Failure prediction of adhesively bonded lap joints between metal and composite adherends

Most of the modern civilian or military aircrafts use advanced composite materials for their primary structural components, in addition to metals. The components are joined together by using either fastener or adhesively bonded joints. But with the introduction of composite materials in aircraft industries, adhesively bonded lap joints are most preferred. This is due to the fact that they develop smooth load transfer and fewer points of stress concentration as compared to fastener joints. The failure prediction of such joints is extremely important, to avoid catastrophic failures during aircraft service period. In the present investigation, an adhesively bonded lap joint between metal-composite (i.e., Al 2024-T3/CFRP) adherends bonded with Redux 319-A adhesive has been analyzed using finite element method considering geometric non-linearity and incorporating adhesive material nonlinear behavior. The failure has been predicted using plastic zone size criterion of adhesive material, which is innovative approach of this study. Also, experimental program is carried out on such joints to correlate with the predicted failure load obtained from numerical model. In this study, the failure of joint is assumed to take place due to adhesive failure only. Plastic zone size in adhesive at failure load of joint is taken as 15 % of the lap length as established from the previous work of the authors. It is observed that the failure load of the adhesively bonded lap joint between composite-metal adherends as obtained from numerical model is well compared with that obtained from experimental study. Results are discussed

Strength Prediction of Adhesively Bonded Joints using Plastic Zone Size Criterion

The prediction of the strength of adhesively bonded joints has been an issue of considerable interest in literature. This exercise requires numerical techniques combined with experimental programs and matching the two to arrive at a viable criterion. The configurations used for the study are single lap adhesively bonded joints between (i) aluminium (Al) – aluminium (Al) and (ii) carbon fibre reinforced composite (CFRP) and aluminium adherends with Redux-319A epoxy. Geometric and material non-linear finite element analysis was conducted using the NASTRAN software package to establish the proposed plastic zone size (PZS) failure criterion. On the same configuration both experimental program for joint strength and numerical analysis were conducted. The plastic zone size corresponding to failure load was initially estimated from Al-Al joints. The same value was used to predict failure load for CFRP-Al bonded joint. The average experimental value and numerical predictions for CFRP-Al joints matched within 7%. This study suggests an alternative method of strength prediction of adhesively bonded single lap joint in presence of inelastic behaviour of adhesive material

MEASUREMENT OF WOOD DUST PARTICLE SIZE BY OPTICAL MICROSCOPY TECHNIQUE AND LONG-TERM EFFECT ON SAWMILL WORKERS: A RANDOM STUDY

ABSTRACTObjective: Sawmill workers are exposed to wood dust particles of different sizes, and they cause different respiratory effects depending on the size,physical, and chemical nature of the dust particle and also it is related to the duration of exposure.Introduction: Many studies are done in concern with respiratory effects of wood dust exposure and its toxicity on sawmill workers. Only few studieshave been done regarding measurement of particle size. Hence, this study has been undertaken. To measure the size of wood dust particle of sawmillsto which the workers are exposed to and also to study significance to the duration of exposure to different sizes of wood dust and effect on long-termexposure.Methods: Random samples collected from three different places of different sawmills where there is maximum production and exposure of wooddust. The samples were analyzed and particle was measured using optical microscopy technique. 50 healthy participants from these mills wereassessed for chest expansion in cm and compared against years of wood dust exposure.Results and Conclusion: Overall, it is observed that percentage distribution of size of wood dust particles: 45.9% <0.1 μm, 23.3% 2.5-10,22.3% 0.1-2.5 μm, and 8.5% >10 μm. It may be concluded that occupational hazards are directly proportional to the size of the particle and durationof exposure to wood dust particles. Chest expansion in cm was also found reduced with the increase in the years of exposure to wood dust.Keywords: Sawmill workers, Wood dust, Optical microscopy, Chest expansion

The tensile fatigue behaviour of a silica nanoparticle-modified glass fibre reinforced epoxy composite

Abstract An anhydride-cured thermosetting epoxy polymer was modified by incorporating 10 wt.% of welldispersed 20 nm diameter silica nanoparticles. The stress-controlled tensile fatigue behaviour at a stress ratio of R = 0.1 was investigated for bulk specimens of the neat and the silica-modified epoxy. The addition of the silica nanoparticles increased the fatigue life by about three to four times. The neat and the nanoparticle-modified epoxy resins were used to fabricate glass fibre reinforced plastic (GFRP) composite laminates by resin infusion under flexible tooling (RIFT). Tensile fatigue tests were performed on these composites, during which the matrix cracking and stiffness degradation was monitored. The fatigue life of the GFRP composite was increased by about three to four times due to the silica nanoparticles. Suppressed matrix cracking and a reduced crack propagation rate in the nanoparticle-modified matrix were observed to contribute towards the enhanced fatigue life of the composite containing the silica nanoparticles

The tensile fatigue behavior of a glass-fiber reinforced plastic composite using a hybrid-toughened epoxy matrix

ABSTRACT A thermosetting epoxy-polymer was modified by incorporating 9 wt.% of carboxyl-terminated butadiene-acrylonitrile (CTBN) rubber microparticles and 10 wt.% of silica nanoparticles. The tensile fatigue behaviour at a stress ratio, R = 0.1 for both the neat (i.e. unmodified) epoxy-polymer and the hybridepoxy polymer was first investigated. The fatigue life of the hybrid-epoxy * Corresponding author: Tel. +91-80-2508 6310 ; Fax: +91-80-2508 6301 E-mail address: [email protected] (CM Manjunatha) 2 polymer was about six to ten times higher than that the neat-epoxy polymer. Secondly, the neat and the hybrid-epoxy resins were infused into a quasiisotropic lay-up, E-glass fiber fabric via a 'Resin Infusion under Flexible Tooling' (RIFT) set-up to fabricate glass-fiber reinforced-plastic (GFRP) composite panels. The tensile fatigue tests at a stress ratio, R = 0.1 were performed on both of these GFRP composites during which the matrix cracking and stiffness degradation were routinely monitored. The fatigue life of the GFRP composite increased by about six to ten times due to employing the hybrid-epoxy matrix, compared to the neat-epoxy matrix. Suppressed matrix cracking and a reduced crack propagation rate were observed in the hybrid-epoxy matrix, which resulted from the various toughening micromechanisms induced by the presence of both the rubber microparticles and silica nanoparticles. These factors were considered to contribute towards the enhanced fatigue life which was observed for the GFRP composite employing the hybrid-epoxy matrix

Malignant melanoma of the mandibular gingiva

Oral malignant melanoma is an infrequent neoplasia making up less than 1% of all melanomas, which exhibits much more aggressive behavior than those found on the skin. We present an aggressive case of oral malignant melanoma located on the mandibular gingiva in a 24-year-old male patient, who developed metastases to not only the regional lymph nodes but also the lungs and liver. The advanced stage of the disease contraindicated any surgical intervention and palliative chemotherapy was planned

Silkworm Thermal Biology: A Review of Heat Shock Response, Heat Shock Proteins and Heat Acclimation in the Domesticated Silkworm, Bombyx mori

Heat shock proteins (HSPs) are known to play ecological and evolutionary roles in this postgenomic era. Recent research suggests that HSPs are implicated in cardiovascular biology and disease development, proliferation and regulation of cancer cells, cell death via apoptosis, and several other key cellular functions. These activities have generated great interest amongst cell and molecular biologists, and these biologists are keen to unravel other hitherto unknown potential functions of this group of proteins. Consequently, the biological significance of HSPs has led to cloning and characterization of genes encoding HSPs in many organisms including the silkworm, Bombyx mori L. (Lepidoptera: Bombycidae). However, most of the past investigations in B. mori were confined to expression of HSPs in tissues and cell lines, whereas information on their specific functional roles in biological, physiological, and molecular processes is scarce. Naturally occurring or domesticated polyvoltines (known to be the tropical race) are more resistant to high temperatures and diseases than bi- or univoltines (temperate races). The mechanism of ecological or evolutionary modification of HSPs during the course of domestication of B. mori - particularly in relation to thermotolerance in geographically distinct races/strains - is still unclear. In addition, the heat shock response, thermal acclimation, and hardening have not been studied extensively in B. mori compared to other organisms. Towards this, recent investigations on differential expression of HSPs at various stages of development, considering the concept of the whole organism, open ample scope to evaluate their biological and commercial importance in B. mori which has not been addressed in any of the representative organisms studied so far. Comparatively, heat shock response among different silkworm races/strains of poly-, bi-, and univoltines varies significantly and thermotolerance increases as the larval development proceeds. Hence, this being the first review in this area, an attempt has been made to collate all available information on the heat shock response, HSPs expression, associated genes, amino acid sequences, and acquired/unacquired thermotolerance. The aim is to present this as a valuable resource for addressing the gap in knowledge and understanding evolutionary significance of HSPs between domesticated (B. mori) and non-domesticated insects. It is believed that the information presented here will also help researchers/breeders to design appropriate strategies for developing novel strains for the tropics

Enteral lactoferrin supplementation for very preterm infants: a randomised placebo-controlled trial

Background Infections acquired in hospital are an important cause of morbidity and mortality in very preterm infants. Several small trials have suggested that supplementing the enteral diet of very preterm infants with lactoferrin, an antimicrobial protein processed from cow's milk, prevents infections and associated complications. The aim of this large randomised controlled trial was to collect data to enhance the validity and applicability of the evidence from previous trials to inform practice. Methods In this randomised placebo-controlled trial, we recruited very preterm infants born before 32 weeks' gestation in 37 UK hospitals and younger than 72 h at randomisation. Exclusion criteria were presence of a severe congenital anomaly, anticipated enteral fasting for longer than 14 days, or no realistic prospect of survival. Eligible infants were randomly assigned (1:1) to receive either enteral bovine lactoferrin (150 mg/kg per day; maximum 300 mg/day; lactoferrin group) or sucrose (same dose; control group) once daily until 34 weeks' postmenstrual age. Web-based randomisation minimised for recruitment site, gestation (completed weeks), sex, and single versus multifetal pregnancy. Parents, caregivers, and outcome assessors were unaware of group assignment. The primary outcome was microbiologically confirmed or clinically suspected late-onset infection (occurring >72 h after birth), which was assessed in all participants for whom primary outcome data was available by calculating the relative risk ratio with 95% CI between the two groups. The trial is registered with the International Standard Randomised Controlled Trial Number 88261002. Findings We recruited 2203 participants between May 7, 2014, and Sept 28, 2017, of whom 1099 were assigned to the lactoferrin group and 1104 to the control group. Four infants had consent withdrawn or unconfirmed, leaving 1098 infants in the lactoferrin group and 1101 in the sucrose group. Primary outcome data for 2182 infants (1093 [99·5%] of 1098 in the lactoferrin group and 1089 [99·0] of 1101 in the control group) were available for inclusion in the modified intention-to-treat analyses. 316 (29%) of 1093 infants in the intervention group acquired a late-onset infection versus 334 (31%) of 1089 in the control group. The risk ratio adjusted for minimisation factors was 0·95 (95% CI 0·86–1·04; p=0·233). During the trial there were 16 serious adverse events for infants in the lactoferrin group and 10 for infants in the control group. Two events in the lactoferrin group (one case of blood in stool and one death after intestinal perforation) were assessed as being possibly related to the trial intervention. Interpretation Enteral supplementation with bovine lactoferrin does not reduce the risk of late-onset infection in very preterm infants. These data do not support its routine use to prevent late-onset infection and associated morbidity or mortality in very preterm infants. Funding UK National Institute for Health Research Health Technology Assessment programme (10/57/49)

Enteral lactoferrin supplementation for very preterm infants: a randomised placebo-controlled trial

Background Infections acquired in hospital are an important cause of morbidity and mortality in very preterm infants. Several small trials have suggested that supplementing the enteral diet of very preterm infants with lactoferrin, an antimicrobial protein processed from cow's milk, prevents infections and associated complications. The aim of this large randomised controlled trial was to collect data to enhance the validity and applicability of the evidence from previous trials to inform practice. Methods In this randomised placebo-controlled trial, we recruited very preterm infants born before 32 weeks' gestation in 37 UK hospitals and younger than 72 h at randomisation. Exclusion criteria were presence of a severe congenital anomaly, anticipated enteral fasting for longer than 14 days, or no realistic prospect of survival. Eligible infants were randomly assigned (1:1) to receive either enteral bovine lactoferrin (150 mg/kg per day; maximum 300 mg/day; lactoferrin group) or sucrose (same dose; control group) once daily until 34 weeks' postmenstrual age. Web-based randomisation minimised for recruitment site, gestation (completed weeks), sex, and single versus multifetal pregnancy. Parents, caregivers, and outcome assessors were unaware of group assignment. The primary outcome was microbiologically confirmed or clinically suspected late-onset infection (occurring >72 h after birth), which was assessed in all participants for whom primary outcome data was available by calculating the relative risk ratio with 95% CI between the two groups. The trial is registered with the International Standard Randomised Controlled Trial Number 88261002. Findings We recruited 2203 participants between May 7, 2014, and Sept 28, 2017, of whom 1099 were assigned to the lactoferrin group and 1104 to the control group. Four infants had consent withdrawn or unconfirmed, leaving 1098 infants in the lactoferrin group and 1101 in the sucrose group. Primary outcome data for 2182 infants (1093 [99·5%] of 1098 in the lactoferrin group and 1089 [99·0] of 1101 in the control group) were available for inclusion in the modified intention-to-treat analyses. 316 (29%) of 1093 infants in the intervention group acquired a late-onset infection versus 334 (31%) of 1089 in the control group. The risk ratio adjusted for minimisation factors was 0·95 (95% CI 0·86–1·04; p=0·233). During the trial there were 16 serious adverse events for infants in the lactoferrin group and 10 for infants in the control group. Two events in the lactoferrin group (one case of blood in stool and one death after intestinal perforation) were assessed as being possibly related to the trial intervention. Interpretation Enteral supplementation with bovine lactoferrin does not reduce the risk of late-onset infection in very preterm infants. These data do not support its routine use to prevent late-onset infection and associated morbidity or mortality in very preterm infants. Funding UK National Institute for Health Research Health Technology Assessment programme (10/57/49)