Citizenship and the accommodation of cultural minorities

The concept of citizenship can be said to be historically linked to rights associated with membership in a political community. These include civil, political and social rights. However, in the context of cultural diversity, these rights are arguably insufficient for cultural minorities, who by virtue of their membership in a minority group are disadvantaged. Therefore, the challenge is how to remedy this disadvantage and secure equal citizenship for cultural minorities. This thesis considers the work of three contemporary theorists who have provided innovative responses to this challenge: Will Kymlicka, Bhikhu Parekh and Brian Barry. Kymlicka and Parekh are both multicultural theorists whose general aim is to protect the integrity of minority groups via the notion of group-differentiated rights. However, Kymlicka’s framework focuses on the promotion of individual autonomy, which is problematic in lieu of the fact that culturally diverse societies will contain groups that do not attach primacy to liberal principles. Parekh’s framework fares better because it focuses on the value of cultural diversity and recognises that in the context of genuine diversity, establishing fair terms of justice for different communities involves intercultural dialogue. However, Parekh’s framework is let down by an implicit association with liberal values and a vague conception of how intercultural dialogue should proceed during hard cases of disagreement. An alternative to the multiculturalist approach is the work of Brian Barry who dismisses the notion of group-differentiated rights altogether as he believes the universal conception of citizenship will suffice in accommodating minority groups. However, Barry’s framework misses the mark because he fails to understand the significance of culture to its adherents and moreover, his position is arguably closer to the multiculturalist position than he concedes. To secure equal citizenship for disadvantaged cultural minorities, this thesis argues that a contextual approach to intercultural dialogue constitutes the most plausible response to hard cases of disagreements between majority and minority communities, and, furthermore, it argues that a contextual approach to intercultural dialogue can give rise to a common set of values and commitments that can underline an overarching British identity

Multi-satellite altimetry and GOCE geoid based surface and subsurface currents in the Mediterranean Sea

Peer ReviewedPostprint (published version

Synthesis of Cobalt Nanowires on Porous Anodic Alumina Template Using Electrochemical Deposition

Electrochemical deposition has been widely used for synthesis of metal nanowires (NWs) on the porous template. In this paper, the effect of potential and electrolyte concentration on cobalt (Co) NWs formation through porous anodic alumina template has been investigated using direct-current electrodepostion at 0.75~2 V together with the high 0.5 M and low 0.1 M cobalt sulfurate based electrolyte. Scanning electron microscopy and grazing incidence X-ray diffraction were used to examine the nanostructure, morphology and phase of Co NWs. The current vs time curve was recorded for understanding the growth behavior. Too low potential of 0.75 V is not favored for Co NWs formation due to insufficient driving force while too high potential of 2 V ruins the NWs growth owing to hydrogen generation in reduction reaction. The uniform crystalline Co NWs can be obtained by the proper potential of 1V and concentration of 0.5 M at an average growth rate of 964 nm/min

Disruption of Smad4 impairs TGF-β/Smad3 and Smad7 transcriptional regulation during renal inflammation and fibrosis in vivo and in vitro

The mechanism by which TGF-β regulates renal inflammation and fibrosis is largely unclear; however, it is well accepted that its biological effects are mediated through Smad2 and Smad3 phosphorylation. Following activation, these Smads form heteromeric complex with Smad4 and translocate into the nucleus to bind and regulate the expression of target genes. Here we studied the roles of Smad4 to regulate TGF-β signaling in a mouse model of unilateral ureteral obstruction using conditional Smad4 knockout mice and in isolated Smad4 mutant macrophages and fibroblasts. Disruption of Smad4 significantly enhanced renal inflammation as evidenced by a greater CD45+ leukocyte and F4/80+ macrophage infiltration and upregulation of IL-1β, TNF-α, MCP-1, and ICAM-1 in the obstructed kidney and in IL-1β-stimulated macrophages. In contrast, deletion of Smad4 inhibited renal fibrosis and TGF-β1-induced collagen I expression by fibroblasts. Further studies showed that the loss of Smad4 repressed Smad7 transcription, leading to a loss of functional protein. This, in turn, inhibited IκBα expression but enhanced NF-κB activation, thereby promoting renal inflammation. Interestingly, deletion of Smad4 influenced Smad3-mediated promoter activities and the binding of Smad3 to the COL1A2 promoter, but not Smad3 phosphorylation and nuclear translocation, thereby inhibiting the fibrotic response. Thus, Smad4 may be a key regulator for the diverse roles of TGF-β1 in inflammation and fibrogenesis by interacting with Smad7 and Smad3 to influence their transcriptional activities in renal inflammation and fibrosis

Integral effect non-loca test results for the integral type reactor SMART-P using the VISTA facility

Paper presented at the 5th International Conference on Heat Transfer, Fluid Mechanics and Thermodynamics, South Africa, 1-4 July, 2007.The SMART-P a pilot plant of the integral type reactor SMART(System Integrated Modular Advanced Reactor) which has new innovative design features aimed at achieving a highly enhanced safety and improved economics. A test facility (VISTA) has been constructed to simulate the SMART-P which is a full height and 1/96 volume scaled test facility with respect to the SMART-P. The VISTA facility has been used to understand the thermal-hydraulic behavior including several operational transients and design basis accidents and finally it will contribute to verifying the system design of the SMART-P. During the past five years, several integral effect tests have been carried out and reported, including performance tests, MCP(Main Coolant Pump) transients, power transients and heatup or cooldown procedures. In the present study, the VISTA facility was subjected to the major safety related non-LOCA transient conditions in a primary and secondary system, including a power increase due to a CEDM (Control Element Drive Mechanism) withdrawal, a feedwater decrease and a steam flow increase in order to verify the safety analysis code for the SMART-P.cs201

Cardiovascular outcomes associated with use of clarithromycin: population based study

Study question What is the association between clarithromycin use and cardiovascular outcomes? Methods In this population based study the authors compared cardiovascular outcomes in adults aged 18 or more receiving oral clarithromycin or amoxicillin during 2005-09 in Hong Kong. Based on age within five years, sex, and calendar year at use, each clarithromycin user was matched to one or two amoxicillin users. The cohort analysis included patients who received clarithromycin (n=108 988) or amoxicillin (n=217 793). The self controlled case series and case crossover analysis included those who received Helicobacter pylori eradication treatment containing clarithromycin. The primary outcome was myocardial infarction. Secondary outcomes were all cause, cardiac, or non-cardiac mortality, arrhythmia, and stroke. Study answer and limitations The propensity score adjusted rate ratio of myocardial infarction 14 days after the start of antibiotic treatment was 3.66 (95% confidence interval 2.82 to 4.76) comparing clarithromycin use (132 events, rate 44.4 per 1000 person years) with amoxicillin use (149 events, 19.2 per 1000 person years), but no long term increased risk was observed. Similarly, rate ratios of secondary outcomes increased significantly only with current use of clarithromycin versus amoxicillin, except for stroke. In the self controlled case analysis, there was an association between current use of H pylori eradication treatment containing clarithromycin and cardiovascular events. The risk returned to baseline after treatment had ended. The case crossover analysis also showed an increased risk of cardiovascular events during current use of H pylori eradication treatment containing clarithromycin. The adjusted absolute risk difference for current use of clarithromycin versus amoxicillin was 1.90 excess myocardial infarction events (95% confidence interval 1.30 to 2.68) per 1000 patients. What this study adds Current use of clarithromycin was associated with an increased risk of myocardial infarction, arrhythmia, and cardiac mortality short term but no association with long term cardiovascular risks among the Hong Kong population

Bacterial cellulose as drug delivery system for optimizing release of immune checkpoint blocking antibodies

Immune checkpoint blocking therapy is a promising cancer treatment modality, though it has limitations such as systemic toxicity, which can often be traced to uncontrolled antibody spread. Controlling antibody release with delivery systems is, therefore, an attractive approach to reduce systemic antibody spread and potentially mitigate the side effects of checkpoint immunotherapy. Here, bacterial cellulose (BC) was produced and investigated as a delivery system for optimizing checkpoint-blocking antibody delivery. BC was produced in 24-well plates, and afterward, the edges were removed to obtain square-shaped BC samples with a surface of similar to 49 mm(2). This customization was necessary to allow smooth in vivo implantation. Scanning electron microscopy revealed the dense cellulose network within BC. Human IgG antibody was included as the model antibody for loading and release studies. IgG antibody solution was injected into the center of BC samples. In vitro, all IgG was released within 24 to 48 h. Cell culture experiments demonstrated that BC neither exerted cytotoxic effects nor induced dendritic cell activation. Antibody binding assays demonstrated that BC does not hamper antibody function. Finally, antibody-loaded BC was implanted in mice, and serum measurements revealed that BC significantly reduced IgG and anti-CTLA-4 spread in mice. BC implantation did not induce side effects in mice. Altogether, BC is a promising and safe delivery system for optimizing the delivery and release of checkpoint-blocking antibodies.Radiolog