8 research outputs found

    Role of age and comorbidities in mortality of patients with infective endocarditis

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    [Purpose]: The aim of this study was to analyse the characteristics of patients with IE in three groups of age and to assess the ability of age and the Charlson Comorbidity Index (CCI) to predict mortality. [Methods]: Prospective cohort study of all patients with IE included in the GAMES Spanish database between 2008 and 2015.Patients were stratified into three age groups:<65 years,65 to 80 years,and ≥ 80 years.The area under the receiver-operating characteristic (AUROC) curve was calculated to quantify the diagnostic accuracy of the CCI to predict mortality risk. [Results]: A total of 3120 patients with IE (1327 < 65 years;1291 65-80 years;502 ≥ 80 years) were enrolled.Fever and heart failure were the most common presentations of IE, with no differences among age groups.Patients ≥80 years who underwent surgery were significantly lower compared with other age groups (14.3%,65 years; 20.5%,65-79 years; 31.3%,≥80 years). In-hospital mortality was lower in the <65-year group (20.3%,<65 years;30.1%,65-79 years;34.7%,≥80 years;p < 0.001) as well as 1-year mortality (3.2%, <65 years; 5.5%, 65-80 years;7.6%,≥80 years; p = 0.003).Independent predictors of mortality were age ≥ 80 years (hazard ratio [HR]:2.78;95% confidence interval [CI]:2.32–3.34), CCI ≥ 3 (HR:1.62; 95% CI:1.39–1.88),and non-performed surgery (HR:1.64;95% CI:11.16–1.58).When the three age groups were compared,the AUROC curve for CCI was significantly larger for patients aged <65 years(p < 0.001) for both in-hospital and 1-year mortality. [Conclusion]: There were no differences in the clinical presentation of IE between the groups. Age ≥ 80 years, high comorbidity (measured by CCI),and non-performance of surgery were independent predictors of mortality in patients with IE.CCI could help to identify those patients with IE and surgical indication who present a lower risk of in-hospital and 1-year mortality after surgery, especially in the <65-year group

    Spanish validation of the “Reading the Mind in the Voice” task: A study of complex emotion recognition in adults with autism spectrum conditions

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    Background: Social cognition includes a range of cognitive processes that help individuals understand how others think and feel. Recent proposals outline the relevance of this cognitive domain in a broad set of clinical pictures, as well as its diagnostic and prognostic value. In this study, we present the Spanish validation of the Reading the Mind in the Voice (RMV-SV) task, (Rutherford et al., 2002), an instrument for the recognition of mental states and complex emotions through prosody. Method: A group of adults diagnosed with autism spectrum disorders (ASD, n = 45) were compared to a control group from the general population (n = 51) in several emotion-recognition tasks. Results: The ASD group performed worse than controls overall on complex emotion and mental state recognition from voices (ŋ2 =.322; p <.01), statistically significant differences were found on 18/33 specific emotions. A positive correlation was found between verbal and nonverbal IQ and emotion recognition task scores. Using RMV-SV scores, 87.5% of the participants were correctly allocated to their original condition group. Conclusions: The results confirmed the alteration of the recognition of mental states and complex emotions by prosody among adults diagnosed with ASD. The RMV-SV showed suitable validity and reliability indexes, so the adapted task could facilitate the evaluation of complex emotion recognition through prosody in Spanis

    ¿Puedo cerrar la ventana?

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    Convocatoria proyectos de innovación de Extremadura 2020/2021Se presenta un proyecto que intentaba dar soluciones a la transmisión del virus SARS-CoV-2 en el IES Santiago Apostol de Almendralejo. Ante las evidencias científicas que sostenían su transmisión por el aire se plantea la medición de CO2 y distintas estrategias de ventilación posibles que minimicen el contagio del virus y sean viables económicamente. Además, se pretende concienciar a la comunidad educativa de la importancia de la ventilación en la salud. Otros objetivos del proyecto eran: promover que el alumno sea capaz de aprender por sí mismo; trabajar utilizando las etapas del método científico que se trabajan desde todas las áreas del conocimiento: Microbiología, Química Analítica, Matemáticas, Física y Química, Plástica, Informática, etc.; fomentar y promocionar la investigación; promover el trabajo colaborativo; potenciar las metodologías activas; generar reflexión social con la que poder dar respuestas a los problemas sociales de cada momento, etc.ExtremaduraES

    Infective Endocarditis in Patients With Bicuspid Aortic Valve or Mitral Valve Prolapse

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    Sign of the Cross: contexts for the Ivory Cross of San Millán de la Cogolla

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    Contemporary use of cefazolin for MSSA infective endocarditis: analysis of a national prospective cohort

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    Objectives: This study aimed to assess the real use of cefazolin for methicillin-susceptible Staphylococcus aureus (MSSA) infective endocarditis (IE) in the Spanish National Endocarditis Database (GAMES) and to compare it with antistaphylococcal penicillin (ASP). Methods: Prospective cohort study with retrospective analysis of a cohort of MSSA IE treated with cloxacillin and/or cefazolin. Outcomes assessed were relapse; intra-hospital, overall, and endocarditis-related mortality; and adverse events. Risk of renal toxicity with each treatment was evaluated separately. Results: We included 631 IE episodes caused by MSSA treated with cloxacillin and/or cefazolin. Antibiotic treatment was cloxacillin, cefazolin, or both in 537 (85%), 57 (9%), and 37 (6%) episodes, respectively. Patients treated with cefazolin had significantly higher rates of comorbidities (median Charlson Index 7, P <0.01) and previous renal failure (57.9%, P <0.01). Patients treated with cloxacillin presented higher rates of septic shock (25%, P = 0.033) and new-onset or worsening renal failure (47.3%, P = 0.024) with significantly higher rates of in-hospital mortality (38.5%, P = 0.017). One-year IE-related mortality and rate of relapses were similar between treatment groups. None of the treatments were identified as risk or protective factors. Conclusion: Our results suggest that cefazolin is a valuable option for the treatment of MSSA IE, without differences in 1-year mortality or relapses compared with cloxacillin, and might be considered equally effective

    Mural Endocarditis: The GAMES Registry Series and Review of the Literature

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