M-BIM: a new tool for the Galleria dell’Accademia di Firenze

[EN] The paper deals with an ongoing research activity for developing a Building Information Model (BIM) for the facility and collections management of museums. The BIM success lies not only in its application for the design and construction of buildings but also because it helps the information management of a building throughout its life cycle. Compared to other activities, in museums management, the container/content relationship is essential for the preventive conservation of artworks, according to national and international guidelines. Then, an effective BIM-based museum information system linked to external databases (called M-BIM) should include also the art collections for managing information regarding both the building and artworks by 3D objects handling. This facilitates the management of the procedures prescribed by international best practices (as the facility and conservation reports set up for the loan of artworks) or by Italian regulations (as to check the compliance of a museum with the minimum standards or to archive renovations and temporary exhibitions). The proposed methodology has been tested on the Galleria dell’Accademia di Firenze (Florence, Italy), situated in a complex heritage building. Starting from data acquired during a laser scanner survey carried out in 2011, a HBIM of the whole building has been created. Then, the sculptures and paintings of a consistent part of the museum have been modelled with different approaches and inserted as BIM objects. Artworks instances include 3D geometry and physical data (dimensions, materials, weight, etc.), other data are obtained from links to already existing external catalogues. A database conceptual model has been formalised, according to INSPIRE Consolidated Unified Modelling Language (UML) of the INSPIRE Directive, with the aim to maintain the independence of the BIM approach but improving data connection with other databases and sources.Highlights:A holistic information management system for museums (M-BIM) is proposed, including both information on the building and the collections.International and Italian guidelines, and best practices on museums management are compared.The Galleria dell’Accademia di Firenze is used as a case study for testing the application of M-BIM on a heritage building.[ES] El artículo trata una investigación en curso que aborda el desarrollo del modelado de información de la construcción (BIM) para la gestión de instalaciones y colecciones de museos. El éxito del BIM no reside sólo en su aplicación en el diseño y la construcción de edificios, sino también en que ayuda en la gestión de la información de una construcción durante todo su ciclo de vida. En comparación con otras actividades, en la gestión de los museos, la relación contenedor/contenido es esencial en la conservación preventiva de las obras de arte, de acuerdo con las directrices nacionales e internacionales. Entonces, un sistema eficaz de información museística mediante BIM y que se enlace con bases de datos externas (denominado M-BIM) debería incluir las colecciones de arte para la gestión de la información relativa tanto al edificio como a las obras de arte mediante la manipulación de objetos en 3D. Esto facilita la gestión de los procedimientos prescritos por las mejores prácticas internacionales (como los informes de instalación y conservación establecidos para el préstamo de obras de arte) o por la normativa italiana (como el control de la conformidad de un museo con los estándares mínimos o almacenar renovaciones y exposiciones temporales). La metodología propuesta se ha probado en la Galleria dell’Accademia di Firenze (Italia), situada en un edificio patrimonial de gran complejidad. Se ha creado un HBIM de todo el edificio a partir de los datos capturados en 2011 en un levantamiento con escáner láser. Después, las esculturas y pinturas de una parte consistente del museo se han modelado con diferentes enfoques e insertado como objetos BIM. Los ejemplos de obras de arte incluyen geometría 3D y datos físicos (dimensiones, materiales, peso, etc.), otros datos se obtienen a partir de enlaces a catálogos externos ya existentes. Se ha formalizado un modelo conceptual de bases de datos, según el el lenguaje unificado de modelado (UML) Consolidado INSPIRE de la Directiva INSPIRE, con el objetivo de mantener la independencia del procedimiento BIM, pero mejorando la conexión de los datos con otras bases de datos y fuentes.The research has been carried out as part of the GAMHer project: Geomatics Data Acquisition and Management for Landscape and Built Heritage in a European Perspective, PRIN:–Bando 2015, Prot. 2015HJLS7E.Tucci, G.; Conti, A.; Fiorini, L.; Corongiu, M.; Valdambrini, N.; Matta, C. (2019). M-BIM: una nueva herramienta para la Galleria dell'Accademia di Firenze (Florencia). Virtual Archaeology Review. 10(21):40-55. https://doi.org/10.4995/var.2019.11943SWORD4055102

Autoantibody profile in systemic lupus erythematosus with psychiatric manifestations: a role for anti-endothelial-cell antibodies

This study was performed to determine the correlation between psychiatric manifestations and several autoantibodies that might participate in the pathogenesis of psychiatric disorders in the course of systemic lupus erythematosus (SLE). Fifty-one unselected outpatients with SLE were enrolled. Psychiatric evaluation was performed according to the Diagnostic and Statistical Manual of Mental Disorders, 4th edition. The prevalence of antibodies against endothelial cells (AECA), cardiolipin, β2 glycoprotein I, Ro, Ro52, La, glial fibrillary acidic protein, ribosomal P protein, dsDNA, and nucleosomes was assessed by experimental and commercial enzyme-linked immunosorbent assays. According to the cutoff value, AECA were present in 11 of 17 (64.7%) SLE patients with psychosis and mood disorders and in 10 of 34 (29.4%) patients without psychiatric manifestations other than anxiety (P = 0.03). Moreover, the AECA binding index was significantly higher in the first group (P = 0.03). Conversely, no significant correlation was found between the presence of the other autoantibodies studied and psychiatric involvement. The results of this study suggest a relationship between AECA and psychosis and mood disorders in SLE, supporting the hypothesis of a biological origin of these disturbances

Variability in genes regulating vitamin D metabolism is associated with vitamin D levels in type 2 diabetes

Mortality rate is increased in type 2 diabetes (T2D). Low vitamin D levels are associated with increased mortality risk in T2D. In the general population, genetic variants affecting vitamin D metabolism (DHCR7 rs12785878, CYP2R1 rs10741657, GC rs4588) have been associated with serum vitamin D. We studied the association of these variants with serum vitamin D in 2163 patients with T2D from the "Sapienza University Mortality and Morbidity Event Rate (SUMMER) study in diabetes". Measurements of serum vitamin D were centralised. Genotypes were obtained by Eco™ Real-Time PCR. Data were adjusted for gender, age, BMI, HbA1c, T2D therapy and sampling season. DHCR7 rs12785878 (p = 1 x 10-4) and GC rs4588 (p = 1 x 10-6) but not CYP2R1 rs10741657 (p = 0.31) were significantly associated with vitamin D levels. One unit of a weighted genotype risk score (GRS) was strongly associated with vitamin D levels (p = 1.1 x 10-11) and insufficiency (<30 ng/ml) (OR, 95%CI = 1.28, 1.16-1.41, p = 1.1 x 10-7). In conclusion, DHCR7 rs12785878 and GC rs4588, but not CYP2R1 rs10741657, are significantly associated with vitamin D levels. When the 3 variants were considered together as GRS, a strong association with vitamin D levels and vitamin D insufficiency was observed, thus providing robust evidence that genes involved in vitamin D metabolism modulate serum vitamin D in T2D

Environmental and Occupational Risk Factors of Amyotrophic Lateral Sclerosis: A Population-Based Case-Control Study

Objectives: Amyotrophic lateral sclerosis (ALS) is a progressive and fatal neurodegenerative disease with still unknown etiology. We aimed at investigating the association between environmental and occupational factors with ALS risk. Methods: We performed a population-based case-control study in four Italian provinces (Catania, Modena, Novara, and Reggio Emilia) by administration of tailored questionnaires to ALS cases (n = 95) and randomly selected population referents (n = 135). We estimated ALS risk by calculating the odds ratio (OR) with its 95% confidence interval (CI) using an unconditional logistic regression model. Results: We found a positive association with disease risk for history of occupation in the agricultural sector (OR = 2.09, 95% CI 0.79-7.54), especially for longer than 10 years (OR = 2.72, 95% 1.02-7.20). Overall occupational exposure to solvents also suggested a positive association, especially for thinners (OR = 2.27, 95% CI 1.14-4.54) and paint removers (OR = 2.01, 95% CI 0.90-4.48). Both occupational and environmental exposure to electromagnetic fields show a slightly increased risk with OR = 1.69 (95% CI 0.70-4.09) and 2.41 (95% CI 1.13-5.12), respectively. Occupational but not environmental exposure to pesticides (OR = 1.22, 95% CI 0.63-2.37), particularly fungicides, and exposure to metals (OR = 4.20, 95% CI 1.88-9.38), particularly lead, mercury, and selenium, showed an imprecise but positive association. Finally, there was an indication of increased risk for living in proximity to water bodies. Conclusions: Despite the caution that needs to be used due to some study limitations, such as the low number of exposed subjects and the possibility of recall bias, these results suggest the potential role of some environmental and occupational factors in ALS etiology

Clinical and Lifestyle Factors and Risk of Amyotrophic Lateral Sclerosis: A Population-Based Case-Control Study

Background: Amyotrophic lateral sclerosis (ALS) is a progressive, fatal neurodegenerative disease of the motor neurons. The etiology of ALS remains largely unknown, particularly with reference to the potential environmental determinants. Methods: We performed a population-based case-control study in four provinces from both Northern and Southern Italy in order to assess non-genetic ALS risk factors by collecting through tailored questionnaires information about clinical and lifestyle factors. We estimated ALS risk by calculating odds ratio (OR) with its 95% confidence interval (CI) using unconditional logistic regression models adjusted for sex, age and educational attainment. Results: We recruited 230 participants (95 cases and 135 controls). We found a possible positive association of ALS risk with trauma, particularly head trauma (OR = 2.61, 95% CI 1.19-5.72), electric shock (OR = 2.09, 95% CI 0.62-7.06), and some sports, although at a competitive level only. In addition, our results suggest an increased risk for subjects reporting use of private wells for drinking water (OR = 1.38, 95% CI 0.73-2.27) and for use of herbicides during gardening (OR = 1.95, 95% CI 0.88-2.27). Conversely, there was a suggestion of an inverse association with overall fish consumption (OR = 0.27, 95% CI 0.12-0.60), but with no dose-response relation. Consumption of some dietary supplements, namely those containing amino acids and, in the Southern Italy population, vitamins and minerals such as selenium, seemed associated with a statistically imprecise increased risk. Conclusions: Our results suggest a potential etiologic role a number of clinical and lifestyle factors with ALS risk. However, caution is needed due to some study limitations. These include the small sample size and the low number of exposed subjects, which affect statistical precision of risk estimates, the potential for exposure misclassification, and the uncertainties about mechanisms underpinning the possible association between these factors and disease risk

Biomimetic antimicrobial cloak by graphene-oxide agar hydrogel

Antibacterial surfaces have an enormous economic and social impact on the worldwide technological fight against diseases. However, bacteria develop resistance and coatings are often not uniform and not stable in time. The challenge is finding an antibacterial coating that is biocompatible, cost-effective, not toxic, and spreadable over large and irregular surfaces. Here we demonstrate an antibacterial cloak by laser printing of graphene oxide hydrogels mimicking the Cancer Pagurus carapace. We observe up to 90% reduction of bacteria cells. This cloak exploits natural surface patterns evolved to resist to microorganisms infection, and the antimicrobial efficacy of graphene oxide. Cell integrity analysis by scanning electron microscopy and nucleic acids release show bacteriostatic and bactericidal effect. Nucleic acids release demonstrates microorganism cutting, and microscopy reveals cells wrapped by the laser treated gel. A theoretical active matter model confirms our findings. The employment of biomimetic graphene oxide gels opens unique possibilities to decrease infections in biomedical applications and chirurgical equipment; our antibiotic-free approach, based on the geometric reduction of microbial adhesion and the mechanical action of Graphene Oxide sheets, is potentially not affected by bacterial resistance

Development of a Tumor-Selective Approach to Treat Metastatic Cancer

BACKGROUND: Patients diagnosed with metastatic cancer have almost uniformly poor prognoses. The treatments available for patients with disseminated disease are usually not curative and have side effects that limit the therapy that can be given. A treatment that is selectively toxic to tumors would maximize the beneficial effects of therapy and minimize side effects, potentially enabling effective treatment to be administered. METHODS AND FINDINGS: We postulated that the tumor-tropic property of stem cells or progenitor cells could be exploited to selectively deliver a therapeutic gene to metastatic solid tumors, and that expression of an appropriate transgene at tumor loci might mediate cures of metastatic disease. To test this hypothesis, we injected HB1.F3.C1 cells transduced to express an enzyme that efficiently activates the anti-cancer prodrug CPT-11 intravenously into mice bearing disseminated neuroblastoma tumors. The HB1.F3.C1 cells migrated selectively to tumor sites regardless of the size or anatomical location of the tumors. Mice were then treated systemically with CPT-11, and the efficacy of treatment was monitored. Mice treated with the combination of HB1.F3.C1 cells expressing the CPT-11-activating enzyme and this prodrug produced tumor-free survival of 100% of the mice for >6 months (P<0.001 compared to control groups). CONCLUSIONS: The novel and significant finding of this study is that it may be possible to exploit the tumor-tropic property of stem or progenitor cells to mediate effective, tumor-selective therapy for metastatic tumors, for which no tolerated curative treatments are currently available