468 research outputs found
Spectrum from the warped compactifications with the de Sitter universe
We discuss the spectrum of the tensor metric perturbations and the stability
of warped compactifications with the de Sitter spacetime in the
higher-dimensional gravity. The spacetime structure is given in terms of the
warped product of the non-compact direction, the spherical internal dimensions
and the four-dimensional de Sitter spacetime. To realize a finite bulk volume,
we construct the brane world model, using the cut-copy-paste method. Then, we
compactify the spherical directions on the brane. In any case, we show the
existence of the massless zero mode and the mass gap of it with massive
Kaluza-Klein modes. Although the brane involves the spherical dimensions, no
light massive mode is excited. We also investigate the scalar perturbations,
and show that the model is unstable due to the existence of a tachyonic bound
state, which seems to have the universal negative mass square, irrespective of
the number of spacetime dimensions.Comment: Journal version (JHEP
Differential electrographic signatures generated by mechanistically-diverse seizurogenic compounds in the larval zebrafish brain.
This is the final version. Available from the Society for Neuroscience via the DOI in this record. We assessed similarities and differences in the electrographic signatures of local field potentials (LFPs) evoked by different pharmacological agents in zebrafish larvae. We then compared and contrasted these characteristics with what is known from electrophysiological studies of seizures and epilepsy in mammals, including humans. Ultimately, our aim was to phenotype neurophysiological features of drug-induced seizures in larval zebrafish for expanding knowledge on the translational potential of this valuable alternative to mammalian models. LFPs were recorded from the midbrain of 4-d-old zebrafish larvae exposed to a pharmacologically diverse panel of seizurogenic compounds, and the outputs of these recordings were assessed using frequency domain analysis. This included analysis of changes occurring within various spectral frequency bands of relevance to mammalian CNS circuit pathophysiology. From these analyses, there were clear differences in the frequency spectra of drug-exposed LFPs, relative to controls, many of which shared notable similarities with the signatures exhibited by mammalian CNS circuits. These similarities included the presence of specific frequency components comparable to those observed in mammalian studies of seizures and epilepsy. Collectively, the data presented provide important information to support the value of larval zebrafish as an alternative model for the study of seizures and epilepsy. These data also provide further insight into the electrophysiological characteristics of seizures generated in nonmammalian species by the action of neuroactive drugs.National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs
Nitrogen and phosphorus availability interact to modulate leaf trait scaling relationships across six plant functional types in a controlled-environment study
Nitrogen (N) and phosphorus (P) have key roles in leaf metabolism, resulting in a strong coupling of chemical composition traits to metabolic rates in field-based studies. However, in such studies, it is difficult to disentangle the effects of nutrient supply per se on trait-trait relationships. Our study assessed how high and low N (5 mM and 0.4 mM, respectively) and P (1 mM and 2 μM, respectively) supply in 37 species from six plant functional types (PTFs) affected photosynthesis (A) and respiration (R) (in darkness and light) in a controlled environment. Low P supply increased scaling exponents (slopes) of area-based log-log A-N or R-N relationships when N supply was not limiting, whereas there was no P effect under low N supply. By contrast, scaling exponents of A-P and R-P relationships were altered by P and N supply. Neither R : A nor light inhibition of leaf R was affected by nutrient supply. Light inhibition was 26% across nutrient treatments; herbaceous species exhibited a lower degree of light inhibition than woody species. Because N and P supply modulates leaf trait-trait relationships, the next generation of terrestrial biosphere models may need to consider how limitations in N and P availability affect trait-trait relationships when predicting carbon exchange
Patterns of Soft Masses from General Semi-Direct Gauge Mediation
We give a general formulation of semi-direct gauge mediation of supersymmetry
breaking where the messengers interact with the hidden sector only through a
weakly gauged group. Using this general formulation, we provide an explicit
proof that the MSSM gaugino masses are vanishing to leading order in the gauge
couplings. On the other hand, the MSSM sfermion masses have, generically, a
non-vanishing leading contribution. We discuss how such a mechanism can
successfully be combined with other mediation schemes which give tachyonic
sfermions, such as sequestered anomaly mediation and some direct gauge
mediation models.Comment: 26 pages, 5 figures; v2: refs added; v3: minor corrections,
clarifications added, mainly in section
4-dimensional functional profiling in the convulsant-treated larval zebrafish brain
This is the final version of the article. Available from Springer Nature via the DOI in this record.Functional neuroimaging, using genetically-encoded Ca(2+) sensors in larval zebrafish, offers a powerful combination of high spatiotemporal resolution and higher vertebrate relevance for quantitative neuropharmacological profiling. Here we use zebrafish larvae with pan-neuronal expression of GCaMP6s, combined with light sheet microscopy and a novel image processing pipeline, for the 4D profiling of chemoconvulsant action in multiple brain regions. In untreated larvae, regions associated with autonomic functionality, sensory processing and stress-responsiveness, consistently exhibited elevated spontaneous activity. The application of drugs targeting different convulsant mechanisms (4-Aminopyridine, Pentylenetetrazole, Pilocarpine and Strychnine) resulted in distinct spatiotemporal patterns of activity. These activity patterns showed some interesting parallels with what is known of the distribution of their respective molecular targets, but crucially also revealed system-wide neural circuit responses to stimulation or suppression. Drug concentration-response curves of neural activity were identified in a number of anatomically-defined zebrafish brain regions, and in vivo larval electrophysiology, also conducted in 4dpf larvae, provided additional measures of neural activity. Our quantification of network-wide chemoconvulsant drug activity in the whole zebrafish brain illustrates the power of this approach for neuropharmacological profiling in applications ranging from accelerating studies of drug safety and efficacy, to identifying pharmacologically-altered networks in zebrafish models of human neurological disorders.This work was funded by the Biological and Biotechnology Research Council (CASE studentship BB/L502510/1, with AstraZeneca Safety Health and Environment), and by the University of Exeter and AstraZeneca
Total-Hg and organic-Hg in Cephalopholis fulva (Linnaeus, 1758) from inshore and offshore waters of NE Brazil
(Extra)Ordinary Gauge/Anomaly Mediation
We study anomaly mediation models with gauge mediation effects from
messengers which have a general renormalizable mass matrix with a
supersymmetry-breaking spurion. Our models lead to a rich structure of
supersymmetry breaking terms in the visible sector. We derive sum rules among
the soft scalar masses for each generation. Our sum rules for the first and
second generations are the same as those in general gauge mediation, but the
sum rule for the third generation is different because of the top Yukawa
coupling. We find the parameter space where the tachyonic slepton problem is
solved. We also explore the case in which gauge mediation causes the
anomalously small gaugino masses. Since anomaly mediation effects on the
gaugino masses exist, we can obtain viable mass spectrum of the visible sector
fields.Comment: 24 pages, 10 figure
General Messenger Gauge Mediation
We discuss theories of gauge mediation in which the hidden sector consists of
two subsectors which are weakly coupled to each other. One sector is made up of
messengers and the other breaks supersymmetry. Each sector by itself may be
strongly coupled. We provide a unifying framework for such theories and discuss
their predictions in different settings. We show how this framework
incorporates all known models of messengers. In the case of weakly-coupled
messengers interacting with spurions through the superpotential, we prove that
the sfermion mass-squared is positive, and furthermore, that there is a lower
bound on the ratio of the sfermion mass to the gaugino mass.Comment: 37 pages; minor change
A low density of 0.8 g/cc for the Trojan binary asteroid 617 Patroclus
The Trojan population consists of two swarms of asteroids following the same
orbit as Jupiter and located at the L4 and L5 Lagrange points of the
Jupiter-Sun system (leading and following Jupiter by 60 degrees). The asteroid
617 Patroclus is the only known binary Trojan (Merline et al. 2001). The orbit
of this double system was hitherto unknown. Here we report that the components,
separated by 680 km, move around the system centre of mass, describing roughly
a circular orbit. Using the orbital parameters, combined with thermal
measurements to estimate the size of the components, we derive a very low
density of 0.8 g/cc. The components of Patroclus are therefore very porous or
composed mostly of water ice, suggesting that they could have been formed in
the outer part of the solar system.Comment: 10 pages, 3 figures, 1 tabl
Simplified R-Symmetry Breaking and Low-Scale Gauge Mediation
We argue that some of the difficulties in constructing realistic models of
low-scale gauge mediation are artifacts of the narrow set of models that have
been studied. In particular, much attention has been payed to the scenario in
which the Goldstino superfield in an O'Raifeartaigh model is responsible for
both supersymmetry breaking and R-symmetry breaking. In such models, the
competing problems of generating sufficiently massive gauginos while preserving
an acceptably light gravitino can be quite challenging. We show that by sharing
the burdens of breaking supersymmetry and R-symmetry with a second field, these
problems are easily solved even within the O'Raifeartaigh framework. We present
explicit models realizing minimal gauge mediation with a gravitino mass in the
eV range that are both calculable and falsifiable.Comment: 31 pages, 4 figures, references added, minor change
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