Revelations About Carotid Body Function Through its Pathological Role in Resistant Hypertension

Much recent attention has been given to the carotid body because of its potential role in cardiovascular disease states. One disease, neurogenic hypertension, characterised by excessive sympathetic activity, appears dependent on carotid body activity that may or may not be accompanied by sleep-disordered breathing. Herein, we review recent literature suggesting that the carotid body acquires tonicity in hypertension. We predict that carotid glomectomy will be a powerful way to temper excessive sympathetic discharge in diseases such as hypertension. We propose a model to explain that signalling from the ‘hypertensive’ carotid body is tonic, and hypothesise that there will be a sub-population of glomus cells that channel separately into reflex pathways controlling sympathetic motor outflows

The effectiveness of lung cancer MDT and the role of respiratory physicians

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Bactericidal action of ofloxacin, sulbactam-ampicillin, rifampin, and isoniazid on logarithmic- and stationary-phase cultures of Mycobacterium tuberculosis

The bactericidal actions of ofloxacin and sulbactam-ampicillin, alone and in combination with rifampin and isoniazid, on exponential-phase and stationary-phase cultures of a drug-susceptible isolate of Mycobacterium tuberculosis were studied in vitro. In exponential-phase cultures, all drugs were bactericidal. with the higher concentrations of ofloxacin (5 μg/ml) and sulbactam-ampicillin (15 μg of ampicillin per ml) being as bactericidal as 1 μg of isoniazid per ml or 1 μg of rifampin per ml. In two-drug combinations. both drugs increased the levels of activity of isoniazid and rifampin and were almost as bactericidal as isoniazid-rifampin; they also appeared to increase the level of activity of isoniazid-rifampin in three-drug combinations. In contrast. ofloxacin and sulbactam-ampicillin had little bactericidal activity against stationary-phase cultures and were less active than isoniazid or rifampin alone. Furthermore. in two-drug or three-drug combinations, they did not increase the level of activity of isoniazid, rifampin, or isoniazid-rifampin. These findings suggest that ofloxacin and sulbactam-ampicillin are likely to be most useful in the early stages of treatment and in preventing the emergencc of resistance to other drugs hut are unlikely to be effective as sterilizing drugs helping to kill persisting lesional bacilli

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Not AvailableFood security of the country has been improved due to green revolution and enhancement of cereal production. However, recent surveys showed 35.8% of children suffer from malnutrition in India. The Indian Council of Agricultural Research has taken lead for the biofortification of cereal crops based on earlier national and international research efforts, targeting the enhancement of nutrients in staple food crops. In this article, the significant progress made in rice, wheat, maize and millets for identification of genotypes, development, evaluation and release of the varieties with high nutrient contents and their bioavailability studies is discussedNot Availabl