18 research outputs found

    Comb-Based Radio-Frequency Photonic Filters with Rapid Tunability and High Selectivity

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    Photonic technologies have received considerable attention for enhancement of radio-frequency (RF) electrical systems, including high-frequency analog signal transmission, control of phased arrays, analog-to-digital conversion, and signal processing. Although the potential of radio-frequency photonics for implementation of tunable electrical filters over broad RF bandwidths has been much discussed, realization of programmable filters with highly selective filter lineshapes and rapid reconfigurability has faced significant challenges. A new approach for RF photonic filters based on frequency combs offers a potential route to simultaneous high stopband attenuation, fast tunability, and bandwidth reconfiguration. In one configuration tuning of the RF passband frequency is demonstrated with unprecedented (~40 ns) speed by controlling the optical delay between combs. In a second, fixed filter configuration, cascaded four-wave mixing simultaneously broadens and smoothes comb spectra, resulting in Gaussian RF filter lineshapes exhibiting extremely high (>60 dB) main lobe to sidelobe suppression ratio and (>70 dB) stopband attenuation.Comment: Updated the submission with the most recent version of the pape

    An endogenous nanomineral chaperones luminal antigen and peptidoglycan to intestinal immune cells.

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    In humans and other mammals it is known that calcium and phosphate ions are secreted from the distal small intestine into the lumen. However, why this secretion occurs is unclear. Here, we show that the process leads to the formation of amorphous magnesium-substituted calcium phosphate nanoparticles that trap soluble macromolecules, such as bacterial peptidoglycan and orally fed protein antigens, in the lumen and transport them to immune cells of the intestinal tissue. The macromolecule-containing nanoparticles utilize epithelial M cells to enter Peyer's patches, small areas of the intestine concentrated with particle-scavenging immune cells. In wild-type mice, intestinal immune cells containing these naturally formed nanoparticles expressed the immune tolerance-associated molecule 'programmed death-ligand 1', whereas in NOD1/2 double knockout mice, which cannot recognize peptidoglycan, programmed death-ligand 1 was undetected. Our results explain a role for constitutively formed calcium phosphate nanoparticles in the gut lumen and show how this helps to shape intestinal immune homeostasis

    Ebola virus disease and critical illness

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    Characterization and modeling of microstructured chalcogenide fibers for efficient mid-infrared wavelength conversion

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    We experimentally demonstrate wavelength conversion in the 2 micron region by four-wave mixing in an AsSe and a GeAsSe chalcogenide photonic crystal fibers. A maximum conversion efficiency of -25.4 dB is measured for 112 mW of coupled continuous wave pump in a 27 cm long fiber. We estimate the dispersion parameters and the nonlinear refractive indexes of the chalcogenide PCFs, establishing a good agreement with the values expected from simulations. The different fiber geometries and glass compositions are compared in terms of performance, showing that GeAsSe is a more suited candidate for nonlinear optics at 2 micron. Building from the fitted parameters we then propose a new tapered GeAsSe PCF geometry to tailor the waveguide dispersion and lower the zero dispersion wavelength (ZDW) closer to the 2 mu m pump wavelength. Numerical simulations shows that the new design allows both an increased conversion efficiency and bandwidth, and the generation of idler waves further in the mid-IR regions, by tuning the pump wavelength in the vicinity of the fiber ZDW

    Recent Advances on Nonlinear Optics in Silicon Nitride Waveguides

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    Nonlinear phenomena based on the material 2nd or 3rd order nonlinear susceptibility tensor χ(2) and χ(3), respectively, offer potential in a wide variety of applications by exploiting wave-mixing capabilities. The integration of these nonlinear effects at the chip scale represents the best path towards portable, compact and low power optical signal processing devices. A significant body of work has been done recently in this direction, in particular focusing on CMOS-compatible platforms. While many nonlinear effects have been demonstrated in Silicon, Silicon Nitride has recently sparked significant interest. Owing to a larger band gap, wide transparency window and low loss, the potential of SiN waveguides for linear and nonlinear optics is now well established. In this paper, we report recent results on nonlinear processes in SiN waveguides. In particular we will cover generation of an extremely broad supercontinuum extending 400 THz from the visible to 3.6 µm pumped by a turnkey telecom wavelength pulsed source. We will also report on a tunable pulse source based on dispersive wave generation in an engineered thick waveguide. Finally, we will show that SiN offers some interesting potential for χ(2) based nonlinear effects, an important step towards integrating second order nonlinearity on chip

    Mid infrared gas spectroscopy using efficient fiber laser driven photonic chip-based supercontinuum

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    Directly accessing the middle infrared, the molecular functional group spectral region, via supercontinuum generation processes based on turn-key fiber lasers offers the undeniable advantage of simplicity and robustness. Recently, the assessment of the coherence of the mid-IR dispersive wave in silicon nitride (Si3N4) waveguides, pumped at telecom wavelength, established an important first step towards mid-IR frequency comb generation based on such compact systems. Yet, the spectral reach and efficiency still fall short for practical implementation. Here, we experimentally demonstrate that large cross-section Si3N4 waveguides pumped with 2 mu m fs-fiber laser can reach the important spectroscopic spectral region in the 3-4 mu m range, with up to 35% power conversion and milliwatt-level output powers. As a proof of principle, we use this source for detection of C2H2 by absorption spectroscopy. Such result makes these sources suitable candidate for compact, chip-integrated spectroscopic and sensing applications

    Mid-infrared frequency comb via coherent dispersive wave generation in silicon nitride nanophotonic waveguides

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    Mid-infrared optical frequency combs are of significant interest for molecular spectroscopy due to the large absorption of molecular vibrational modes on the one hand, and the ability to implement superior comb-based spectroscopic modalities with increased speed, sensitivity and precision on the other hand. Here, we demonstrate a simple, yet effective, method for the direct generation of mid-infrared optical frequency combs in the region from 2.5 to 4.0 mu m (that is, 2,500-4,000 cm(-1)), covering a large fraction of the functional group region, from a conventional and compact erbium-fibre-based femtosecond laser in the telecommunication band (that is, 1.55 mu m). The wavelength conversion is based on dispersive wave generation within the supercontinuum process in an unprecedented large-cross-section silicon nitride (Si3N4) waveguide with the dispersion lithographically engineered. The long-wavelength dispersive wave can perform as a mid-infrared frequency comb, whose coherence is demonstrated via optical heterodyne measurements. Such an approach can be considered as an alternative option to mid-infrared frequency comb generation. Moreover, it has the potential to realize compact dual-comb spectrometers. The generated combs also have a fine teeth-spacing, making them suitable for gas-phase analysis
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