Spontaneous Isotropy Breaking: A Mechanism for CMB Multipole Alignments

We introduce a class of models in which statistical isotropy is broken spontaneously in the CMB by a non-linear response to long-wavelength fluctuations in a mediating field. These fluctuations appear as a gradient locally and pick out a single preferred direction. The non-linear response imprints this direction in a range of multipole moments. We consider two manifestations of isotropy breaking: additive contributions and multiplicative modulation of the intrinsic anisotropy. Since WMAP exhibits an alignment of power deficits, an additive contribution is less likely to produce the observed alignments than the usual isotropic fluctuations, a fact which we illustrate with an explicit cosmological model of long-wavelength quintessence fluctuations. This problem applies to other models involving foregrounds or background anisotropy that seek to restore power to the CMB. Additive models that account directly for the observed power exacerbate the low power of the intrinsic fluctuations. Multiplicative models can overcome these difficulties. We construct a proof of principle model that significantly improves the likelihood and generates stronger alignments than WMAP in 30-45% of realizations.Comment: 13 pages, 10 figure

Transforming the Knowledge Gap for Local Planning Officials: Impacts of Continuing Education in a Master Citizen Planner Program

In an era of increasing complexity, the majority of local land-use decisions in the United States are made by volunteer citizen planners. Often these elected or appointed volunteers enter their positions with a passion for their communities but without appropriate background training. The Michigan Citizen Planner Program was developed to address this gap. The study described in this article investigated the self-assessed impacts on graduates of basic and advanced training. Findings suggest that training conducted as the result of collaboration by university Extension, other state agencies, and nonprofit groups is essential to realizing the positive community development impacts expected by citizens and local officials

Comparison of Chinese and U.S. Patent Reform Legislation: Which, If Either, Got it Right?, 11 J. Marshall Rev. Intell. Prop. L. 567 (2012)

Chinese patent law has a short history whereas the United States ( U.S. ) system has a more robust history. This article chronicles important remaining differences between Chinese and U.S. patent laws including the utility model successfully employed at State Intellectual Property Office of the People’s Republic of China ( SIPO ) and in the Chinese courts, but not available under U.S. law. Some differences are discussed in regard of patent appeals, reexaminations for invalidity, China’s lack of a reissue process to correct major errors, China’s inventors remuneration process and compulsory licensing of patents, and China’s unique requirement of post termination compensation to support a covenant not to compete. This article further discusses recent changes in U.S. Patent law, as a result of the American Invents Act, that have no counterpart in China. This includes a discussion on changes in the rules governing when prior art applies against applications, new misjoinder rules and elimination of qui tam patent suits rules. This article discusses the new procedure in the United States Patent and Trademark Office ( USPTO ) called post grant review and a companion process for review of validity of granted patents called inter partes review. These new proceedings have the potential for invalidation of patents in a manner far less expensive than in court. However, the devil will be in the details of the regulations and fees yet to be promulgated by the USPTO or reviewed by the public. Whether China or the United States got it right is too early to tell and is anyone’s guess

Impact of Poor Retention in HIV Medical Care on Time to Viral Load Suppression

Objective: The purpose of this study was to evaluate how poor retention in HIV care impacts time to viral suppression after initiating highly active antiretroviral therapy. Methods: A retrospective cohort study design, employing a medical chart review, was conducted at an academic infectious disease clinic at the University of Kentucky. Patients seeking care between 2003 and 2011 were included in the study. A log-normal model was employed to determine the factors associated with time to viral suppression. Results: Of the 532 patients in the study, 426 (80.1%) patients were virally suppressed. Controlling for insurance status, race, baseline CD4 counts, and viral loads, the expected time to viral suppression for nonoptimal retainers was longer compared to optimal retainers (100% retained in care; time ratio: 2.04; 95% confidence interval: 1.40-2.90). Conclusion: Researchers should continue to study the impact of retention on clinical outcomes and strategies to improve retention and reengage those lost to follow-up back into care. © The Author(s) 2013

Neuromuscular Performance in a Kansas Mennonite Community: Age and Sex Effects in Performance

This is the published version. Copyright 1985 Wayne State University Press.The effects of age and sex on six neuromuscular performance traits are studied in a cross-sectional sample of 559 members of the Goessel, Kansas Mennonite community. Age and sex effects are assessed by stepwise polynomial regression which includes non-linear age terms up to the fourth power. Of the six traits studied only one, Hand Steadiness, fails to show a significant sex difference and only one, Trunk Flexibility, fails to show a significant non-linear trend with age. A general pattern, seen in these traits of accelerating performance decline after age 45 of up to 60%, is found to be consistent with that reported in other studies of the same traits. The consistency of this non-linear aging pattern suggests the presence of a general neuromuscular aging process. Moreover, this process appears likely to be related to a two-stage mechanism inferred from both animal and human studies involving a decline in protein synthesis and a loss of cell mass in nerve and muscle tissue

Work-life Events Theory: Making Sense of Shock Events in Dual-Earner Couples

Dual-earner couples are increasingly prevalent and encounter demands arising from each partner’s commitment to various work and life domains. Unfortunately, there has been little theoretical progress in explaining how dual-earner couples navigate work-life shock events, which we define as disruptive, novel, and critical events that require investment of a couple’s resources. Drawing from identity and sensemaking theories, we develop a theory of work-life shock events to explain how dual-earner couples perceive and respond to these events. We theorize that partners initially make sense of the event as individuals and then engage in couple-level sensemaking. We argue that each individual’s shock intensity perceptions are shaped by the shock event’s characteristics and the identity factors of role salience hierarchy and future self. A subsequent couple-level process of sensemaking ensues, influenced by the salience of the originating domain and partner role, as well as relational identity factors. Couple-level shock intensity perceptions result in the couple’s decision regarding resource investment in the shock event’s originating domain. We discuss implications for future research and for organizations

A systematic review of the quality of homeopathic clinical trials

BACKGROUND: While a number of reviews of homeopathic clinical trials have been done, all have used methods dependent on allopathic diagnostic classifications foreign to homeopathic practice. In addition, no review has used established and validated quality criteria allowing direct comparison of the allopathic and homeopathic literature. METHODS: In a systematic review, we compared the quality of clinical-trial research in homeopathy to a sample of research on conventional therapies using a validated and system-neutral approach. All clinical trials on homeopathic treatments with parallel treatment groups published between 1945–1995 in English were selected. All were evaluated with an established set of 33 validity criteria previously validated on a broad range of health interventions across differing medical systems. Criteria covered statistical conclusion, internal, construct and external validity. Reliability of criteria application is greater than 0.95. RESULTS: 59 studies met the inclusion criteria. Of these, 79% were from peer-reviewed journals, 29% used a placebo control, 51% used random assignment, and 86% failed to consider potentially confounding variables. The main validity problems were in measurement where 96% did not report the proportion of subjects screened, and 64% did not report attrition rate. 17% of subjects dropped out in studies where this was reported. There was practically no replication of or overlap in the conditions studied and most studies were relatively small and done at a single-site. Compared to research on conventional therapies the overall quality of studies in homeopathy was worse and only slightly improved in more recent years. CONCLUSIONS: Clinical homeopathic research is clearly in its infancy with most studies using poor sampling and measurement techniques, few subjects, single sites and no replication. Many of these problems are correctable even within a "holistic" paradigm given sufficient research expertise, support and methods

A Multi-Functional View of Moral Disengagement: Exploring the Effects of Learning the Consequences

This paper takes us beyond the unethical act and explores the use of moral disengagement as a multi-stage, multi-functional regulatory, and coping mechanism that not only allows individuals to engage in unethical behavior, but also manage the negative emotions (i.e., guilt and shame) from learning the consequences of such behavior. A resource-based lens is applied to the moral disengagement process, suggesting that individuals not only morally disengage prior to committing an unethical act in order to conserve their own resources, but also morally disengage as a coping mechanism to reduce emotional duress upon learning of the consequences of their actions, which we describe as post-moral disengagement. These assertions are tested using a scenario-based laboratory study consisting of 182 respondents. Findings indicate that individuals will morally disengage in order to commit an unethical act, will experience negative emotions from having learned of the consequences, and then will engage in post-moral disengagement as a coping mechanism. In addition, the findings suggest that guilt and shame relate differently to moral disengagement