Falla por flujo de bauxita saturada sometidas a cargas monotónicas no drenadas

Identifica la susceptibilidad a falla por flujo de licuación en pilas de bauxita transportadas de manera marítima. La falla por flujo es un fenómeno con consecuencias catastróficas del fenómeno de licuación de suelos que ocurre también en materiales mineros. Este trabajo de maestría busca determinar el grado de susceptibilidad del ore de bauxita a falla por flojo durante el transporte marítimo debido a cargas cíclicas utilizando ensayos triaxiales no drenados y la teoría del estado crítico.The main objective of this thesis is to study the undrained monotonic behavior at large deformations of Bauxite under several conditions of density and effective confining stress. The specific objectives are: 1) To verify the applicability of the Steady State theory to this type of soil; 2) To estimate undrained residual shear strength for the post-seismic stability analysis of bauxite heaps; y 3) To compare the behavior of Bauxite with a mix of Silica Sands of similar particle size distribution.Japón. Ministerio de Educación, Ciencia, Cultura, Deporte y Tecnología : Beca MEXTTesi

Clinical evolution of hypertension and proteinuria in patients who developed preeclampsia.

This a report of the clinical follow-up of women affected by preeclampsia.Introduction: Preeclampsia-eclampsia has been one of the main cause of maternal morbidity-mortality in developing countries, affecting 10% of pregnancies. In Mexico, in the recent years it has been estimated at about 2 to 35 new cases per 100 pregnancies. Objective: To report the evolution and severity of blood pressure and proteinuria; and their repercussion on renal function after delivery, in patients who developed preeclampsia. Methods: It was a descriptive analysis of 24 preeclamptic women on clinical follow up until normalization of blood pressure. Results: We observed lower serum albumin, higher severity of 24 hrs proteinuria level and longer duration of hypertension in those women who presented with the highest levels in diastolic blood pressure at the beginning and end of the study

Herramientas didácticas para la formación agroforestal

Como resultado de los trabajos de investigación por más de diez años del grupo Plan de Investigación para el Fortalecimiento Integral de las Comunidades – PIFIL, en este libro se evidencias las lecciones aprendidas en el diseño y uso de herramientas didácticas para la formación de comunidades rurales, destacándose el material didáctico manual y digital agroforestal como innovadores en la implementación de las tecnologías de la información y la comunicación – TIC que facilitan los procesos de enseñanza aprendizaje para la aprehensión del conocimiento, consolidación del tejido social; fortalecimiento de la cohesión y congestión que coadyuvan con el mejoramiento de los medios de vida y uso sustentable de los recursos naturales

An industrial scale process for the enzymatic removal of steryl glucosides from biodiesel

Background: Biodiesels produced from transesterification of vegetable oils have a major quality problem due to thepresence of precipitates, which need to be removed to avoid clogging of filters and engine failures. These precipitateshave been reported to be mostly composed of steryl glucosides (SGs), but so far industrial cost-effective methods toremove these compounds are not available. Here we describe a novel method for the efficient removal of SGs frombiodiesel, based on the hydrolytic activity of a thermostable β-glycosidase obtained from Thermococcus litoralis.Results: A steryl glucosidase (SGase) enzyme from T. litoralis was produced and purified from Escherichia coli culturesexpressing a synthetic gene, and used to treat soybean-derived biodiesel. Several optimization steps allowed for theselection of optimal reaction conditions to finally provide a simple and efficient process for the removal of SGs fromcrude biodiesel. The resulting biodiesel displayed filterability properties similar to distilled biodiesel according to thetotal contamination (TC), the cold soak filtration test (CSFT), filter blocking tendency (FBT), and cold soak filter blockingtendency (CSFBT) tests. The process was successfully scaled up to a 20 ton reactor, confirming its adaptability toindustrial settings.Conclusions: The results presented in this work provide a novel path for the removal of steryl glucosides from biodieselusing a cost-effective, environmentally friendly and scalable enzymatic process, contributing to the adoption ofthis renewable fuel.Fil: Peirú, Salvador. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina. Keclon; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Aguirre, Andres. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina. Keclon; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Eberhardt, Maria Florencia. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Braia, Mauricio Javier. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Cabrera, Rodolfo Ariel. Unitec Bio; ArgentinaFil: Menzella, Hugo Gabriel. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina. Keclon; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin

An algorithm based on 3-braids to solve tangle equations arising in the action of Gin DNA invertase

"The tangle model of Ernst and Sumners is an effective tool in the topological analysis of enzymes, a particular application of which aims at deducing the mechanism of action of site-specific recombination mediated by the Gin DNA invertase, an enzyme whose action involves 3-string tangles. In order to determine the enzyme’s mechanism of action, the tangle model yields equations that involve tangle indeterminates that must be solved for. While some of the available methods for solving such equations judiciously exploit the theory of 2-tangles, an algorithm is introduced in this note, based on 3-braid-theoretical results in [2], which allowed the authors to discover previously unreported solutions for the action of Gin DNA invertase. More generally, the algorithm allows one to solve 3-string tangle equations for 3-braid solutions under the assumption that each of the products of two or more rounds of recombinations is the unknot or a known 2-bridge knot different from the 2-component unlink. Rather than a specific language implementation, we here provide a pseudo-code description of the algorithm that permits its translation into a variety of computer languages and, possibly, its inclusion into more powerful analysis software.

Braid solutions to the action of the Gin enzyme

"The topological analysis of enzymes, an active research topic, has allowed the application of the tangle model of Ernst and Sumners to deduce the action mechanism of several enzymes, modeled as 2-string tangles. By first deriving some results in the theory of 3-braids, in this paper we analyze knotted and linked products of site-specific recombination mediated by the Gin DNA invertase, an enzyme that involves 3-string tangles. Provided that the 3-tangles involved are 3-braids, we determine four families of solutions to its action, two families for each of the directly and inversely repeated site cases. For each case, one of the given solutions had not previously been reported in the related literature. These solutions were found using a computer algorithm, based on our theoretical results, which allows one to solve tangle equations under the assumption that the product of two or more rounds of recombinations is known.

ENFERMEDAD DE OSGOOD-SCHLATTER Revisión de casos clínicos.

Introducción: La enfermedad de Osgood-Schlatter causa dolor en la cara anterior de la rodilla en algunos niños/niñas de entre 10 y 15 años que realizan actividades deportivas como fútbol, baloncesto, baile, etc, actividades que producen microtraumatismos repetidos por las contracciones de la musculatura del cuádriceps (Weiler, Ingram & Wolman, 2011) y del tendón rotuliano que se traduce en la fragmentación de la tuberosidad tibial y con inflamación (Lizárraga & Villalobos, 2007). Es una enfermedad autolimitada pero, en el adulto, origina una prominencia indolora en la región anterior de la rodilla. Objetivos: Establecer la causa, localización preferente de la de enfermedad de Osgood-Schlatter, su diagnóstico por imagen, su sintomatología y el tiempo de evolución. Material y métodos: Se ha llevado a cabo una revisión bibliográfica de casos clínicos sobre la enfermedad de Osgood-Schlatter mediante búsquedas en PubMed y Scopus, obteniendo 11 artículos con 12 pacientes. Resultados: La causa principal de OS es la tracción del tendón rotuliano y microtraumatismos sobre la tuberosidad tibial durante el ejercicio (83,33% de los pacientes). El diagnóstico del OS se realiza mediante pruebas por imagen, siendo la más utilizada la Rx lateral de rodilla. La edad media de los pacientes es de 13,66 ± 1,34 años. En nuestro estudio solo hay niños. Conclusiones: El 50% de los pacientes tienen afectación bilateral con inflamación y dolor acentuados durante la práctica deportiva. La Rx lateral de rodilla es la prueba por imagen más utilizada para el diagnóstico. El tratamiento suele ser conservador. El 50% de los pacientes tardan más de 6 meses en acudir a su primera consulta

Diseño y construcción de un prototipo de plataforma de venta automatizada (PVA)

The following document presents an answer for the continuous requirement of society to satisfy their necessity of buying certain products at the instant. In order to answer this requirement, it is necessary that different areas of engineering come together to obtain a complete and flexible solution; in this specific case, such areas are mechanical and automation, which have joined to obtain a product called Automatized Vending Platform (PVA by its acronym in Spanish), the same which is developed below, from the pre-design to the construction. The PVA passed through different stages to go from a sketch to a real prototype, and all those stages are detailed and justify.El siguiente documento presenta una respuesta al requerimiento constante de la sociedad actual por satisfacer la necesidad de adquirir ciertos productos al instante. Para poder responder a este requerimiento es necesario que diferentes áreas de la ingeniería se integren para obtener soluciones completas y flexibles; en este caso específico, la mecánica y la automatización se juntan para obtener un producto llamado Plataforma de Venta Automatizada (PVA), él mismo que se desarrolla a continuación, desde el pre-diseño hasta la construcción. La PVA pasó por las diferentes etapas necesarias para ir de un bosquejo a un prototipo real, siendo todas estas etapas descritas y justificadas

Temperature adaptation of Entamoeba histolytica and its effect on virulence

1. 1. Three strains (UC, 201, and 202) of E. histolytica were adapted to grow at low (29 [deg]C) and high (42.5 [deg]C) temperatures.2. 2. Encystment of strains 201 and UC was produced by returning the trophozoites from the temperatures of adaptation to the original normal growth temperature of 37 [deg]C.3. 3. Unadapted strains 201 and 202 of E. histolytica had a low degree of virulence for livers of hamsters, while the same strains adapted to low temperature were highly virulent.4. 4. The virulence of these adapted amebae was not lost by returning these parasites to their original normal growth temperature of 37 [deg]C for 6 weeks.5. 5. By adding the bacteria of the adapted culture to the unadapted amebae, a moderate increase in the virulence was produced.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/32488/1/0000574.pd

Hormonal regulation of female reproduction

Reproduction is an event that requires the coordination of peripheral organs with the nervous system to ensure that the internal and external environments are optimal for successful procreation of the species. This is accomplished by the hypothalamic-pituitary-gonadal axis that coordinates reproductive behavior with ovulation. The primary signal from the central nervous system is gonadotropin-releasing hormone (GnRH), which modulates the activity of anterior pituitary gonadotropes regulating follicle stimulating hormone (FSH) and luteinizing hormone (LH) release. As ovarian follicles develop they release estradiol, which negatively regulates further release of GnRH and FSH. As estradiol concentrations peak they trigger the surge release of GnRH, which leads to LH release inducing ovulation. Release of GnRH within the central nervous system helps modulate reproductive behaviors providing a node at which control of reproduction is regulated. To address these issues, this review focuses on several critical questions. How is the HPG axis regulated in species with different reproductive strategies? What internal and external conditions modulate the synthesis and release of GnRH? How does GnRH modulate reproductive behavior within the hypothalamus? How does disease shift the activity of the HPG axis.Fil: Christensen, A.. University of California at Los Angeles; Estados UnidosFil: Bentley, G. E.. University of California at Berkeley; Estados UnidosFil: Cabrera Kreiker, Ricardo Jorge. Universidad de Mendoza; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: Ortega, Hugo Hector. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Litoral; ArgentinaFil: Perfito, N.. University of California at Berkeley; Estados UnidosFil: Wu, T. J.. Uniformed Services University Of The Health Sciences; Estados UnidosFil: Micevych, P.. University of California at Los Angeles; Estados Unido