2,782 research outputs found
Mining Partially-Ordered Sequential Rules Common to Multiple Sequences
© 2015 IEEE. Sequential rule mining is an important data mining problem with multiple applications. An important limitation of algorithms for mining sequential rules common to multiple sequences is that rules are very specific and therefore many similar rules may represent the same situation. This can cause three major problems: (1) similar rules can be rated quite differently, (2) rules may not be found because they are individually considered uninteresting, and (3) rules that are too specific are less likely to be used for making predictions. To address these issues, we explore the idea of mining "partially-ordered sequential rules" (POSR), a more general form of sequential rules such that items in the antecedent and the consequent of each rule are unordered. To mine POSR, we propose the RuleGrowth algorithm, which is efficient and easily extendable. In particular, we present an extension (TRuleGrowth) that accepts a sliding-window constraint to find rules occurring within a maximum amount of time. A performance study with four real-life datasets show that RuleGrowth and TRuleGrowth have excellent performance and scalability compared to baseline algorithms and that the number of rules discovered can be several orders of magnitude smaller when the sliding-window constraint is applied. Furthermore, we also report results from a real application showing that POSR can provide a much higher prediction accuracy than regular sequential rules for sequence prediction
Factorization and resummation of s-channel single top quark production
In this paper we study the factorization and resummation of s-channel single
top quark production in the Standard Model at both the Tevatron and the LHC. We
show that the production cross section in the threshold limit can be factorized
into a convolution of hard function, soft function and jet function via
soft-collinear-effective-theory (SCET), and resummation can be performed using
renormalization group equation in the momentum space resummation formalism. We
find that in general, the resummation effects enhance the Next-to-Leading-Order
(NLO) cross sections by about at both the Tevatron and the LHC, and
significantly reduce the factorization scale dependence of the total cross
section at the Tevatron, while at the LHC we find that the factorization scale
dependence has not been improved, compared with the NLO results.Comment: 29 pages, 7 figures; version published in JHE
Explanation of the Colour Change in Alexandrites.
Alexandrites are remarkable and rare gemstones. They display an extraordinary colour change according to the ambient lighting, from emerald green in daylight to ruby red in incandescent light from tungsten lamps or candles. While this colour change has been correctly attributed to chromium impurities and their absorption band in the yellow region of the visible light spectrum, no adequate explanation of the mechanism has been given. Here, the alexandrite effect is fully explained by considering the von Kries model of the human colour constancy mechanism. This implies that our colour constancy mechanism is real (objective) and primarily attuned to correct for the colour temperature of black-body illuminants
Spawning rings of exceptional points out of Dirac cones
The Dirac cone underlies many unique electronic properties of graphene and
topological insulators, and its band structure--two conical bands touching at a
single point--has also been realized for photons in waveguide arrays, atoms in
optical lattices, and through accidental degeneracy. Deformations of the Dirac
cone often reveal intriguing properties; an example is the quantum Hall effect,
where a constant magnetic field breaks the Dirac cone into isolated Landau
levels. A seemingly unrelated phenomenon is the exceptional point, also known
as the parity-time symmetry breaking point, where two resonances coincide in
both their positions and widths. Exceptional points lead to counter-intuitive
phenomena such as loss-induced transparency, unidirectional transmission or
reflection, and lasers with reversed pump dependence or single-mode operation.
These two fields of research are in fact connected: here we discover the
ability of a Dirac cone to evolve into a ring of exceptional points, which we
call an "exceptional ring." We experimentally demonstrate this concept in a
photonic crystal slab. Angle-resolved reflection measurements of the photonic
crystal slab reveal that the peaks of reflectivity follow the conical band
structure of a Dirac cone from accidental degeneracy, whereas the complex
eigenvalues of the system are deformed into a two-dimensional flat band
enclosed by an exceptional ring. This deformation arises from the dissimilar
radiation rates of dipole and quadrupole resonances, which play a role
analogous to the loss and gain in parity-time symmetric systems. Our results
indicate that the radiation that exists in any open system can fundamentally
alter its physical properties in ways previously expected only in the presence
of material loss and gain
Discovery of a potent deubiquitinase (DUB) small molecule activity‐based probe enables broad spectrum DUB activity profiling in living cells
Deubiquitinases (DUBs) are a family of >100 proteases that hydrolyze isopeptide bonds linking ubiquitin to protein substrates. This leads to reduced substrate degradation through the ubiquitin proteasome system. Deregulation of DUB activity has been implicated in many diseases, including cancer, neurodegeneration and auto-inflammation, and several have been recognized as attractive targets for therapeutic intervention. Ubiquitin-derived covalent activity-based probes (ABPs) provide a powerful tool for DUB activity profiling, but their large recognition element impedes cellular permeability and presents an unmet need for small molecule ABPs which can account for regulation of DUB activity in intact cells or organisms. Here, through comprehensive chemoproteomic warhead profiling, we identify cyanopyrrolidine (CNPy) probe IMP-2373 (12) as a small molecule pan-DUB ABP to monitor DUB activity in physiologically relevant live cells. Through proteomics and targeted assays, we demonstrate that IMP-2373 quantitatively engages more than 35 DUBs across a range of non-toxic concentrations in diverse cell lines. We further demonstrate its application to quantification of changes in intracellular DUB activity during pharmacological inhibition and during MYC deregulation in a model of B cell lymphoma. IMP-2373 thus offers a complementary tool to ubiquitin ABPs to monitor dynamic DUB activity in the context of disease-relevant phenotypes
Characterization of intrinsic properties of cingulate pyramidal neurons in adult mice after nerve injury
The anterior cingulate cortex (ACC) is important for cognitive and sensory functions including memory and chronic pain. Glutamatergic excitatory synaptic transmission undergo long-term potentiation in ACC pyramidal cells after peripheral injury. Less information is available for the possible long-term changes in neuronal action potentials or intrinsic properties. In the present study, we characterized cingulate pyramidal cells in the layer II/III of the ACC in adult mice. We then examined possible long-term changes in intrinsic properties of the ACC pyramidal cells after peripheral nerve injury. In the control mice, we found that there are three major types of pyramidal cells according to their action potential firing pattern: (i) regular spiking (RS) cells (24.7%), intrinsic bursting (IB) cells (30.9%), and intermediate (IM) cells (44.4%). In a state of neuropathic pain, the population distribution (RS: 21.3%; IB: 31.2%; IM: 47.5%) and the single action potential properties of these three groups were indistinguishable from those in control mice. However, for repetitive action potentials, IM cells from neuropathic pain animals showed higher initial firing frequency with no change for the properties of RS and IB neurons from neuropathic pain mice. The present results provide the first evidence that, in addition to synaptic potentiation reported previously, peripheral nerve injury produces long-term plastic changes in the action potentials of cingulate pyramidal neurons in a cell type-specific manner
Complex-Distance Potential Theory and Hyperbolic Equations
An extension of potential theory in R^n is obtained by continuing the
Euclidean distance function holomorphically to C^n. The resulting Newtonian
potential is generated by an extended source distribution D(z) in C^n whose
restriction to R^n is the delta function. This provides a natural model for
extended particles in physics. In C^n, interpreted as complex spacetime, D(z)
acts as a propagator generating solutions of the wave equation from their
initial values. This gives a new connection between elliptic and hyperbolic
equations that does not assume analyticity of the Cauchy data. Generalized to
Clifford analysis, it induces a similar connection between solutions of
elliptic and hyperbolic Dirac equations. There is a natural application to the
time-dependent, inhomogeneous Dirac and Maxwell equations, and the
`electromagnetic wavelets' introduced previously are an example.Comment: 25 pages, submited to Proceedings of 5th Intern. Conf. on Clifford
Algebras, Ixtapa, June 24 - July 4, 199
A 115-bp MethyLight assay for detection of p16 (CDKN2A) methylation as a diagnostic biomarker in human tissues
<p>Abstract</p> <p>Background</p> <p><it>p16 </it>Methylation is a potential biomarker for prediction of malignant transformation of epithelial dysplasia. A probe-based, quantitative, methylation-specific PCR (MSP) called MethyLight may become an eligible method for detecting this marker clinically. We studied oral mucosa biopsies with epithelial dysplasia from 78 patients enrolled in a published 4-years' followup cohort, in which cancer risk for patients with <it>p16 </it>methylation-positive dysplasia was significantly higher than those without <it>p16 </it>methylation (by 150-bp MSP and bisulfite sequencing; +133 ~ +283, transcription starting site, +1). The <it>p16 </it>methylation status in samples (<it>N </it>= 102) containing sufficient DNA was analyzed by the 70-bp classic (+238 ~ +307) and 115-bp novel (+157 ~ +272) MethyLight assays, respectively.</p> <p>Results</p> <p><it>p16 </it>Methylation was detectable in 75 samples using the classic MethyLight assay. The methylated-<it>p16 </it>positive rate and proportion of methylated-<it>p16 </it>by the MethyLight in MSP-positive samples were higher than those in MSP-negative samples (positive rate: 37/44 vs. 38/58, <it>P</it>=0.035, two-sided; proportion [median]: 0.78 vs. 0.02, <it>P <</it>0.007). Using the published results of MSP as a golden standard, we found sensitivity, specificity, and accuracy for this MethyLight assay to be 70.5%, 84.5%, and 55.0%, respectively. Because amplicon of the classic MethyLight procedure only partially overlapped with the MSP amplicon, we further designed a 115-bp novel MethyLight assay in which the amplicon on the sense-strand fully overlapped with the MSP amplicon on the antisense-strand. Using the 115-bp MethyLight assay, we observed methylated-<it>p16 </it>in 26 of 44 MSP-positive samples and 2 of 58 MSP-negative ones (<it>P </it>= 0.000). These results were confirmed with clone sequencing. Sensitivity, specificity, and accuracy using the 115-bp MethyLight assay were 59.1%, 98.3%, and 57.4%, respectively. Significant differences in the oral cancer rate were observed during the followup between patients (≥60 years) with and without methylated-<it>p16 </it>as detected by the 115-bp MethyLight assay (6/8 vs. 6/22, P = 0.034, two-sided).</p> <p>Conclusions</p> <p>The 115-bp MethyLight assay is a useful and practical assay with very high specificity for the detection of <it>p16 </it>methylation clinically.</p
Structure of hadron resonances with a nearby zero of the amplitude
We discuss the relation between the analytic structure of the scattering
amplitude and the origin of an eigenstate represented by a pole of the
amplitude.If the eigenstate is not dynamically generated by the interaction in
the channel of interest, the residue of the pole vanishes in the zero coupling
limit. Based on the topological nature of the phase of the scattering
amplitude, we show that the pole must encounter with the
Castillejo-Dalitz-Dyson (CDD) zero in this limit. It is concluded that the
dynamical component of the eigenstate is small if a CDD zero exists near the
eigenstate pole. We show that the line shape of the resonance is distorted from
the Breit-Wigner form as an observable consequence of the nearby CDD zero.
Finally, studying the positions of poles and CDD zeros of the KbarN-piSigma
amplitude, we discuss the origin of the eigenstates in the Lambda(1405) region.Comment: 7 pages, 3 figures, v2: published versio
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