Both MC1 and MC3 Receptors Provide Protection From Cerebral Ischemia-Reperfusion-Induced Neutrophil Recruitment.

Objective Neutrophil recruitment is a key process in the pathogenesis of stroke, and may provide a valuable therapeutic target. Targeting the melanocortin receptors (MC) has previously shown to inhibit leukocyte recruitment in peripheral inflammation, however it is not known whether treatments are effective in the unique cerebral microvascular environment. Here, we provide novel research highlighting the effects of the melanocortin peptides on cerebral neutrophil recruitment, demonstrating important yet discrete roles for both MC1 and MC3. Approach and Results Using intravital microscopy, in two distinct murine models of cerebral ischemia-reperfusion (I/R) injury we have investigated melanocortin control over neutrophil recruitment. Following global I/R, pharmacological treatments suppressed pathological neutrophil recruitment. MC1 selective treatment rapidly inhibited neutrophil recruitment while a non-selective MC agonist provided protection even when co-administered with an MC3/4 antagonist, suggesting the importance of early MC1 signaling. However by 2h reperfusion, MC1 mediated effects were reduced, and MC3 anti-inflammatory circuits predominated. Mice bearing a non-functional MC1 displayed a transient exacerbation of neutrophil recruitment following global I/R, which diminished by 2h. However importantly, enhanced inflammatory responses in both MC1 mutant and MC3 -/- mice resulted in increased infarct size and poor functional outcome following focal I/R. Furthermore we utilized an in vitro model of leukocyte recruitment to demonstrate these anti-inflammatory actions are also effective in human cells. Conclusions These studies reveal for the first time melanocortin control over neutrophil recruitment in the unique pathophysiological context of cerebral I/R, whilst also demonstrating the potential therapeutic value of targeting multiple MCs in developing effective therapeutics

Comparison of space-time evolutions of hot/dense matter in sNN\sqrt{s_{NN}}=17 and 130 GeV relativistic heavy ion collisions based on a hydrodynamical model

Based on a hydrodynamical model, we compare 130 GeV/$A$ Au+Au collisions at RHIC and 17 GeV/$A$ Pb+Pb collisions at SPS. The model well reproduces the single-particle distributions of both RHIC and SPS. The numerical solution indicates that huge amount of collision energy in RHIC is mainly used to produce a large extent of hot fluid rather than to make a high temperature matter; longitudinal extent of the hot fluid in RHIC is much larger than that of SPS and initial energy density of the fluid is only 5% higher than the one in SPS. The solution well describes the HBT radii at SPS energy but shows some deviations from the ones at RHIC.Comment: 28 pages, 21 figures, REVTeX4, one figure is added and some figures are replace

Elliptic flow at SPS and RHIC: from kinetic transport to hydrodynamics

Anisotropic transverse flow is studied in Pb+Pb and Au+Au collisions at SPS and RHIC energies. The centrality and transverse momentum dependence at midrapidity of the elliptic flow coefficient v_2 is calculated in the hydrodynamic and low density limits. Hydrodynamics is found to agree well with the RHIC data for semicentral collisions up to transverse momenta of 1-1.5 GeV/c, but it considerably overestimates the measured elliptic flow at SPS energies. The low density limit LDL is inconsistent with the measured magnitude of v_2 at RHIC energies and with the shape of its p_t-dependence at both RHIC and SPS energies. The success of the hydrodynamic model points to very rapid thermalization in Au+Au collisions at RHIC and provides a serious challenge for kinetic approaches based on classical scattering of on-shell particles.Comment: 7 pages incl. 5 figures; submitted to Physics Letters B; Ref. 4 and a few typos corrected; no changes in content

Particlization in hybrid models

In hybrid models, which combine hydrodynamical and transport approaches to describe different stages of heavy-ion collisions, conversion of fluid to individual particles, particlization, is a non-trivial technical problem. We describe in detail how to find the particlization hypersurface in a 3+1 dimensional model, and how to sample the particle distributions evaluated using the Cooper-Frye procedure to create an ensemble of particles as an initial state for the transport stage. We also discuss the role and magnitude of the negative contributions in the Cooper-Frye procedure.Comment: 18 pages, 28 figures, EPJA: Topical issue on "Relativistic Hydro- and Thermodynamics"; version accepted for publication, typos and error in Eq.(1) corrected, the purpose of sampling and change from UrQMD to fluid clarified, added discussion why attempts to cancel negative contributions of Cooper-Frye are not applicable her

The effects of grain shape and frustration in a granular column near jamming

We investigate the full phase diagram of a column of grains near jamming, as a function of varying levels of frustration. Frustration is modelled by the effect of two opposing fields on a grain, due respectively to grains above and below it. The resulting four dynamical regimes (ballistic, logarithmic, activated and glassy) are characterised by means of the jamming time of zero-temperature dynamics, and of the statistics of attractors reached by the latter. Shape effects are most pronounced in the cases of strong and weak frustration, and essentially disappear around a mean-field point.Comment: 17 pages, 19 figure

Hydrodynamical analysis of hadronic spectra in the 130 GeV/nucleon Au+Au collisions

We study one-particle spectra and a two-particle correlation function in the 130 GeV/nucleon Au+Au collisions at RHIC by making use of a hydrodynamical model. We calculate the one-particle hadronic spectra and present the first analysis of Bose-Einstein correlation functions based on the numerical solution of the hydrodynamical equations which takes both longitudinal and transverse expansion into account appropriately. The hydrodynamical model provides excellent agreement with the experimental data in the pseudorapidity and the transverse momentum spectra of charged hadrons, the rapidity dependence of anti-proton to proton ratio, and almost consistent result for the pion Bose-Einstein correlation functions. Our numerical solution with simple freeze-out picture suggests the formation of the quark-gluon plasma with large volume and low net-baryon density.Comment: 7 pages, 8 figures, REVTeX4. Numerical results and figures are correcte

Thermal analysis of production of resonances in relativistic heavy-ion collisions

Production of resonances is considered in the framework of the single-freeze-out model of ultra-relativistic heavy ion collisions. The formalism involves the virial expansion, where the probability to form a resonance in a two-body channel is proportional to the derivative of the phase-shift with respect to the invariant mass. The thermal model incorporates longitudinal and transverse flow, as well as kinematic cuts of the STAR experiment at RHIC. We find that the shape of the pi+ pi- spectral line qualitatively reproduces the preliminary experimental data when the position of the rho peak is lowered. This confirms the need to include the medium effects in the description of the RHIC data. We also analyze the transverse-momentum spectra of rho, K*(892), and f_0(980), and find that the slopes agree with the observed values. Predictions are made for eta, eta', omega, phi, Lambda(1520), and Sigma(1385).Comment: minor modifications, a reference adde

Collective flow and two-pion correlations from a relativistic hydrodynamic model with early chemical freeze out

We investigate the effect of early chemical freeze-out on radial flow, elliptic flow and HBT radii by using a fully three dimensional hydrodynamic model. When we take account of the early chemical freeze-out, the space-time evolution of temperature in the hadron phase is considerably different from the conventional model in which chemical equilibrium is always assumed. As a result, we find that radial and elliptic flows are suppressed and that the lifetime and the spatial size of the fluid are reduced. We analyze the p_t spectrum, the differential elliptic flow, and the HBT radii at the RHIC energy by using hydrodynamics with chemically non-equilibrium equation of state.Comment: One subsection and two figures adde

Hydrodynamics and Flow

In this lecture note, we present several topics on relativistic hydrodynamics and its application to relativistic heavy ion collisions. In the first part we give a brief introduction to relativistic hydrodynamics in the context of heavy ion collisions. In the second part we present the formalism and some fundamental aspects of relativistic ideal and viscous hydrodynamics. In the third part, we start with some basic checks of the fundamental observables followed by discussion of collective flow, in particular elliptic flow, which is one of the most exciting phenomenon in heavy ion collisions at relativistic energies. Next we discuss how to formulate the hydrodynamic model to describe dynamics of heavy ion collisions. Finally, we conclude the third part of the lecture note by showing some results from ideal hydrodynamic calculations and by comparing them with the experimental data.Comment: 40 pages, 35 figures; lecture given at the QGP Winter School, Jaipur, India, Feb.1-3, 2008; to appear in Springer Lecture Notes in Physic

Parton coalescence at RHIC

Using a covariant coalescence model, we study hadron production in relativistic heavy ion collisions from both soft partons in the quark-gluon plasma and hard partons in minijets. Including transverse flow of soft partons and independent fragmentation of minijet partons, the model is able to describe available experimental data on pion, kaon, and antiproton spectra. The resulting antiproton to pion ratio is seen to increase at low transverse momenta and reaches a value of about one at intermediate transverse momenta, as observed in experimental data at RHIC. A similar dependence of the antikaon to pion ratio on transverse momentum is obtained, but it reaches a smaller value at intermediate transverse momenta. At high transverse momenta, the model predicts that both the antiproton to pion and the antikaon to pion ratio decrease and approach those given by the perturbative QCD. Both collective flow effect and coalescence of minijet partons with partons in the quark-gluon plasma affect significantly the spectra of hadrons with intermediate transverse momenta. Elliptic flows of protons, Lambdas, and Omegas have also been evaluated from partons with elliptic flows extracted from fitting measured pion and kaon elliptic flows, and they are found to be consistent with available experimental data.Comment: 12 pages, 11 figure