Induction of autophagy by spermidine promotes longevity.

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Technology-assisted training of arm-hand skills in stroke: concepts on reacquisition of motor control and therapist guidelines for rehabilitation technology design

<p>Abstract</p> <p>Background</p> <p>It is the purpose of this article to identify and review criteria that rehabilitation technology should meet in order to offer arm-hand training to stroke patients, based on recent principles of motor learning.</p> <p>Methods</p> <p>A literature search was conducted in PubMed, MEDLINE, CINAHL, and EMBASE (1997–2007).</p> <p>Results</p> <p>One hundred and eighty seven scientific papers/book references were identified as being relevant. Rehabilitation approaches for upper limb training after stroke show to have shifted in the last decade from being analytical towards being focussed on environmentally contextual skill training (task-oriented training). Training programmes for enhancing motor skills use patient and goal-tailored exercise schedules and individual feedback on exercise performance. Therapist criteria for upper limb rehabilitation technology are suggested which are used to evaluate the strengths and weaknesses of a number of current technological systems.</p> <p>Conclusion</p> <p>This review shows that technology for supporting upper limb training after stroke needs to align with the evolution in rehabilitation training approaches of the last decade. A major challenge for related technological developments is to provide engaging patient-tailored task oriented arm-hand training in natural environments with patient-tailored feedback to support (re) learning of motor skills.</p

Mutual interferences and design principles for mechatronic devices in magnetic resonance imaging

PURPOSE: Robotic and mechatronic devices that work compatibly with magnetic resonance imaging (MRI) are applied in diagnostic MRI, image-guided surgery, neurorehabilitation and neuroscience. MRI-compatible mechatronic systems must address the challenges imposed by the scanner's electromagnetic fields. We have developed objective quantitative evaluation criteria for device characteristics needed to formulate design guidelines that ensure MRI-compatibility based on safety, device functionality and image quality. METHODS: The mutual interferences between an MRI system and mechatronic devices working in its vicinity are modeled and tested. For each interference, the involved components are listed, and a numerical measure for "MRI-compatibility" is proposed. These interferences are categorized into an MRI-compatibility matrix, with each element representing possible interactions between one part of the mechatronic system and one component of the electromagnetic fields. Based on this formulation, design principles for MRI-compatible mechatronic systems are proposed. Furthermore, test methods are developed to examine whether a mechatronic device indeed works without interferences within an MRI system. Finally, the proposed MRI-compatibility criteria and design guidelines have been applied to an actual design process that has been validated by the test procedures. RESULTS: Objective and quantitative MRI-compatibility measures for mechatronic and robotic devices have been established. Applying the proposed design principles, potential problems in safety, device functionality and image quality can be considered in the design phase to ensure that the mechatronic system will fulfill the MRI-compatibility criteria. CONCLUSION: New guidelines and test procedures for MRI instrument compatibility provide a rational basis for design and evaluation of mechatronic devices in various MRI applications. Designers can apply these criteria and use the tests, so that MRI-compatibility results can accrue to build an experiential database

Functional effects of ankle sprain

Ankle sprain is one of the most common sports-related injuries and can lead to recurrences and chronic ankle instability (CAI). In the acute phase, ankle sprain patients experience mostly pain, limited ankle mobility, and reduced ankle muscle strength. CAI patients have a history of their ankle “giving way” and/or “feeling unstable,” after at least one significant ankle sprain. They continue to suffer from pain and impaired performance during functional tasks. Both acute ankle sprains and CAI have a negative influence on daily life activities such as walking, sports-related activities such as jump landings, as well as on patients’ perception of health and function. Functional deficits should be carefully assessed for appropriate clinical decision making and to propose the most suitable, individualized (physiotherapeutic) intervention. Acute ankle sprains are first treated according to the rest, ice, compression, and elevation (RICE) protocol. Nonsteroidal anti-inflammatory drugs may also be recommended for pain management. A short period of immobilization by means of a lower leg cast can facilitate rapid decrease in pain and swelling. Afterward, functional exercise therapy is recommended. In the case of CAI, patients should wear external ankle support during sporting activities to reduce the risk of recurring sprains and undergo exercise therapy including balance and muscle strengthening exercises. New technologies could be implemented in future rehabilitation programs in order to offer athletes greater flexibility in terms of training time and more varied, sports-related, exercises at home