26 research outputs found
Family structure, parent-child conversation time and substance use among Chinese adolescents
<p>Abstract</p> <p>Background</p> <p>The family plays a vital role in shaping adolescent behaviours. The present study investigated the associations between family structure and substance use among Hong Kong Chinese adolescents.</p> <p>Methods</p> <p>A total of 32,961 Form 1 to 5 (grade 7-12 in the US) Hong Kong students participated in the Youth Smoking Survey in 2003-4. An anonymous questionnaire was used to obtain information about family structure, daily duration of parent-child conversation, smoking, alcohol drinking and drug use. Logistic regression was used to calculate the adjusted odds ratios (OR) for each substance use by family structure.</p> <p>Results</p> <p>Adjusting for sex, age, type of housing, parental smoking and school, adolescents from non-intact families were significantly more likely to be current smokers (OR = 1.62), weekly drinkers (OR = 1.72) and ever drug users (OR = 1.72), with significant linear increases in ORs from maternal, paternal to no-parent families compared with intact families. Furthermore, current smoking (OR = 1.41) and weekly drinking (OR = 1.46) were significantly more common among adolescents from paternal than maternal families. After adjusting for parent-child conversation time, the ORs for non-intact families remained significant compared with intact families, but the paternal-maternal differences were no longer significant.</p> <p>Conclusions</p> <p>Non-intact families were associated with substance use among Hong Kong Chinese adolescents. The apparently stronger associations with substance use in paternal than maternal families were probably mediated by the poorer communication with the father.</p
Prevalencia del VIH en niños, niñas y adolescentes en situación de calle y explotación sexual comercial: una revisión sistemática
Proteome-wide Lysine Glutarylation Profiling of the <i>Mycobacterium tuberculosis</i> H37Rv
Lysine
glutarylation, a new protein posttranslational modification
(PTM), was recently identified and characterized in both prokaryotic
and eukaryotic cells. To explore the distribution of lysine glutarylation
in <i>Mycobacterium tuberculsosis</i>, by using a comprehensive
method combining the immune affinity peptide enrichment by the glutaryl-lysine
antibody with LC–MS, we finally identified 41 glutarylation
sites in 24 glutarylated proteins from <i>M. tuberculosis</i>. These glutarylated proteins are involved in various cellular functions
such as translation and metabolism and exhibit diverse subcellular
localizations. Three common glutarylated proteins including 50S ribosomal
protein L7/L12, elongation factor Tu, and dihydrolipoamide succinyltransferase
are shared between <i>Escherichia coli</i> and <i>M. tuberculosis</i>. Moreover, comparison with other PTMs characterized in <i>M. tuberculosis</i>, 15 glutarylated proteins, are found to be both acetylated and succinylated.
Notably, several stress-response-associated proteins including HspX
are glutarylated. Our data provide the first analysis of <i>M. tuberculosis</i> lysine glutarylated proteins. Further studies on the role of the
glutarylated proteins will unveil the molecular mechanisms of glutarylation
underlying <i>M. tuberculosis</i> physiology and pathogenesis