Final state interaction effects in neutrino-nucleus quasielastic scattering

We consider the charged-current quasielastic scattering of muon neutrinos on an Oxygen 16 target, described within a relativistic shell model and, for comparison, the relativistic Fermi gas. Final state interactions are described in the distorted wave impulse approximation, using both a relativistic mean field potential and a relativistic optical potential, with and without imaginary part. We present results for inclusive cross sections at fixed neutrino energies in the range $E_\nu =$ 200 MeV - 1 GeV, showing that final state interaction effects can remain sizable even at large energies.Comment: 4 pages, 4 figures; poster session of the Third International Workshop on Neutrino-Nucleus Interactions in the Few GeV Region (NuInt04), Gran Sasso (Italy), March 17-21, 2004; to appear in the proceeding

New cytogenetic prognostic markers in breast cancer

Abstract BACKGROUND: The aim of this study was to identify chromosomal imbalances in a series of invasive ductal carcinomas. In order to characterize the prognostic value of the chromosomal aberrations, we determined the association between genetic changes, overall survival, recurrences and some well-known prognostic and diagnostic parameters. MATERIAL AND METHODS: We included in this study 70 ductal invasive carcinomas diagnosed at the Hospital of Navarra during 1991-1994. We used the Comparative Genomic Hybridization Technique (CGH) for the molecular cytogenetic analysis of formalin-fixed, paraffin embedded specimens. RESULTS: We obtained successful results in 57 out of 70 cases (81.4%). The most frequent recurring findings were DNA gains on 8q, 17q, 1q, 20q, 11q and 6q and losses on 16q, Xp, Xq, 13q, 11q and 8p. In the survival study, gains on 1q and 11q13 were more frequent in patients with recurrence (41.3% vs. 18.5% and 50% vs. 23.7%). Loss of 16q appears as a prognostic factor of good outcome because of its association with good pathological prognostic features: 100% of tumors with this aberration showed overexpression of Bcl-2, and 75% of them were node negative. Besides, 46.7% of the positive cases for the expression of estrogen receptors also showed this imbalance. CONCLUSIONS: The CGH is a useful technique for the study of paraffin embedded tumors. Our results confirm that the cytogenetic aberrations of tumors could be considered as prognostic factors contributing to a better knowledge of tumor outcome

Genomic imbalances detected by comparative genomic hybridization are prognostic markers in invasive ductal breast carcinomas

AIMS: The aim of this work is the study of the prognostic significance of the chromosomal aberrations described in a series of invasive ductal breast carcinomas. METHODS AND RESULTS: We analysed by comparative genomic hybridization a group of 70 formalin-fixed paraffin-embedded invasive ductal breast carcinomas. Aberrations showed a frequency similar to previous studies using frozen tumours. Interestingly, we identified gains involving 6q16-q24 more frequently than in other series. We analysed the association among the chromosomal imbalances, 11 histopathological factors, relapse rate and overall survival of patients. Associations showed 16q losses as a potential marker of good prognosis, as they were more frequent in node-negative (P=0.025) and in oestrogen-positive tumours (P < 0.001). Furthermore, 100% of bcl-2+ tumours presented this aberration compared with 29.3% in bcl-2- (P=0.014). 1q, 11q, 17q and 20q gains were associated with poor prognosis: 95% of cases with 1q gains were bigger than 20 mm (P=0.041). Tumours with 1q and 11q gains showed a higher relapse rate (P=0.063; P=0.066). Within the good prognosis group of lymph node-negative patients, 17q and 20q gains identify a subgroup with increased relapse rate (P=0.039). CONCLUSIONS: Chromosomal imbalances, together with histopathological factors, may help to predict outcome in breast cancer patients

Superscaling analysis of the Coulomb Sum Rule in quasielastic electron-nucleus scattering

The Coulomb sum rule for inclusive quasielastic electron scattering in $^{12}$C, $^{40}$Ca and $^{56}$Fe is analyzed based on scaling and superscaling properties. Results obtained in the relativistic impulse approximation with various descriptions of the final state interactions are shown. A comparison with experimental data measured at Bates and Saclay is provided. The theoretical description based on strong scalar and vector terms present in the relativistic mean field, which has been shown to reproduce the experimental asymmetric superscaling function, leads to results that are in fair agreement with Bates data while it sizeably overestimates Saclay data. We find that the Coulomb sum rule for a momentum transfer $q\geq 500$ $MeV/c$ saturates to a value close to 0.9, being very similar for the three nuclear systems considered. This is in accordance with Bates data, which indicates that these show no significative quenching in the longitudinal response.Comment: 22 pages, 6 figures. To be published in Phys. Lett.

Test de activación de basófilos en el diagnóstico de alergia a medicamentos

In this paper we study the reliability of the basophil activation test (BAT) in the "in-vitro" diagnosis of allergy to betalactams and to metamizol, and the sensitivity and specificity of the technique are analyzed. To this end, we studied 58 patients allergic to betalactam antibiotics with a positive cutaneous test facing any derivative of penicillin and 30 healthy controls who tolerated betalactams, and 26 patients allergic to metamizol with an immediate reaction and 30 healthy controls who tolerated the medicine. Sensitivity to BAT in allergy to betalactams was 52.8%, and specificity was 92.6%. For metamizol, sensitivity was 42.3% and specificity was 100%. The positive predictive value of BAT in allergy to betalactams was 18.9% and the negative predictive value was 98.4%. For metamizol, the positive predictive value of the technique was 100% and the negative predictive value was 99.4%. The joint use of BAT and CAP (specific IgE) makes it possible to diagnose some 65% of patients allergic to betalactams. The combined use of cutaneous tests and BAT in allergy to metamizol detects 70% of the cases. BAT is a useful, non-invasive technique in the "in-vitro" diagnosis of allergy to betalactams and metamizol

Nuclear transparencies in relativistic A(e,e'p) models

Relativistic and unfactorized calculations for the nuclear transparency extracted from exclusive A(e,e'p) reactions for 0.3 \leq Q^2 \leq 10 (GeV/c)^2 are presented for the target nuclei C, Si, Fe and Pb. For Q^2 \geq 0.6 (GeV/c)^2, the transparency results are computed within the framework of the recently developed relativistic multiple-scattering Glauber approximation (RMSGA). The target-mass and Q^2 dependence of the RMSGA predictions are compared with relativistic distorted-wave impulse approximation (RDWIA) calculations. Despite the very different model assumptions underlying the treatment of the final-state interactions in the RMSGA and RDWIA frameworks, they predict comparable nuclear transparencies for kinematic regimes where both models are applicable.Comment: 15 pages, 4 figure

Meson Exchange Currents in (e,e'p) recoil polarization observables

A study of the effects of meson-exchange currents and isobar configurations in $A(\vec{e},e'\vec{p})B$ reactions is presented. We use a distorted wave impulse approximation (DWIA) model where final-state interactions are treated through a phenomenological optical potential. The model includes relativistic corrections in the kinematics and in the electromagnetic one- and two-body currents. The full set of polarized response functions is analyzed, as well as the transferred polarization asymmetry. Results are presented for proton knock-out from closed-shell nuclei, for moderate to high momentum transfer.Comment: 44 pages, 18 figures. Added physical arguments explaining the dominance of OB over MEC, and a summary of differences with previous MEC calculations. To be published in PR

Evaluación de los efectos de la incorporación de las herramientas web 2.0 en el diseño de nuestra práctica docente

A lo largo del curso 2011/2012, un grupo de profesores venimos desarrollando un Proyecto De Innovación y Mejora de la Calidad Docente, subvencionado por la Universidad Complutense (PIMCD nº 169) cuya finalidad es diseñar y desarrollar, para la asignatura “Orientación educativa y Acción tutorial” del grado de Maestro, propuestas metodológicas que incorporen diferentes herramientas colaborativas en línea (herramientas web 2.0) para potenciar el trabajo colaborativo y para facilitar el aprendizaje significativo. Tres son los ejes que están centrando nuestro trabajo: 1. Formación del profesorado para el uso de herramientas web 2.0. 2. Diseño: integración de lo aprendido para el diseño de propuestas metodológicas apoyadas en el uso de dichas herramientas. 3. Evaluación del proceso: análisis crítico de las efectos que la incorporación de las herramientas web 2.0 pueda tener en la mejora de nuestra competencia y los beneficios para el aprendizaje de nuestros estudiantes. Esta evaluación, a su vez, se focalizará en dos cuestiones: mejora de la competencia digital de los profesores (conocimiento y maneo de las herramientas web 2.0) y valoración de los materiales diseñados para su utilización en el aula, analizando los beneficios que la utilización de herramientas 2.0 puede tener en el logro de un aprendizaje significativo por parte del alumnado. El trabajo que presentamos a continuación hacer referencia a la valoración de las actividades diseñadas para uno de los grupos de docencia con los que hemos venido trabajando durante el curso 2011- 2012.Peer Reviewe