Microtexture studies of PST and PZT ceramics and PZT thin film by electron backscatter diffraction patterns

Author name used in this publication: C. W. Tai2002-2003 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

Radiation damage by Ar⁺ ion-milling in ferroelectric oxides

2005-2006 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

Effects of Repeated Central Administration of Endothelin Type A Receptor Antagonist on the Development of Neuropathic Pain in Rats

published_or_final_versio

Crosstalk between astrocytic CXCL12 and microglial CXCR4 contributes to the development of neuropathic pain

published_or_final_versio

Observation of the structure of iridescent surface layer on chalcopyrite

2005-2006 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

Preventive Treatment with Ketamine attenuates the ischaemia-reperfusion response in a chronic postichaemia pain model

published_or_final_versio

Central administration of C-x-C chemokine receptor type 4 antagonist alleviates the development and maintenance of peripheral neuropathic pain in mice

Aim To explore the roles of C-X-C chemokine receptor type 4 (CXCR4) in spinal processing of neuropathic pain at the central nervous system (CNS). Methods Peripheral neuropathic pain (PNP) induced by partial sciatic nerve ligation (pSNL) model was assessed in mice. Effects of a single intrathecal (central) administration of AMD3100 (intrathecal AMD3100), a CXCR4 antagonist, on pain behavior and pain-related spinal pathways and molecules in the L3-L5 spinal cord segment was studied compare to saline treatment. Results Rotarod test showed that intrathecal AMD3100 did not impair mice motor function. In pSNL-induced mice, intrathecal AMD3100 delayed the development of mechanical allodynia and reversed the established mechanical allodynia in a dose-dependent way. Moreover, intrathecal AMD3100 downregulated the activation of JNK1 and p38 pathways and the protein expression of p65 as assessed by western blotting. Real-time PCR test also demonstrated that substance P mRNA was decreased, while adrenomedullin and intercellular adhesion molecule mRNA was increased following AMD3100 treatment. Conclusion Our results suggest that central (spinal) CXCR4 is involved in the development and maintenance of PNP and the regulation of multiple spinal molecular events under pain condition, implicating that CXCR4 would potentially be a therapeutic target for chronic neuropathic pain.published_or_final_versio

Rapid detection of BRCA1/2 recurrent mutations in Chinese breast and ovarian cancer patients with multiplex SNaPshot genotyping panels.

BRCA1/2 mutations are significant risk factors for hereditary breast and ovarian cancer (HBOC), its mutation frequency in HBOC of Chinese ethnicity is around 9%, in which nearly half are recurrent mutations. In Hong Kong and China, genetic testing and counseling are not as common as in the West. To reduce the barrier of testing, a multiplex SNaPshot genotyping panel that targeted 25 Chinese BRCA1/2 mutation hotspots was developed, and its feasibility was evaluated in a local cohort of 441 breast and 155 ovarian cancer patients. For those who tested negative, they were then subjected to full-gene testing with next-generation sequencing (NGS). BRCA mutation prevalence in this cohort was 8.05% and the yield of the recurrent panel was 3.52%, identifying over 40% of the mutation carriers. Moreover, from 79 Chinese breast cancer cases recruited overseas, 2 recurrent mutations and one novel BRCA2 mutation were detected by the panel and NGS respectively. The developed genotyping panel showed to be an easy-to-perform and more affordable testing tool that can provide important contributions to improve the healthcare of Chinese women with cancer as well as family members that harbor high risk mutations for HBOC

Inhibition Of Spinal Endothelin Type A Receptor Ameliorates Neuropathic Pain Through Down-regulation Of Mapk And Nf--κappab P65 In Rats

Conference Theme: Translating Evidence into PracticeLate-Breaking Poster Session 3: abstract no. EFIC5-1288 / Poster board no. 508published_or_final_versio

Positive symptoms and white matter microstructure in never-medicated first episode schizophrenia

Author name used in this publication: V. Cheung2010-2011 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe