The Role of the Brain in the Pathogenesis and Physiology of Polycystic Ovary Syndrome (PCOS).

Polycystic ovary syndrome (PCOS) is a common reproductive endocrine disorder, affecting at least 10% of women of reproductive age. PCOS is typically characterized by the presence of at least two of the three cardinal features of hyperandrogenemia (high circulating androgen levels), oligo- or anovulation, and cystic ovaries. Hyperandrogenemia increases the severity of the condition and is driven by increased luteinizing hormone (LH) pulse secretion from the pituitary. Indeed, PCOS women display both elevated mean LH levels, as well as an elevated frequency of LH pulsatile secretion. The abnormally high LH pulse frequency, reflective of a hyperactive gonadotropin-releasing hormone (GnRH) neural circuit, suggests a neuroendocrine basis to either the etiology or phenotype of PCOS. Several studies in preclinical animal models of PCOS have demonstrated alterations in GnRH neurons and their upstream afferent neuronal circuits. Some rodent PCOS models have demonstrated an increase in GnRH neuron activity that correlates with an increase in stimulatory GABAergic innervation and postsynaptic currents onto GnRH neurons. Additional studies have identified robust increases in hypothalamic levels of kisspeptin, another potent stimulator of GnRH neurons. This review outlines the different brain and neuroendocrine changes in the reproductive axis observed in PCOS animal models, discusses how they might contribute to either the etiology or adult phenotype of PCOS, and considers parallel findings in PCOS women

An efficient prescription to find the eigenfunctions of point interactions Hamiltonians

A prescription invented a long time ago by Case and Danilov is used to get the wave function of point interactions in two and three dimensions.Comment: 6 page

Bounds on Z′Z^\prime from 3-3-1 model at the LHC energies

The Large Hadron Collider will restart with higher energy and luminosity in 2015. This achievement opens the possibility of discovering new phenomena hardly described by the Standard Model, that is based on two neutral gauge bosons: the photon and the $Z$. This perspective imposes a deep and systematic study of models that predicts the existence of new neutral gauge bosons. One of such models is based on the gauge group $SU(3)_C \times SU(3)_L \times U(1)_N$ called 3-3-1 model for short. In this paper we perform a study with $Z^\prime$ predicted in two versions of the 3-3-1 model and compare the signature of this resonance in each model version. By considering the present and future LHC energy regimes, we obtain some distributions and the total cross section for the process $p + p \longrightarrow \ell^{+} + \ell^{-} + X$. Additionally, we derive lower bounds on $Z^\prime$ mass from the latest LHC results. Finally we analyze the LHC potential for discovering this neutral gauge boson at 14 TeV center-of-mass energy.Comment: 6 pages, 9 figures, 2 table

Dirac's hole theory versus quantum field theory

Dirac's hole theory and quantum field theory are usually considered equivalent to each other. For models of a certain type, however, the equivalence may not hold as we discuss in this Letter. This problem is closely related to the validity of the Pauli principle in intermediate states of perturbation theory.Comment: No figure

Fermion masses in a model for spontaneous parity breaking

In this paper we discuss a left-right symmetric model for elementary particles and their connection with the mass spectrum of elementary fermions. The model is based on the group $SU(2)_L\otimes SU(2)_R\otimes U(1)$. New mirror fermions and a minimal set of Higgs particles that breaks the symmetry down to $U(1)_{em}$ are proposed. The model can accommodate a consistent pattern for charged and neutral fermion masses as well as neutrino oscillations. An important consequence of the model is that the connection between the left and right sectors can be done by the neutral vector gauge bosons Z and a new heavy Z'.Comment: 7 pages, 3 figures. Accepted in Eur. Phys. J.

Two definitions of the electric polarizability of a bound system in relativistic quantum theory

For the electric polarizability of a bound system in relativistic quantum theory, there are two definitions that have appeared in the literature. They differ depending on whether or not the vacuum background is included in the system. A recent confusion in this connection is clarified

Validity of Feynman's prescription of disregarding the Pauli principle in intermediate states

Regarding the Pauli principle in quantum field theory and in many-body quantum mechanics, Feynman advocated that Pauli's exclusion principle can be completely ignored in intermediate states of perturbation theory. He observed that all virtual processes (of the same order) that violate the Pauli principle cancel out. Feynman accordingly introduced a prescription, which is to disregard the Pauli principle in all intermediate processes. This ingeneous trick is of crucial importance in the Feynman diagram technique. We show, however, an example in which Feynman's prescription fails. This casts doubts on the general validity of Feynman's prescription