651 research outputs found
Postoperative pain surveys in Italy from 2006 and 2012. (POPSI and POPSI-2)
OBJECTIVE:
Despite established standards, effective treatments, and evidence-based guidelines, postoperative pain control in Italy and other parts of the world remains suboptimal. Pain control has been recognized as a fundamental human right. Effective treatments exist to control postsurgical pain. Inadequate postoperative analgesia may prolong the length of hospital stays and may adversely impact outcomes.
MATERIALS AND METHODS:
The same multiple-choice survey administered at the SIAARTI National Congress in Perugia in 2006 (n=588) was given at the SIAARTI National Congress in Naples, Italy in 2012 (n=635). The 2012 survey was analysed and compared to the 2006 results.
RESULTS:
Postoperative pain control in Italy was less than optimal in 2006 and showed no substantial improvements in 2012. Geographical distinctions were evident with certain parts of Italy offering better postoperative pain control than other. Fewer than half of hospitals represented had an active Acute Pain Service (APS) and only about 10% of postsurgical patients were managed according to evidence-based guidelines. For example, elastomeric pumps for continuous IV infusion are commonly used in Italy, although patient-controlled analgesia systems are recommended in the guidelines. The biggest obstacles to optimal postoperative pain control reported by respondents could be categorized as organizational, cultural, and economic.
CONCLUSIONS:
There is considerable room for improvement in postoperative pain control in Italy, specifically in the areas of clinical education, evidence-based treatments, better equipment, and implementation of active APS departments in more hospitals. Two surveys taken six years apart in Italy reveal, with striking similarity, that there are many unmet needs in postoperative pain control and that Italy still falls below European standards for postoperative pain control
Molecular evidence of incipient speciation within Anopheles gambiae s.s. in West Africa
We karyotyped and identified by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) analysis Anopheles gambiae s.s. samples collected in several African countries. The data show the existence of two non-panmictic molecular forms, named S and M, whose distribution extended from forest to savannahs, Mosquitoes of the S and M forms are homosequential standard for chromosome-2 inversions in forest areas. In dry savannahs, S is characterized mainly by inversion polymorphisms typical of Savanna and Bamako chromosomal forms, while M shows chromosome-2 arrangements typical of Mopti and/or Savanna and/or Bissau, depending on its geographical origin. Chromosome-2 inversions therefore seem to be involved in ecotypic adaptation rather than in mate-recognition systems. Strong support for the reproductive isolation of S and M in Ivory Coast comes from the observation that the kdr allele is found at high frequencies in S specimens and not at all in chromosomal identical M specimens. However, the kdr allele does not segregate with molecular forms in Benin
The liquid-glass transition of silica
We studied the liquid-glass transition of by means of replica theory,
utilizing an effective pair potential which was proved to reproduce a few
experimental features of silica. We found a finite critical temperature ,
where the system undergoes a phase transition related to replica symmetry
breaking, in a region where experiments do not show any transition. The
possible sources of this discrepancy are discussed.Comment: 14 pages, 6 postscript figures. Revised version accepted for
pubblication on J.Chem.Phy
Potential energy landscape of finite-size mean-field models for glasses
connected spin-glass models with a discontinuous transition. In the
thermodynamic limit the equilibrium properties in the high temperature phase
are described by the schematic Mode Coupling Theory of super-cooled liquids. We
show that {\it finite-size} fully connected spin-glass models do exhibit
properties typical of Lennard-Jones systems when both are near the critical
glass transition, where thermodynamics is ruled by energy minima distribution.
Our study opens the way to consider activated processes in real glasses through
finite-size corrections (i.e. calculations beyond the saddle point
approximation) in mean-field spin-glass models.Comment: 8 pages, 3 postscript figures, EPL format, improved versio
The challenge of perioperative pain management in opioid-tolerant patients
The increasing number of opioid users among chronic pain patients, and opioid abusers among the general population, makes perioperative pain management challenging for health care professionals. Anesthesiologists, surgeons, and nurses should be familiar with some pharmacological phenomena which are typical of opioid users and abusers, such as tolerance, physical dependence, hyperalgesia, and addiction. Inadequate pain management is very common in these patients, due to common prejudices and fears. The target of preoperative evaluation is to identify comorbidities and risk factors and recognize signs and symptoms of opioid abuse and opioid withdrawal. Clinicians are encouraged to plan perioperative pain medications and to refer these patients to psychiatrists and addiction specialists for their evaluation. The aim of this review was to give practical suggestions for perioperative management of surgical opioid-tolerant patients, together with schemes of opioid conversion for chronic pain patients assuming oral or transdermal opioids, and patients under maintenance programs with methadone, buprenorphine, or naltrexone
Numerical study of the disordered Poland-Scheraga model of DNA denaturation
We numerically study the binary disordered Poland-Scheraga model of DNA
denaturation, in the regime where the pure model displays a first order
transition (loop exponent ). We use a Fixman-Freire scheme for the
entropy of loops and consider chain length up to , with
averages over samples. We present in parallel the results of various
observables for two boundary conditions, namely bound-bound (bb) and
bound-unbound (bu), because they present very different finite-size behaviors,
both in the pure case and in the disordered case. Our main conclusion is that
the transition remains first order in the disordered case: in the (bu) case,
the disorder averaged energy and contact densities present crossings for
different values of without rescaling. In addition, we obtain that these
disorder averaged observables do not satisfy finite size scaling, as a
consequence of strong sample to sample fluctuations of the pseudo-critical
temperature. For a given sample, we propose a procedure to identify its
pseudo-critical temperature, and show that this sample then obeys first order
transition finite size scaling behavior. Finally, we obtain that the disorder
averaged critical loop distribution is still governed by in
the regime , as in the pure case.Comment: 12 pages, 13 figures. Revised versio
Liquid Limits: The Glass Transition and Liquid-Gas Spinodal Boundaries of Metastable Liquids
The liquid-gas spinodal and the glass transition define ultimate boundaries
beyond which substances cannot exist as (stable or metastable) liquids. The
relation between these limits is analyzed {\it via} computer simulations of a
model liquid. The results obtained indicate that the liquid - gas spinodal and
the glass transition lines intersect at a finite temperature, implying a glass
- gas mechanical instability locus at low temperatures. The glass transition
lines obtained by thermodynamic and dynamic criteria agree very well with each
other.Comment: 5 pages, 4 figures, to appear in Phys. Rev. Let
Fluctuation dissipation ratio in an aging Lennard-Jones glass
By using extensive Molecular Dynamics simulations, we have determined the
violation of the fluctuation-dissipation theorem in a Lennard-Jones liquid
quenched to low temperatures. For this we have calculated , the ratio
between a one particle time-correlation function and the associated
response function. Our results are best fitted by assuming that is a
discontinuous, piecewise constant function. This is similar to what is found in
spin systems with one step replica symmetry breaking. This strengthen the
conjecture of a similarity between the phase space structure of structural
glasses and such spin systems.Comment: improved data and metho
Statistical Physics of Structural Glasses
This paper gives an introduction and brief overview of some of our recent
work on the equilibrium thermodynamics of glasses. We have focused onto first
principle computations in simple fragile glasses, starting from the two body
interatomic potential. A replica formulation translates this problem into that
of a gas of interacting molecules, each molecule being built of atoms, and
having a gyration radius (related to the cage size) which vanishes at zero
temperature. We use a small cage expansion, valid at low temperatures, which
allows to compute the cage size, the specific heat (which follows the Dulong
and Petit law), and the configurational entropy. The no-replica interpretation
of the computations is also briefly described. The results, particularly those
concerning the Kauzmann tempaerature and the configurational entropy, are
compared to recent numerical simulations.Comment: 21 pages, 6 figures, to appear in the proceedings of the Trieste
workshop on "Unifying Concepts in Glass Physics
- …