Androsterone glucuronide to dehydroepiandrosterone sulphate ratio is discriminatory for obese Caucasian women with polycystic ovary syndrome

BACKGROUND: Androsterone glucuronide (ADTG) concentrations have been suggested as a marker of the effects of androgens at the target tissue level. As the mechanism for hyperandrogenemia in obese and nonobese polycystic ovary syndrome (PCOS) may differ, this study compared the different androgen parameters in non-obese compared to obese women with PCOS, and in normal subjects. METHODS: Eleven non-obese and 14 obese women with PCOS were recruited and compared to 11 control women without PCOS. Total testosterone, dehydroepiandrosterone sulphate (DHEAS), ADTG, and androstenedione were analysed using gold standard tandem mass spectrometry, and the free androgen index (FAI) was calculated. RESULTS: Total testosterone, ADTG and androstendione levels did not differ between non-obese (body mass index (BMI) ≤25 kg/m2) and obese PCOS (BMI >25 kg/m2) but all were significantly higher than for controls (p < 0.01). The ADTG to DHEAS ratio was significantly elevated 39 ± 6 (p < 0.01) in obese PCOS in comparison to non-obese PCOS and controls (28 ± 5 and 29 ± 4, respectively). The free androgen index (FAI) and insulin resistance (HOMA-IR) were significantly higher in obese PCOS compared to non-obese PCOS and controls (p < 0.01). DHEAS was significantly higher in the non-obese versus obese PCOS (p < 0.01). All androgen parameters were significantly lower and sex hormone binding globulin (SHBG) significantly higher in normal subjects compared to those with obese and non-obese PCOS. CONCLUSIONS: The ADTG:DHEAS ratio was significantly elevated in obese PCOS compared to non-obese PCOS and controls suggesting that this may be a novel biomarker discriminatory for obese PCOS subjects, perhaps being driven by higher hepatic 5α reductase activity increasing ADTG formation in these women

Anyone Can Become a Troll: Causes of Trolling Behavior in Online Discussions

In online communities, antisocial behavior such as trolling disrupts constructive discussion. While prior work suggests that trolling behavior is confined to a vocal and antisocial minority, we demonstrate that ordinary people can engage in such behavior as well. We propose two primary trigger mechanisms: the individual's mood, and the surrounding context of a discussion (e.g., exposure to prior trolling behavior). Through an experiment simulating an online discussion, we find that both negative mood and seeing troll posts by others significantly increases the probability of a user trolling, and together double this probability. To support and extend these results, we study how these same mechanisms play out in the wild via a data-driven, longitudinal analysis of a large online news discussion community. This analysis reveals temporal mood effects, and explores long range patterns of repeated exposure to trolling. A predictive model of trolling behavior shows that mood and discussion context together can explain trolling behavior better than an individual's history of trolling. These results combine to suggest that ordinary people can, under the right circumstances, behave like trolls.Comment: Best Paper Award at CSCW 201

Planar microfluidics - liquid handling without walls

The miniaturization and integration of electronic circuitry has not only made the enormous increase in performance of semiconductor devices possible but also spawned a myriad of new products and applications ranging from a cellular phone to a personal computer. Similarly, the miniaturization and integration of chemical and biological processes will revolutionize life sciences. Drug design and diagnostics in the genomic era require reliable and cost effective high throughput technologies which can be integrated and allow for a massive parallelization. Microfluidics is the core technology to realize such miniaturized laboratories with feature sizes on a submillimeter scale. Here, we report on a novel microfluidic technology meeting the basic requirements for a microfluidic processor analogous to those of its electronic counterpart: Cost effective production, modular design, high speed, scalability and programmability

A Case of Refractory Hypoglycemia with DPP-IV Inhibitors in a Patient with CKD and Paraproteinemia

Society of Hospital Medicine: Indiana Chapte

Variability in Basal Melting Beneath Pine Island Ice Shelf on Weekly to Monthly Timescales

Ocean‐driven basal melting of Amundsen Sea ice shelves has triggered acceleration, thinning, and grounding line retreat on many West Antarctic outlet glaciers. Here we present the first year‐long (2014) record of basal melt rate at sub‐weekly resolution from a location on the outer Pine Island Ice Shelf. Adjustment of the upper thermocline to local wind forced variability in the vertical Ekman velocity is the dominant control on basal melting at weekly to monthly timescales. Atmosphere‐ice‐ocean surface heat fluxes or changes in advection of modified Circumpolar Deep Water play no discernible role at these timescales. We propose that during other years, a deepening of the thermocline in Pine Island Bay driven by longer timescale processes may have suppressed the impact of local wind forcing on high‐frequency upper thermocline height variability and basal melting. This highlights the complex interplay between the different processes and their timescales that set the basal melt rate beneath Pine Island Ice Shelf

Development and Investigation of Communication Issues on a CubeSat-onboard Amateur Radio Payload with APRS Digipeater and Store-and-Forward Capabilities

Automatic Packet Reporting System (APRS) is originally a terrestrial packet communication system widely utilized by amateur radio stations to exchange various information. To extend this capability over a geographically broad coverage, a few microsatellites previously carried an APRS digipeater payload for global amateur community use, and then there have been proposals to do this on smaller nanosatellite platforms, such as the CubeSat. Although CubeSat is an attractive platform for this application – due to its substantially simpler design, lower cost, and faster development time – it also presents several technical challenges such as tight space, power, and communication link budgets. In this paper, we discuss the design, development and testing of an amateur radio payload that operates in the 145.825 MHz amateur frequency, consists of mostly commercial-of-the-shelf components and supports both APRS digipeater and store-and-forward (S&F) communication for remote data collection. The payload was carried as a technology demonstration mission of a 1U CubeSat constellation developed at the Kyushu Institute of Technology under the BIRDS-2 Project. Several amateur operators confirmed reception of the payload’s beacon message but full two-way communication failed due to uplink communication problems. This paper also tackles the investigation on the causes of failure through ground-based communication tests, as well as the recommendations from the findings

A Mutant Ahr Allele Protects the Embryonic Kidney from Hydrocarbon-Induced Deficits in Fetal Programming

Background: The use of experimental model systems has expedited the elucidation of pathogenetic mechanisms of renal developmental disease in humans and the identification of genes that orchestrate developmental programming during nephrogenesis

Enabling NATO’s Collective Defense: Critical Infrastructure Security and Resiliency (NATO COE-DAT Handbook 1)

In 2014 NATO’s Center of Excellence-Defence Against Terrorism (COE-DAT) launched the inaugural course on “Critical Infrastructure Protection Against Terrorist Attacks.” As this course garnered increased attendance and interest, the core lecturer team felt the need to update the course in critical infrastructure (CI) taking into account the shift from an emphasis on “protection” of CI assets to “security and resiliency.” What was lacking in the fields of academe, emergency management, and the industry practitioner community was a handbook that leveraged the collective subject matter expertise of the core lecturer team, a handbook that could serve to educate government leaders, state and private-sector owners and operators of critical infrastructure, academicians, and policymakers in NATO and partner countries. Enabling NATO’s Collective Defense: Critical Infrastructure Security and Resiliency is the culmination of such an effort, the first major collaborative research project under a Memorandum of Understanding between the US Army War College Strategic Studies Institute (SSI), and NATO COE-DAT. The research project began in October 2020 with a series of four workshops hosted by SSI. The draft chapters for the book were completed in late January 2022. Little did the research team envision the Russian invasion of Ukraine in February this year. The Russian occupation of the Zaporizhzhya nuclear power plant, successive missile attacks against Ukraine’s electric generation and distribution facilities, rail transport, and cyberattacks against almost every sector of the country’s critical infrastructure have been on world display. Russian use of its gas supplies as a means of economic warfare against Europe—designed to undermine NATO unity and support for Ukraine—is another timely example of why adversaries, nation-states, and terrorists alike target critical infrastructure. Hence, the need for public-private sector partnerships to secure that infrastructure and build the resiliency to sustain it when attacked. Ukraine also highlights the need for NATO allies to understand where vulnerabilities exist in host nation infrastructure that will undermine collective defense and give more urgency to redressing and mitigating those fissures.https://press.armywarcollege.edu/monographs/1951/thumbnail.jp