114 research outputs found
Novel Compact Multiband MIMO Antenna for Mobile Terminal
A novel compact MIMO antenna for personal digital assistant (PDA) and pad computer is proposed. The proposed antenna is composed by two multipatch monopole antennas which are placed 90° apart for orthogonal radiation. To strengthen the isolation, a T-shaped ground branch with proper dimension is used to generate an additional coupling path to lower the mutual coupling (below −15 dB), especially at GSM850/900 band. The proposed MIMO antenna is fabricated and tested, both the simulated and the measured results are presented, and some parametric studies are also demonstrated. In addition, there are some advantages about the proposed antenna such as simple structure, easy fabrication, and low cost
Fault Detection in High Speed Helical Gears Considering Signal Processing Method in Real Simulation
Optimizing SVM’s parameters based on backtracking search optimization algorithm for gear fault diagnosis
The accuracy of a support vector machine (SVM) classifier is decided by the selection of optimal parameters for the SVM. The Backtracking Search Optimization Algorithm (BSA) is often applied to resolve the global optimization problem and adapted to optimize SVM parameters. In this research, a SVM parameter optimization method based on BSA (BSA-SVM) is proposed, and the BSA-SVM is applied to diagnose gear faults. Firstly, a gear vibration signal can be decomposed into several intrinsic scale components (ISCs) by means of the Local Characteristics-Scale Decomposition (LCD). Secondly, the MPE can extract the fault feature vectors from the first few ISCs. Thirdly, the fault feature vectors are taken as the input vectors of the BSA-SVM classifier. The analysis results of BSA-SVM classifier show that this method has higher accuracy than GA (Genetic Algorithm) or PSO (Particles Swarm Algorithm) algorithms combined with SVM. In short, the BSA-SVM based on the MPE-LCD is suitable to diagnose the state of health gear
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Comparative linkage analysis and visualization of high-density oligonucleotide SNP array data
Background: The identification of disease-associated genes using single nucleotide polymorphisms (SNPs) has been increasingly reported. In particular, the Affymetrix Mapping 10 K SNP microarray platform uses one PCR primer to amplify the DNA samples and determine the genotype of more than 10,000 SNPs in the human genome. This provides the opportunity for large scale, rapid and cost-effective genotyping assays for linkage analysis. However, the analysis of such datasets is nontrivial because of the large number of markers, and visualizing the linkage scores in the context of genome maps remains less automated using the current linkage analysis software packages. For example, the haplotyping results are commonly represented in the text format. Results: Here we report the development of a novel software tool called CompareLinkage for automated formatting of the Affymetrix Mapping 10 K genotype data into the "Linkage" format and the subsequent analysis with multi-point linkage software programs such as Merlin and Allegro. The new software has the ability to visualize the results for all these programs in dChip in the context of genome annotations and cytoband information. In addition we implemented a variant of the Lander-Green algorithm in the dChipLinkage module of dChip software (V1.3) to perform parametric linkage analysis and haplotyping of SNP array data. These functions are integrated with the existing modules of dChip to visualize SNP genotype data together with LOD score curves. We have analyzed three families with recessive and dominant diseases using the new software programs and the comparison results are presented and discussed. Conclusions: The CompareLinkage and dChipLinkage software packages are freely available. They provide the visualization tools for high-density oligonucleotide SNP array data, as well as the automated functions for formatting SNP array data for the linkage analysis programs Merlin and Allegro and calling these programs for linkage analysis. The results can be visualized in dChip in the context of genes and cytobands. In addition, a variant of the Lander-Green algorithm is provided that allows parametric linkage analysis and haplotyping
Direct three-dimensional imaging of polymer-water interfaces by nanoscale hard X-ray phase tomography
We report three-dimensional (3D) direct imaging of complex surface-liquid interfaces by hard X-ray phase contrast tomography as a non-destructive approach for the morphological characterization of surfaces at the micro- and nanoscale in contact with water. Specifically{,} we apply this method to study the solid-air-water interface in hydrophobic macroporous polymethacrylate surfaces{,} and the solid-oil-water interface in slippery liquid-infused porous surfaces (SLIPS). Varying the isotropic spatial resolution allows the 3D quantitative characterization of individual polymer globules{,} globular clusters (porosity) as well as the infused lubricant layer on SLIPS. Surface defects were resolved at the globular level. We show the first application of X-ray nanotomography to hydrated surface characterizations and we anticipate that X-ray nanoscale imaging will open new ways for various surface/interface studies
Geometric Filterless Photodetectors for Mid-infrared Spin Light
Free-space circularly polarized light (CPL) detection, requiring polarizers
and waveplates, has been well established, while such spatial degree of freedom
is unfortunately absent in integrated on-chip optoelectronics. So far, those
reported filterless CPL photodetectors suffer from the intrinsic small
discrimination ratio, vulnerability to the non-CPL field components, and low
responsivity. Here, we report a distinct paradigm of geometric photodetectors
in mid-infrared exhibiting colossal discrimination ratio, close-to-perfect
CPL-specific response, a zero-bias responsivity of 392 V/W at room temperature,
and a detectivity of ellipticity down to 0.03 Hz. Our approach
employs plasmonic nanostructures array with judiciously designed symmetry,
assisted by graphene ribbons to electrically read their near-field optical
information. This geometry-empowered recipe for infrared photodetectors
provides a robust, direct, strict, and high-quality solution to on-chip
filterless CPL detection and unlocks new opportunities for integrated
functional optoelectronic devices
Clustering-guided novel unsupervised domain adversarial network for partial transfer fault diagnosis of rotating machinery
Unsupervised partial transfer fault diagnosis studies of rotating machinery have practical significance, which still exists some challenges, for example, the learned domain-specific statistics and parameters usually influence the learning effect of target-domain features to some degree, and the relatively scattered target-domain features will lead to negative transfer. To overcome those limitations and further improve partial transfer fault diagnosis performance, a clustering-guided novel unsupervised domain adversarial network is proposed in this paper. Firstly, a novel unsupervised domain adversarial network is constructed using domain-specific batch normalization to remove domain-specific information to enhance alignment between source and target domains. Secondly, embedded clustering strategy is designed to learn tightly clustered target-domain features to suppress negative transfer in partial domain adaptation process. Finally, a joint optimization objective function is defined to balance different losses to improve the training and diagnosis performance. Two experimental cases of bevel gearbox and bearing are used to validate the effectiveness and superiority of the proposed method in solving unsupervised partial transfer fault diagnosis problems
Tirofiban for Stroke without Large or Medium-Sized Vessel Occlusion
The effects of the glycoprotein IIb/IIIa receptor inhibitor tirofiban in patients with acute ischemic stroke but who have no evidence of complete occlusion of large or medium-sized vessels have not been extensively studied. In a multicenter trial in China, we enrolled patients with ischemic stroke without occlusion of large or medium-sized vessels and with a National Institutes of Health Stroke Scale score of 5 or more and at least one moderately to severely weak limb. Eligible patients had any of four clinical presentations: ineligible for thrombolysis or thrombectomy and within 24 hours after the patient was last known to be well; progression of stroke symptoms 24 to 96 hours after onset; early neurologic deterioration after thrombolysis; or thrombolysis with no improvement at 4 to 24 hours. Patients were assigned to receive intravenous tirofiban (plus oral placebo) or oral aspirin (100 mg per day, plus intravenous placebo) for 2 days; all patients then received oral aspirin until day 90. The primary efficacy end point was an excellent outcome, defined as a score of 0 or 1 on the modified Rankin scale (range, 0 [no symptoms] to 6 [death]) at 90 days. Secondary end points included functional independence at 90 days and a quality-of-life score. The primary safety end points were death and symptomatic intracranial hemorrhage. A total of 606 patients were assigned to the tirofiban group and 571 to the aspirin group. Most patients had small infarctions that were presumed to be atherosclerotic. The percentage of patients with a score of 0 or 1 on the modified Rankin scale at 90 days was 29.1% with tirofiban and 22.2% with aspirin (adjusted risk ratio, 1.26; 95% confidence interval, 1.04 to 1.53, P = 0.02). Results for secondary end points were generally not consistent with the results of the primary analysis. Mortality was similar in the two groups. The incidence of symptomatic intracranial hemorrhage was 1.0% in the tirofiban group and 0% in the aspirin group. In this trial involving heterogeneous groups of patients with stroke of recent onset or progression of stroke symptoms and nonoccluded large and medium-sized cerebral vessels, intravenous tirofiban was associated with a greater likelihood of an excellent outcome than low-dose aspirin. Incidences of intracranial hemorrhages were low but slightly higher with tirofiban
Methylprednisolone as Adjunct to Endovascular Thrombectomy for Large-Vessel Occlusion Stroke
Importance
It is uncertain whether intravenous methylprednisolone improves outcomes for patients with acute ischemic stroke due to large-vessel occlusion (LVO) undergoing endovascular thrombectomy.
Objective
To assess the efficacy and adverse events of adjunctive intravenous low-dose methylprednisolone to endovascular thrombectomy for acute ischemic stroke secondary to LVO.
Design, Setting, and Participants
This investigator-initiated, randomized, double-blind, placebo-controlled trial was implemented at 82 hospitals in China, enrolling 1680 patients with stroke and proximal intracranial LVO presenting within 24 hours of time last known to be well. Recruitment took place between February 9, 2022, and June 30, 2023, with a final follow-up on September 30, 2023.InterventionsEligible patients were randomly assigned to intravenous methylprednisolone (n = 839) at 2 mg/kg/d or placebo (n = 841) for 3 days adjunctive to endovascular thrombectomy.
Main Outcomes and Measures
The primary efficacy outcome was disability level at 90 days as measured by the overall distribution of the modified Rankin Scale scores (range, 0 [no symptoms] to 6 [death]). The primary safety outcomes included mortality at 90 days and the incidence of symptomatic intracranial hemorrhage within 48 hours.
Results
Among 1680 patients randomized (median age, 69 years; 727 female [43.3%]), 1673 (99.6%) completed the trial. The median 90-day modified Rankin Scale score was 3 (IQR, 1-5) in the methylprednisolone group vs 3 (IQR, 1-6) in the placebo group (adjusted generalized odds ratio for a lower level of disability, 1.10 [95% CI, 0.96-1.25]; P = .17). In the methylprednisolone group, there was a lower mortality rate (23.2% vs 28.5%; adjusted risk ratio, 0.84 [95% CI, 0.71-0.98]; P = .03) and a lower rate of symptomatic intracranial hemorrhage (8.6% vs 11.7%; adjusted risk ratio, 0.74 [95% CI, 0.55-0.99]; P = .04) compared with placebo.
Conclusions and Relevance
Among patients with acute ischemic stroke due to LVO undergoing endovascular thrombectomy, adjunctive methylprednisolone added to endovascular thrombectomy did not significantly improve the degree of overall disability.Trial RegistrationChiCTR.org.cn Identifier: ChiCTR210005172
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