homomers) and heteromeric KCNQ1/KCNE1 (heteromers) expressed in CHO cells (Chinese hamster ovary cell line) using whole-cell patch recording.In the nominal absence of extracellular K+ and with 65 mm intracellular K+, the replacement of 65 mm intracellular N-methyl-d-glucamine (NMDG+) by 65 mm Na+ induced a decay of outward (K+) currents through homomers after maximal activation reminiscent of an inactivation process. The decay had a time constant in the hundreds of milliseconds range.The inactivation process of homomers was, however, not directly dependent on [Na+]i, as evidenced by unaltered biphasic deactivation at negative voltages.An instantaneous voltage-dependent Na+ block of homomers was revealed using tail current protocols with activating prepulses that saturated the gating processes of the channel. The instantaneous block was partially relieved at very large positive voltages (≥ 60 mV) and in 20 mm extracellular K+. The instantaneous block of homomers was much less pronounced if the tail currents were measured after short activating prepulses, demonstrating the presence of (at least) two open states: a first, relatively [Na+]i-insensitive and a subsequent [Na+]i-sensitive open state; the current decay reflects the transition between the two open states.Heteromers exhibited a very similar instantaneous block by Nai+ independently of the prepulse duration. Heteromers did not show a Nai+-induced current decay.Our results demonstrate the presence of two open states of KCNQ1 channels with different [Na+]i sensitivities. The rate-limiting step of homomeric KCNQ1 gating at positive voltages is the transition between these two open states. The rate-limiting step of the gating of KCNQ1/KCNE1 channels appears to be the entry into the first open state
    • …
    corecore