A randomised controlled trial of supplemental oxygen versus medical air during exercise training in people with chronic obstructive pulmonary disease: Supplemental oxygen in pulmonary rehabilitation trial (SuppORT) (Protocol)

© 2016 Alison et al. Background: Oxygen desaturation during exercise is common in people with chronic obstructive pulmonary disease (COPD). The aim of the study is to determine, in people with COPD who desaturate during exercise, whether supplemental oxygen during an eight-week exercise training program is more effective than medical air (sham intervention) in improving exercise capacity and health-related quality of life both at the completion of training and at six-month follow up. Methods/Design: This is a multi-centre randomised controlled trial with concealed allocation, blinding of participants, exercise trainers and assessors, and intention-to-treat analysis. 110 people with chronic obstructive pulmonary disease who demonstrate oxygen desaturation lower than 90 % during the six-minute walk test will be recruited from pulmonary rehabilitation programs in seven teaching hospitals in Australia. People with chronic obstructive pulmonary disease on long term oxygen therapy will be excluded. After confirmation of eligibility and baseline assessment, participants will be randomised to receive either supplemental oxygen or medical air during an eight-week supervised treadmill and cycle exercise training program, three times per week for eight weeks, in hospital outpatient settings. Primary outcome measures will be endurance walking capacity assessed by the endurance shuttle walk test and health-related quality of life assessed by the Chronic Respiratory Disease Questionnaire. Secondary outcomes will include peak walking capacity measured by the incremental shuttle walk test, dyspnoea via the Dyspnoea-12 questionnaire and physical activity levels measured over seven days using an activity monitor. All outcomes will be measured at baseline, completion of training and at six-month follow up. Discussion: Exercise training is an essential component of pulmonary rehabilitation for people with COPD. This study will determine whether supplemental oxygen during exercise training is more effective than medical air in improving exercise capacity and health-related quality of life in people with COPD who desaturate during exercise. Trial registration: Australian New Zealand Clinical Trials Registry ACTRN12612000395831 , 5th Jan,201

Using machine learning to identify important predictors of COVID-19 infection prevention behaviors during the early phase of the pandemic

Before vaccines for coronavirus disease 2019 (COVID-19) became available, a set of infection-prevention behaviors constituted the primary means to mitigate the virus spread. Our study aimed to identify important predictors of this set of behaviors. Whereas social and health psychological theories suggest a limited set of predictors, machine-learning analyses can identify correlates from a larger pool of candidate predictors. We used random forests to rank 115 candidate correlates of infection-prevention behavior in 56,072 participants across 28 countries, administered in March to May 2020. The machine-learning model predicted 52% of the variance in infection-prevention behavior in a separate test sample—exceeding the performance of psychological models of health behavior. Results indicated the two most important predictors related to individual-level injunctive norms. Illustrating how data-driven methods can complement theory, some of the most important predictors were not derived from theories of health behavior—and some theoretically derived predictors were relatively unimportant

A many-analysts approach to the relation between religiosity and well-being

The relation between religiosity and well-being is one of the most researched topics in the psychology of religion, yet the directionality and robustness of the effect remains debated. Here, we adopted a many-analysts approach to assess the robustness of this relation based on a new cross-cultural dataset (N=10,535 participants from 24 countries). We recruited 120 analysis teams to investigate (1) whether religious people self-report higher well-being, and (2) whether the relation between religiosity and self-reported well-being depends on perceived cultural norms of religion (i.e., whether it is considered normal and desirable to be religious in a given country). In a two-stage procedure, the teams first created an analysis plan and then executed their planned analysis on the data. For the first research question, all but 3 teams reported positive effect sizes with credible/confidence intervals excluding zero (median reported β=0.120). For the second research question, this was the case for 65% of the teams (median reported β=0.039). While most teams applied (multilevel) linear regression models, there was considerable variability in the choice of items used to construct the independent variables, the dependent variable, and the included covariates

Mapping morality with a compass: testing the theory of ‘morality as cooperation’ with a new questionnaire

Morality-as-Cooperation (MAC) is the theory that morality is a collection of biological and cultural solutions to the problems of cooperation recurrent in human social life. MAC uses game theory to identify distinct types of cooperation, and predicts that each will be considered morally relevant, and each will give rise to a distinct moral domain. Here we test MAC's predictions by developing a new self-report measure of morality, the Morality-as-Cooperation Questionnaire (MAC-Q), and comparing its psychometric properties to those of the Moral Foundations Questionnaire (MFQ). Over four studies, the results support MAC's seven-factor model of morality, but not the MFQ's five-factor model. Thus MAC emerges as the best available compass with which to explore the moral landscape

Parent–child personality similarity and differential autonomy support toward siblings

Since parental differential treatment is related to more adjustment difficulties over and above main effects of parental treatment, it is important to understand under what conditions differential parenting is likely to occur. Using a within-family design, this study focused on between-sibling differences in parent–child personality similarity as a potential predictor of differential autonomy support from fathers and mothers. Longitudinal data (6 annual waves) of 497 target adolescents (56.9% boys,Mage at T1 = 13.03), one of their siblings (N = 416, Mage at T1 = 14.92), their fathers (N = 446, Mage at T1 = 46.74), and their mothers (N = 495,Mage at T1 = 44.41) were used. Parent–child personality similarity was determined based on distinctive profile correlations using the Big Five personality inventory. Structural Equation Modeling showed that the association between sibling differences in mother–child similarity and maternal autonomy support was positive and significant at the between-family level, and not at the within-family level. This means that, in families where one sibling was relatively more similar to the mother, the sibling with closer resemblance to the mother received relatively more autonomy support. No significant effects were found for fathers’ differential autonomy support. The present study highlights the importance of considering parent–child similarity in personality for understanding differences between siblings in maternal autonomy support

The developmental order of emotional and cognitive empathy in adolescents, and the role of mothers

This four-year study with annual measurements investigated the longitudinal interplay between affective and cognitive empathy in adolescents and their mothers. We studied 1) whether the developmental order of empathy in adolescence progresses from affective to cognitive empathy, or vice versa; 2) whether mothers’ empathy predicts their children’s empathy development; 3) whether adolescent gender moderates such intergenerational transmission from mothers to adolescents; and 4) whether inter-respondent differences in empathy were more stable for affective or cognitive empathy, and for adolescents or for mothers. Results indicated that affective empathy positively predicted the development of cognitive empathy one year later, but not vice versa. Mothers’ greater cognitive empathy predicted increasing cognitive empathy over time in daughters, but not in sons. Inter-respondent differences were more stable for affective empathy than for cognitive empathy in adolescents. In mothers, both empathy dimensions were equally stable, and more stable than in adolescents. This study thereby suggests that the developmental order of empathy in adolescence progresses from affective to cognitive empathy, in contrast to prior experimental and theoretical work which has emphasized the reverse direction of effects. It further offers support for the intergenerational transmission of cognitive empathy over time. Together with the lower stability of cognitive empathy, these findings suggest that adolescence is a developmentally sensitive period for cognitive empathy