Three to Tango: Inhibitory Effect of Quercetin and Apigenin on Acetylcholinesterase, Amyloid-β Aggregation and Acetylcholinesterase-Amyloid Interaction

One of the pathological hallmarks of Alzheimer's disease (AD) is the formation of amyloid-β plaques. Since acetylcholinesterase (AChE) promotes the formation of such plaques, the inhibition of this enzyme could slow down the progression of amyloid-β aggregation, hence being complementary to the palliative treatment of cholinergic decline. Anti-aggregation assays performed for apigenin and quercetin, which are polyphenolic compounds that exhibit inhibitory properties against the formation of amyloid plaques, reveal distinct inhibitory effects of these compounds on Aβ40 aggregation in the presence and absence of AChE. Furthermore, the analysis of the amyloid fibers formed in the presence of these flavonoids suggests that the Aβ40 aggregates present different quaternary structures, viz., smaller molecular assemblies are generated. In agreement with a non-competitive inhibition of AChE, molecular modeling studies indicate that these effects may be due to the binding of apigenin and quercetin at the peripheral binding site of AChE. Since apigenin and quercetin can also reduce the generation of reactive oxygen species, the data achieved suggest that multitarget catechol-type compounds may be used for the simultaneous treatment of various biological hallmarks of AD

Primary care randomized clinical trial: manual therapy effectiveness in comparison with TENS in patients with neck pain

This study investigated effectiveness of manual therapy (MT) with transcutaneous electrical nerve stimulation (TENS) to reduce pain intensity in patients with mechanical neck disorder (MND). A randomized multi-centered controlled clinical trial was performed in 12 Primary Care Physiotherapy Units in Madrid Region. Ninety patients were included with diagnoses of subacute or chronic MND without neurological damage, 47 patients received MT and 43 TENS. The primary outcome was pain intensity measured in millimeters using the Visual Analogue Scale (VAS). Also disability, quality of life, adverse effects and sociodemographic and prognosis variables were measured. Three evaluations were performed (before, when the procedure ?nished and six months after). Seventy-one patients (79%) completed the follow-up measurement at six months. In more than half of the treated patients the procedure had a clinically relevant ?short term? result after having ended the intervention, when either MT or TENS was used. The success rate decreased to one-third of the patients 6 months after the intervention. No differences can be found in the reduction of pain, in the decrease of disability nor in the quality of life between both therapies. Both analyzed physiotherapy techniques produce a short-term pain reduction that is clinically relevant.Ministerio de SanidadInstituto de Salud Carlos II

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Role of age and comorbidities in mortality of patients with infective endocarditis

[Purpose]: The aim of this study was to analyse the characteristics of patients with IE in three groups of age and to assess the ability of age and the Charlson Comorbidity Index (CCI) to predict mortality. [Methods]: Prospective cohort study of all patients with IE included in the GAMES Spanish database between 2008 and 2015.Patients were stratified into three age groups:<65 years,65 to 80 years,and ≥ 80 years.The area under the receiver-operating characteristic (AUROC) curve was calculated to quantify the diagnostic accuracy of the CCI to predict mortality risk. [Results]: A total of 3120 patients with IE (1327 < 65 years;1291 65-80 years;502 ≥ 80 years) were enrolled.Fever and heart failure were the most common presentations of IE, with no differences among age groups.Patients ≥80 years who underwent surgery were significantly lower compared with other age groups (14.3%,65 years; 20.5%,65-79 years; 31.3%,≥80 years). In-hospital mortality was lower in the <65-year group (20.3%,<65 years;30.1%,65-79 years;34.7%,≥80 years;p < 0.001) as well as 1-year mortality (3.2%, <65 years; 5.5%, 65-80 years;7.6%,≥80 years; p = 0.003).Independent predictors of mortality were age ≥ 80 years (hazard ratio [HR]:2.78;95% confidence interval [CI]:2.32–3.34), CCI ≥ 3 (HR:1.62; 95% CI:1.39–1.88),and non-performed surgery (HR:1.64;95% CI:11.16–1.58).When the three age groups were compared,the AUROC curve for CCI was significantly larger for patients aged <65 years(p < 0.001) for both in-hospital and 1-year mortality. [Conclusion]: There were no differences in the clinical presentation of IE between the groups. Age ≥ 80 years, high comorbidity (measured by CCI),and non-performance of surgery were independent predictors of mortality in patients with IE.CCI could help to identify those patients with IE and surgical indication who present a lower risk of in-hospital and 1-year mortality after surgery, especially in the <65-year group

Nuevos materiales metalorgánicos basados en Triazolopirimidinas

Tesis Univ. Granada. Departamento de Química Inorgánica. Leída el 15 de diciembre del 201

Complejos metálicos con actividad antiparasitaria

Número de publicación: 2436220. Número de solicitud: 201331704.La presente invención se refiere a unos complejos metálicos coordinados con al menos un ligando 5,7-dimetil-1,2,4-triazolo[1,5-a]pirimidina, además la invención también se refiere al uso de estos complejos para el tratamiento de enfermedades parasitarías y más particularmente de leishmaniasis o enfermedad de Chagas.Universidad de Granad

De la necesidad, oportunidad : propuestas metodológicas para los nuevos tiempos

Se recogen una serie de propuestas surgidas a partir del curso de formación del profesorado «Metodologías emergentes» realizado en la Universidad de Barcelona. A partir de la presentación y contraste de algunas de las metodologías activas que son tendencia en la Educación Superior, se establece un interesante y enriquecedor debate e intercambio de experiencia e inquietudes entre los participantes del grupo. Un debate en torno a las propuestas que ayudan a estimular más y mejor el aprendizaje de los estudiantes y que facilita poner nombre y situar muchas de las acciones formativas innovadoras que ya se están llevando a cabo, o contrastar qué aprendizajes y soluciones se han validado ya en la práctica aplicando algunas de estas estrategias para motivar a los estudiantes, o inspirarnos en propuestas que se plantean desde estudios diferentes y que nos descubren una nueva perspectiva o mirada para aplicar a las asignaturas propias.Biblioteca del Ministerio de Educación y Formación Profesional; Calle San Agustín, 5; 28014 Madrid; Tel. +34917748000; [email protected]

Desarrollo del Proyecto Curricular a través de la Educación Ambiental, canarios y huerto

Proyecto de Educación Ambiental que se centra, como años anteriores, en el mantenimiento del huerto y en el cuidado y crianza de canarios. Pretende fomentar la integración de toda la comunidad educativa del centro; aprender,con la práctica diaria los cuidados de los canarios y las labores del huerto; reconocer los cambios de los canarios y de las plantas en las cuatro estaciones mediante la observación sistemática, identificando sus características básicas; elaborar normas prácticas para el uso, cuidado y mantenimiento de los materiales empleados; incorporar el proyecto como recurso didáctico al desarrollo del proyecto curricular.Madrid (Comunidad Autónoma). Consejería de Educación y CulturaMadridMadrid (Comunidad Autónoma). Subdirección General de Formación del Profesorado. CRIF Las Acacias; General Ricardos 179 - 28025 Madrid; Tel. + 34915250893ES

PARTIC : Memoria 2003-04

El trabajo no ha sido publicado. Resumen basado en ficha elaborada por los autores. La memoria (electrónica) adjunta está en distinto formato a la impresa (diapositivas del Power Point), pero el contenido es el mismo.El trabajo se realiza en el CEIP Pintor Aguastín Riancho, centro al que pertenecen los 17 profesores que han sido partícipes del proyecto. Los objetivos que se pretenden alcanzar son: posibilitar a los alumnos el uso de las TIC; formar alumnos capaces de utilizar las nuevas tecnologías como una herramienta mas de acceso a la información y al conocimiento; normalizar el uso de las nuevas tecnologías en el colegio; disponer de los avances científicos proporcionados por las nuevas tecnologías; generar juicios críticos (posicionales) sobre la informática. Estos objetivos, se intentan conseguir por medio de la integración del ordenador como recurso de afianzamiento y complemento de los contenidos curriculares de cada área, realizando fichas de evaluación de los programas software por ciclos, y con la formación de la utilización de Internet, direcciones Web, etc. La evaluación de los profesores considera que el proyecto favorece el aprendizaje y disminuye el fracaso escolar, así como fomenta el trabajo en equipo.Consejería de Educación y Juventud de CantabriaCantabriaES

Leemos y representamos : La serrana de la Vera

En el documento no aparece fecha de publicaciónSe recopilan un conjunto de adaptaciones del romance 'La serrana de la Vera': un cuento, una versión actualizada y un guión de teatro, que sirven como base para llevar a cabo distintas actividades con los alumnos. El objetivo principal del material era: dar a conocer las manifestaciones culturales y folclóricas típicas de la comarca de la Vera de una forma lúdica a través de esta leyenda.ExtremaduraCPR de Navalmoral de la Mata (Cáceres); Avda. San Isidro, 10; Apdo. 221; 10300 Navalmoral de la Mata (Cáceres); +34927016720; +34927016721; [email protected]