378 research outputs found
Supersymmetric Extension of GCA in 2d
We derive the infinite dimensional Supersymmetric Galilean Conformal Algebra
(SGCA) in the case of two spacetime dimensions by performing group contraction
on 2d superconformal algebra. We also obtain the representations of the
generators in terms of superspace coordinates. Here we find realisations of the
SGCA by considering scaling limits of certain 2d SCFTs which are non-unitary
and have their left and right central charges become large in magnitude and
opposite in sign. We focus on the Neveu-Schwarz sector of the parent SCFTs and
develop, in parallel to the GCA studies recently in (arXiv:0912.1090), the
representation theory based on SGCA primaries, Ward identities for their
correlation functions and their descendants which are null states.Comment: La TeX file, 32 pages; v2: typos corrected, journal versio
GCA in 2d
We make a detailed study of the infinite dimensional Galilean Conformal
Algebra (GCA) in the case of two spacetime dimensions. Classically, this
algebra is precisely obtained from a contraction of the generators of the
relativistic conformal symmetry in 2d. Here we find quantum mechanical
realisations of the (centrally extended) GCA by considering scaling limits of
certain 2d CFTs. These parent CFTs are non-unitary and have their left and
right central charges become large in magnitude and opposite in sign. We
therefore develop, in parallel to the usual machinery for 2d CFT, many of the
tools for the analysis of the quantum mechanical GCA. These include the
representation theory based on GCA primaries, Ward identities for their
correlation functions and a nonrelativistic Kac table. In particular, the null
vectors of the GCA lead to differential equations for the four point function.
The solution to these equations in the simplest case is explicitly obtained and
checked to be consistent with various requirements.Comment: 45 pages; v2: 47 pages. Restructured introduction, minor corrections,
added references. Journal versio
Realization of a Tunable Artificial Atom at a Supercritically Charged Vacancy in Graphene
The remarkable electronic properties of graphene have fueled the vision of a
graphene-based platform for lighter, faster and smarter electronics and
computing applications. One of the challenges is to devise ways to tailor its
electronic properties and to control its charge carriers. Here we show that a
single atom vacancy in graphene can stably host a local charge and that this
charge can be gradually built up by applying voltage pulses with the tip of a
scanning tunneling microscope (STM). The response of the conduction electrons
in graphene to the local charge is monitored with scanning tunneling and Landau
level spectroscopy, and compared to numerical simulations. As the charge is
increased, its interaction with the conduction electrons undergoes a transition
into a supercritical regime 6-11 where itinerant electrons are trapped in a
sequence of quasi-bound states which resemble an artificial atom. The
quasi-bound electron states are detected by a strong enhancement of the density
of states (DOS) within a disc centered on the vacancy site which is surrounded
by halo of hole states. We further show that the quasi-bound states at the
vacancy site are gate tunable and that the trapping mechanism can be turned on
and off, providing a new mechanism to control and guide electrons in grapheneComment: 18 pages and 5 figures plus 14 pages and 15 figures of supplementary
information. Nature Physics advance online publication, Feb 22 (2016
Universal time-dependent deformations of Schrodinger geometry
We investigate universal time-dependent exact deformations of Schrodinger
geometry. We present 1) scale invariant but non-conformal deformation, 2)
non-conformal but scale invariant deformation, and 3) both scale and conformal
invariant deformation. All these solutions are universal in the sense that we
could embed them in any supergravity constructions of the Schrodinger invariant
geometry. We give a field theory interpretation of our time-dependent
solutions. In particular, we argue that any time-dependent chemical potential
can be treated exactly in our gravity dual approach.Comment: 24 pages, v2: references adde
Charged, conformal non-relativistic hydrodynamics
We embed a holographic model of an U(1) charged fluid with Galilean
invariance in string theory and calculate its specific heat capacity and
Prandtl number. Such theories are generated by a R-symmetry twist along a null
direction of a N=1 superconformal theory. We study the hydrodynamic properties
of such systems employing ideas from the fluid-gravity correspondence.Comment: 31 pages, 1 figure, JHEP3 style, refs added, typos corrected, missing
terms in spatial charge current and field corrections added, to be published
in JHE
Adolescent Self-Organization and Adult Smoking and Drinking over Fifty Years of Follow-Up:The British 1946 Birth Cohort
Variations in markers of adolescent self-organization predict a range of economic and health-related outcomes in general population studies. Using a population-based birth cohort study we investigated associations between adolescent self-organization and two common factors over adulthood influencing health, smoking and alcohol consumption. The MRC National Survey of Health and Development (the British 1946 birth cohort) was used to test associations between a dimensional measure of adolescent self-organization derived from teacher ratings, and summary longitudinal measures of smoking and alcohol consumption over the ensuing five decades. Multinomial regression models were adjusted for sex, adolescent emotional and conduct problems, occupational social class of origin, childhood cognition, educational attainment and adult occupational social class. With all covariates adjusted, higher adolescent self-organization was associated with fewer smoking pack years, although not with quitting; there was no association with alcohol consumption across adulthood (none or heavy compared with light to moderate). Adolescent self-organization appears to be protective against smoking, but not against heavy alcohol consumption. Interpretation of this differential effect should be embedded in an understanding of the social and sociodemographic context in which these health behaviours occur over time
Co expression of SCF and KIT in gastrointestinal stromal tumours (GISTs) suggests an autocrine/paracrine mechanism
KIT is a tyrosine kinase receptor expressed by several tumours, which has for specific ligand the stem cell factor (SCF). KIT is the main oncogene in gastrointestinal stromal tumours (GISTs), and gain-of-function KIT mutations are present in 70% of these tumours. The aim of the study was to measure and investigate the mechanisms of KIT activation in 80 KIT-positive GIST patients. KIT activation was quantified by detecting phosphotyrosine residues in Western blotting. SCF production was determined by reverse transcriptase–PCR, ELISA and/or immunohistochemistry. Primary cultures established from three GISTs were also analysed. The results show that KIT activation was detected in all cases, even in absence of KIT mutations. The fraction of activated KIT was not correlated with the mutational status of GISTs. Membrane and soluble isoforms of SCF mRNA were present in all GISTs analysed. Additionally, SCF was also detected in up to 93% of GISTs, and seen to be present within GIST cells. Likewise, the two SCF mRNA isoforms were found to be expressed in GIST-derived primary cultures. Thus, KIT activation in GISTs may in part result from the presence of SCF within the tumours
Shadoo (Sprn) and prion disease incubation time in mice
Prion diseases are transmissible neurodegenerative disorders of mammalian species and include scrapie, bovine spongiform encephalopathy (BSE), and variant Creutzfeldt-Jakob disease (vCJD). The prion protein (PrP) plays a key role in the disease, with coding polymorphism in both human and mouse influencing disease susceptibility and incubation time, respectively. Other genes are also thought to be important and a plausible candidate is Sprn, which encodes the PrP-like protein Shadoo (Sho). Sho is expressed in the adult central nervous system and exhibits neuroprotective activity reminiscent of PrP in an in vitro assay. To investigate the role of Sprn in prion disease incubation time we sequenced the open reading frame (ORF) in a diverse panel of mice and saw little variation except in strains derived from wild-trapped mice. Sequencing the untranslated regions revealed polymorphisms that allowed us to carry out an association study of incubation period in the Northport heterogeneous stock of mice inoculated with Chandler/RML prions. We also examined the expression level of Sprn mRNA in the brains of normal and prion-infected mice and saw no correlation with either genotype or incubation time. We therefore conclude that Sprn does not play a major role in prion disease incubation time in these strains of mice
Cyr61/CCN1 Displays High-Affinity Binding to the Somatomedin B 1–44 Domain of Vitronectin
OV) family of extracellular-associated (matricellular) proteins that present four distinct functional modules, namely insulin-like growth factor binding protein (IGFBP), von Willebrand factor type C (vWF), thrombospondin type 1 (TSP), and C-terminal growth factor cysteine knot (CT) domain. While heparin sulphate proteoglycans reportedly mediate the interaction of Cyr61 with the matrix and cell surface, the role of other extracellular associated proteins has not been revealed. at high concentrations attenuate Cyr61 binding to immobilized VTNC, while monomeric VTNC was ineffective. Therefore, immobilization of VTNC exposes cryptic epitopes that recognize Cyr61 with high affinity, as reported for a number of antibodies, β-endorphin, and other molecules. domain suggests that VTNC represent a point of anchorage for CCN family members to the matrix. Results are discussed in the context of the role of CCN and VTNC in matrix biology and angiogenesis
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