British HIV Association guidelines for the management of tuberculosis in adults living with HIV 2019

The overall purpose of these guidelines is to help physicians manage adults with tuberculosis (TB)/human immunodeficiency virus (HIV) co‐infection. Recommendations for the treatment of TB in HIV‐positive adults are similar to those in HIV‐negative adults. Of note, the term “HIV” refers to HIV‐1 throughout these guidelines

Comparative Studies on the Bone‐marrow, Blood and Gastric Juice Culture of Tubercle Bacilli in Children

Bone‐marrow (bm), blood (b) and gastric juice (gj) cultures have been taken from 51 cases of primary complex (bm. 11, b. 3, gj. 5 pos.), 9 cases of t.b. of serous membranes (bm. 3, b. 0, gj. 0 pos.), 9 cases of miliary tuberculosis (bm. 4, b. 0, gj. 2 pos.) and 16 cases of t.b. meningitis (bm. 8, b. 2, gj. 2 pos.). The practical and theoretical importance of these findings is discussed. Copyright © 1953, Wiley Blackwell. All rights reserve

Does Prophylactic Vaccination Favour the Development of Poliomyelitis?

Seventy six cases of poliomyelitis have been admitted in St. Sophie Children's Hospital during the autumn of 1950. In seventeen of them there was a history of previous vaccination with mixed vaccine (pertussis‐tetanus‐diphtheria). The interval between vaccination and the appearance of paralysis was 2–14 days. In 75 % of the cases the paralysis occurred in the vaccinated limb. Copyright © 1953, Wiley Blackwell. All rights reserve

Serum and urine amino acids in infantile toxicosis

The serum and urine amino acids of 45 infants and babies suffering from toxicosis were studied by paper chromatography. In the serum there was no deviation from the normal. In the urine there were observed 14 to 18 amino acids estimated as an increased amount for each one. Eight days after admission there was still an augmented excretion of amino acids (12 to 14) in the urine. It is believed that the renal damages in toxicosis must be incriminated for the aminoaciduria observed. © 1958 The C. V. Mosby Company

Blood plasma levels and urinary excretion of ascorbic acid before and after a test dose in children with severe thalassemia

Summary1.The plasma ascorbic acid levels were determined in 22 children with severe thalassemia and in 12 normal children before and after an intramuscular injection of 50 mg. per kilogram of ascorbic acid. In 5 of the normal and 5 of the anemic children the urinary excretion of ascorbic acid before and after the test dose was also investigated.2.Before the injection of the test dose, the plasma ascorbic acid levels were invariably lower in the children with thalassemia than in the normal ones, and especially so in those with considerable splenomegaly. The test dose produced a greater initial rise, followed by a more rapid fall in the plasma levels of the anemic subjects.3.The urinary excretion of ascorbic acid before the test dose was considerably lower than normal in the children with thalassemia. The test dose produced a very similar initial rise in the renal elimination of the vitamin in both the normal and the anemic children, but this was followed by a decline in the rate of excretion which was more rapid in the anemic children. The over-all retention of injected ascorbic acid was considerably greater in the children with thalassemia.4.These observations suggest a mild ascorbic acid deficiency in children with severe thalassemia. The significance of this deficiency is discussed. © 1961 The C. V. Mosby Company