The dark matter component of the Gaia radially anisotropic substructure

We study the properties of the dark matter component of the radially anisotropic stellar population recently identified in the Gaia data, using magneto-hydrodynamical simulations of Milky Way-like halos from the Auriga project. We identify 10 simulated galaxies that approximately match the rotation curve and stellar mass of the Milky Way. Four of these have an anisotropic stellar population reminiscent of the Gaia structure. We find an anti-correlation between the dark matter mass fraction of this population in the Solar neighbourhood and its orbital anisotropy. We estimate the local dark matter density and velocity distribution for halos with and without the anisotropic stellar population, and use them to simulate the signals expected in future xenon and germanium direct detection experiments. We find that a generalized Maxwellian distribution fits the dark matter halo integrals of the Milky Way-like halos containing the radially anisotropic stellar population. For dark matter particle masses below approximately 10 GeV, direct detection exclusion limits for the simulated halos with the anisotropic stellar population show a mild shift towards smaller masses compared to the commonly adopted Standard Halo Model

Radical SAM enzyme QueE defines a new minimal core fold and metal-dependent mechanism

7-carboxy-7-deazaguanine synthase (QueE) catalyzes a key S-adenosyl-L-methionine (AdoMet)- and Mg[superscript 2+]-dependent radical-mediated ring contraction step, which is common to the biosynthetic pathways of all deazapurine-containing compounds. QueE is a member of the AdoMet radical superfamily, which employs the 5′-deoxyadenosyl radical from reductive cleavage of AdoMet to initiate chemistry. To provide a mechanistic rationale for this elaborate transformation, we present the crystal structure of a QueE along with structures of pre- and post-turnover states. We find that substrate binds perpendicular to the [4Fe-4S]-bound AdoMet, exposing its C6 hydrogen atom for abstraction and generating the binding site for Mg[superscript 2+], which coordinates directly to the substrate. The Burkholderia multivorans structure reported here varies from all other previously characterized members of the AdoMet radical superfamily in that it contains a hypermodified ([β [subscript 6] over α [subscript 3]]) protein core and an expanded cluster-binding motif, CX[subscript 14]CX[subscript 2]C.United States. Dept. of Energy. Office of Biological and Environmental ResearchUnited States. Dept. of Energy. Office of Basic Energy SciencesNational Center for Research Resources (U.S.) (P41RR012408)National Institute of General Medical Sciences (U.S.) (P41GM103473)National Center for Research Resources (U.S.) (5P41RR015301-10)National Institute of General Medical Sciences (U.S.) (8 P41 GM 103403-10)United States. Dept. of Energy (Contract DE-AC02-06CH11357

Invasive alien aquatic plants in South African freshwater ecosystems

FWN – Publicaties zonder aanstelling Universiteit Leide

Teaching music with mathematics : a pilot study

We detail a recently conducted teaching intervention involving the use of mathematics and associated software to teach rhythm and meter to Year 9 pupils. This intervention served as a feasibility and pilot study within a broader project related to the mutual teaching of mathematics and music. Causal conclusions cannot be made due to the lack of a control group, but questionnaires show that 81% of the pupils found interacting with software helped them to understand and visualize mathematical theories of rhythm and meter, and the same percentage think that mathematics and music are related. The two teachers who delivered the program enjoyed the experience and felt the software was beneficial