A REVIEW OF ANALYTICAL TECHNIQUES FOR DETERMINATION OF ANTI-HIV DRUGS

Pharmaceutical analysis plays a very prominent role in quality assurance as well as quality control of bulk drugs and pharmaceutical formulations. Rapid increase in pharmaceutical industries and production of drug in various parts of the world has brought a rise in demand for new analytical techniques in the pharmaceutical industries. As a consequence, analytical method development has become the basic activity of analysis. From the times of yore, people were trying to find safe and sound ways to treat viral infections. In the current scenario, due to the emerging of new viruses, the development of drugs for their treatment is also gaining equal importance. Before launching to the market, these drugs should undergo a validation process. High-performance liquid chromatography (HPLC) coupled with ultraviolet (UV), Photodiode array detectors (PDA), Mass spectrophotometer (MS) detectors etc. is one of the fastest, safe and precise technologies used for determination and separation of pharmaceutical drugs, impurities and biological samples. HPLC is versatile and it takes less time for quantification of drugs as compared to old liquid chromatography techniques. Tenofovir disoproxil fumarate (TDF), Emtricitabine (FTC) and Efavirenz (EFV) is antiretroviral medicine used treat AIDS as well as chronic Hepatitis-B. It is used alone or with other HIV medications to help control HIV infection. The present review article assesses the published analytical methods and a variety of approach for investigation of TDF, FTC and EFV in bulk drug as well as pharmaceutical formulations including combinations. The present studies revealed that HPLC technique along with the spectroscopic have been most widely explored for the analysis. The investigatory review may provide the comprehensive details to the researchers who are working in the area of analytical research of TDF, FTC and EFV

POOR SOLUBILITY OF DRUG AND ITS FORMULATION: A REVIEW

This present paper discusses about the poor solubility of drug as a major challenge for drug formulation companies and researchers. Further, its various aspects and researchers’ perspective and future work through the review’s studies of past and current

PREDICTORS OF DEPRESSION IN PATIENTS DIAGNOSED WITH MYOCARDIAL INFARCTION AFTER PERCUTANEOUS CORONARY INTERVENTION: A LITERATURE REVIEW

Objective: This study identified the factors associated with depression in patients diagnosed with myocardial infarction (MI) who underwent percutaneous coronary intervention (PCI). Methods: We searched the literature using PubMed and Google Scholar from their inception in 2010 to 2022. The search terms were “myocardial infarction,” “depression,” and “percutaneous coronary intervention.” Studies which investigated factors associated with depression in patients diagnosed with MI who underwent typical medical procedures were searched. Results: Various commonly discussed factors were identified as possible risk factors for depression in patients who were diagnosed with MI and underwent PCI: gender; negative illness beliefs; neuroticism; autonomy; baseline depression scores; previous diagnosis of depression, anxiety, or stress; smoking; marital status; Type D personality; procedure; length of hospital stay; fat intake; functional disability; time engaged in physical activity; social support; and a history of angina, MI, coronary artery bypass graft surgery, PCI, diabetes mellitus, and stroke. Keywords: Depression, Myocardial Infarction, Percutaneous Coronary Intervention. Cite this Article: Ali Akbar Kolambil and Dr. Neelesh Chaubey, Predictors of Depression in Patients Diagnosed with Myocardial Infarction After Percutaneous Coronary Intervention: A Literature Review, International Journal of Advanced Research in Engineering and Technology (IJARET), 14(5), 2023, pp. 37-43

A comprehensive investigation on development of lightweight aluminium miniature gears by thermoelectric erosion machining process

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A Comparative Study of Different Materials for Manufacturing of Miniature Spur Gears by Spark Erosion Wire Cutting Process

Selection of suitable materials plays a key role in machining to produce durable and good quality micro parts and components as well as improve the productivity of machining processes. This paper presents the performance evaluation of Spark Erosion Wire Cutting (SEWC) for the manufacturing of miniature gears from different materials, namely stainless steel SS 304, aluminum 7075, copper, and brass. The major objectives of this performance evaluation of SEWC are to determine the effect of gear materials on the quality of the gears, the economic aspects of miniature gears, and the productivity of SEWC for fabricating miniature spur gears. The optimal range of SEWC parameters from past research works was considered for conducting experiments for this study. Four miniature spur gears were fabricated from each gear material. It was concluded from this study that 1) the use of SS 304 as miniature spur gear material results in a better surface finish than aluminum, copper and brass; 2) use of aluminum as miniature gear material is more productive than SS 304, copper and brass; 3) aluminum is more economical and material-efficient than SS 304, copper and brass to fabricate miniature gears by SEWC; 4) material lost in copper is higher as compared to other selected materials; and 5) cost of SS 304 miniature gear is more as compared to other fabricated gears by SEWC