How Well Can We Control Dyslipidemias Through Lifestyle Modifications?

The role for lifestyle modifications to correct dyslipidemia(s) is reviewed. Dietary composition is crucial. Replacing saturated fat with MUFA or n-6 PUFA lowers plasma low-density lipoproteins (LDL) cholesterol and ameliorates the LDL/HDL ratio. Replacing saturated fat with carbohydrates has diverging effects due to the heterogeneity of carbohydrate foods. Diets rich in refined carbohydrates increase fasting and postprandial triglycerides, whereas the consumption of fiber-rich, low GI foods lowers LDL cholesterol with no detrimental effects on triglycerides. The role of polyphenols is debated: available evidence suggests a lowering effect of polyphenol-rich foods on postprandial triglycerides. As for functional foods, health claims on a cholesterol lowering effect of psyllium, beta-glucans and phytosterols are accepted by regulatory agencies. The importance of alcohol intake, weight reduction, and physical activity is discussed. In conclusion, there is evidence that lifestyle affects plasma lipid. A multifactorial approach including multiple changes with additive effects is the best option. This may also ensure feasibility and durability. The traditional Mediterranean way of life can represent a useful model

Fear of COVID-19, depression, anxiety, and their association with Internet addiction disorder in a sample of Italian students

Abstract Background The 2019 Coronavirus (COVID-19) pandemic has led to a worldwide lockdown which has obliged people to stay confined at home, often resulting in social distancing measures and isolation, which can lead to mental health problems as well as to specific Internet-use disorders. This study aims to investigate fear of COVID-19, anxiety, and depression symptoms, and their impact on Internet addiction disorder, modeled as intrapersonal conflicts and interpersonal conflicts, during the COVID-19 epidemic. Method An online questionnaire was administered to 454 Italian students during the first national lockdown. All the recruited participants completed measures including the Depression, Anxiety, and Stress (DASS-21 ), Fear of COVID-19, and Internet addiction . Results The results of the present study demonstrated that fear of COVID-19 was associated with Internet addiction disorder, and fear of COVID-19 mediated the relationship between anxiety and Internet addiction disorder. Finally, controlling for covariates (age and gender), fear of COVID-19 was linked to Internet addiction disorder. Limitations Limitations include the cross-sectional research design and reliance on data exclusively from Italy. Conclusions Results are discussed in the framework of the Interaction-Person-Affect-Cognition-Execution (I-PACE) conceptualization of affective and cognitive responses as strategies for explicating the psycho-pathology of excessive Internet use

I Look, You Smile: The First Mother–Child Communicative Interaction: A Longitudinal Study:

This article discusses the first development of communicative interaction between mother and child, by analyzing the connection between expression and smile. A total of 13 mother–child dyads, recruited at the moment of admission to hospital, participated in the study. Observations have been made when the children were 3, 6, and 9 months old. Mother and child were put in front of each other, and the mother was asked to play freely with her child using a set of toys. The sequential codification of the mother's and the child's behaviors (occurrence and duration) was encoded by two independent observers. Occurrences and durations were analyzed to verify the increase of the interactive dyadic exchange along the three follow-ups. The results highlight an increase in synchronic behaviors in the dyad as the child's age increases, showing the circularity of the dyadic interaction: Mothers increase the occurrences of contingent responses and children increase their competences regarding emotional regulations

Pro-Environmental Behaviors and Well-Being in Adolescence: The Mediating Role of Place Attachment

Adolescents represent the future generation, so it is important to pay attention to behaviors that involve them as actors in social activities and constitute the expression of an adequate growth path. Engaging in pro-environmental behaviors leads adolescents to do something good for themselves, for their own community, and for the place in which they live, and this type of conduct increases their levels of well-being and place attachment. This study examines the association between pro-environmental behavior and personal and social well-being in a sample of 1925 adolescents aged 14 to 20 years. Structural equation analyses showed a direct positive effect of pro-environmental behavior on personal and social well-being as well as place attachment. The latter partially mediated the relationship between pro-environmental behaviors and personal and social well-being. This study is significant in that it provides new data on how pro-environmental behaviors enhance adolescents’ personal and social well-being by potentially ensuring long-term benefits, thereby suggesting that it is important to stimulate, motivate, and recommend these kinds of action

Effects of wholegrain cereal foods on plasma short chain fatty acid concentrations in individuals with the metabolic syndrome

Short chain fatty acids (SCFAs) derived from dietary fiber fermentation by gut microbiota have been identified as one of the mechanisms behind the association between habitual whole-grain intake and a lower risk of cardiometabolic diseases. The aims of the present work are: (1) to evaluate whether a whole-grain wheat-based diet may increase SCFAs concentration, and (2) to identify possible associations between SCFAs and metabolic changes observed after the nutritional intervention

Urine 8-isoprostane in relation to adiposity and insulin resistance in individuals at high cardiometabolic risk

Oxidative stress has been implicated in the pathogenesis of many conditions, including insulin resistance and obesity. However, in vivo data concerning these relationships are scarce and conflicting. Therefore, the aim of this study was to investigate the association of oxidative stress with abdominal adiposity and insulin resistance in individuals at high cardiometabolic risk

The human gut microbiota and glucose metabolism: a scoping review of key bacteria and the potential role of SCFAs

The gut microbiota plays a fundamental role in human nutrition and metabolism and may have direct implications for type 2 diabetes and associated preconditions. An improved understanding of relations between human gut microbiota and glucose metabolism could lead to novel opportunities for type 2 diabetes prevention, but human observational studies reporting on such findings have not been extensively reviewed. Here, we review the literature on associations between gut microbiota and markers and stages of glucose dysregulation and insulin resistance in healthy adults and in adults with metabolic disease and risk factors. We present the current evidence for identified key bacteria and their potential roles in glucose metabolism independent of overweight, obesity, and metabolic drugs. We provide support for SCFAs mediating such effects and discuss the role of diet, as well as metabolites derived from diet and gut microbiota interactions. From 5983 initially identified PubMed records, 45 original studies were eligible and reviewed. alpha Diversity and 45 bacterial taxa were associated with selected outcomes. Six taxa were most frequently associated with glucose metabolism: Akkermansia muciniphila, Bifidobacterium longum, Clostridium leptum group, Faecalibacterium prausnitzii, and Faecalibacterium (inversely associated) and Dorea (directly associated). For Dorea and A. muciniphila, associations were independent of metabolic drugs and body measures. For A. muciniphila and F. prausnitzii, limited evidence supported SCFA mediation of potential effects on glucose metabolism. We conclude that observational studies applying metagenomics sequencing to identify species-level relations are warranted, as are studies accounting for confounding factors and investigating SCFA and postprandial glucose metabolism. Such advances in the field will, together with mechanistic and prospective studies and investigations into diet-gut microbiota interactions, have the potential to bring critical insight into roles of gut microbiota and microbial metabolites in human glucose metabolism and to contribute toward the development of novel prevention strategies for type 2 diabetes, including precision nutrition