8 research outputs found
Combination of aspirin with essential fatty acids is superior to aspirin alone to prevent or ameliorate sepsis or ARDS
Superior performance of a paraaortic counterpulsation device compared to the intraaortic balloon pump
The purpose of this study was to compare the hemodynamic effectiveness
of a 30-ml stroke volume paraaortic counterpulsation device (PACD),
presenting the advantages of ease of implantation and driving by a
standard intraaortic balloon pump (IABP) console (Datascope 96,
Datascope Corp., Montvale, NJ, USA) to that of a 40-ml IABP, in the
setting of experimental heart failure. In an acute heart failure model,
the IABP was placed in the descending aorta and the PACD in the
ascending aorta of eight pigs. Both devices were driven by the same
system, and hemodynamic measurements were obtained with and without
mechanical assistance. The two pumps significantly reduced the systolic
and end-diastolic aortic pressures, but the PACD reduced the latter more
effectively (42.6 +/- 18.1% vs 11.0 +/- 9.9%,p = 0.0001). Both pumps
provided significant aortic diastolic augmentation, but the
counterpulsation wave of the PACD was significantly greater
(augmentation of 44.8 +/- 22.2% vs 37.6 +/- 15.6%, p = 0.031). Both
lowered the end-diastolic left ventricular pressure with a trend toward
PACD superiority (24.2 +/- 13.7% vs 19.7 +/- 13.5%,p = 0.064). It is
concluded that the PACD, even with smaller stroke volume, is more
effective than the IABP. The simplicity of its implantation, together
with the ability of the standard IABP consoles to control its function,
make it a promising device for mechanical assistance of the failing
heart
Diagnosis of sepsis from a drop of blood by measurement of spontaneous neutrophil motility in a microfluidic assay
Impact of Coronary Dominance on In-Hospital Outcomes after Percutaneous Coronary Intervention in Patients with Acute Coronary Syndrome
Blood platelets and sepsis pathophysiology: A new therapeutic prospect in critical ill patients?
Beyond haemostasis, platelets have emerged as versatile effectors of the immune response. The contribution of platelets in inflammation, tissue integrity and defence against infections has considerably widened the spectrum of their role in health and disease. Here, we propose a narrative review that first describes these new platelet attributes. We then examine their relevance to microcirculatory alterations in multi-organ dysfunction, a major sepsis complication. Rapid progresses that are made on the knowledge of novel platelet functions should improve the understanding of thrombocytopenia, a common condition and a predictor of adverse outcome in sepsis, and may provide potential avenues for management and therapy