904 research outputs found
Approximate subgroups of residually nilpotent groups.
We show that a K-approximate subgroup A of a residually nilpotent group G is contained in boundedly many cosets of a finite-by-nilpotent subgroup, the nilpotent factor of which is of bounded step. Combined with an earlier result of the author, this implies that A is contained in boundedly many translates of a coset nilprogression of bounded rank and step. The bounds are effective and depend only on K; in particular, if G is nilpotent they do not depend on the step of G. As an application we show that there is some absolute constant c such that if G is a residually nilpotent group, and if there is an integer n > 1 such that the ball of radius n in some Cayley graph of G has cardinality bounded by n c log log n , then G is virtually ( log n ) -step nilpotent
Shining light on the storm: Using high-frequency optical water quality sensors to characterize and interpret storm nutrient and carbon dynamics among contrasting land uses
Elevated nutrient concentrations present significant challenges to surface water quality management globally, and dissolved organic matter mediates several key biogeochemical processes. Storm events often dominate riverine loads of nitrate, phosphorus, and dissolved organic matter, and are expected to increase in frequency and intensity in many regions due to climate change. The recent development of in situ optical sensors has revolutionized water quality monitoring and has highlighted the important role storms play in water quality. This dissertation focuses on improving the application of in situ optical water quality sensors and interpreting the high-frequency data they produce to better understand biogeochemical and watershed processes that are critical for resource management.
We deployed in situ sensors to monitor water quality in three watersheds with contrasting land use / land cover, including agricultural, urban, and forested landscapes. The sensors measured absorbance of ultraviolet-visible light through the water column at 2.5 nanometer wavelength increments at 15-minute intervals for three years. These deployments provided a testbed to evaluate the sensors and improve models to predict concentrations of nitrate, three phosphorus fractions, and dissolved organic carbon using absorbance spectra and laboratory analyses through multivariate statistical techniques. In addition, an improved hysteresis calculation method was used to determine short-timescale storm dynamics for several parameters during 220 storm events.
Goals of each dissertation chapter were to: (1) examine the influences of seasonality, storm size, and dominant land use / land cover on storm dissolved organic carbon and nitrate hysteresis and loads; (2) evaluate the utility of the sensors to determine total, dissolved, and soluble reactive phosphorus concentrations in streams draining different land use / land covers, and perform the first statistically robust validation technique applied to optical water quality sensor calibration models; and (3) analyze storm event dissolved organic matter quantity and character dynamics by calculating hysteresis indices for DOC concentration and spectral slope ratio, and develop a novel analytical framework that leverages these high frequency measurements to infer biogeochemical and watershed processes. Each chapter includes key lessons and future recommendations for using in situ optical sensors to monitor water quality
Observational Constraints on the Ages of Molecular Clouds and the Star-Formation Timescale: Ambipolar-Diffusion--Controlled or Turbulence-Induced Star Formation?
We revisit the problem of the star formation timescale and the ages of
molecular clouds. The apparent overabundance of star-forming molecular clouds
over clouds without active star formation has been thought to indicate that
molecular clouds are "short-lived" and that star formation is "rapid". We show
that this statistical argument lacks self-consistency and, even within the
rapid star-formation scenario, implies cloud lifetimes of approximately 10 Myr.
We discuss additional observational evidence from external galaxies that
indicate lifetimes of molecular clouds and a timescale of star formation of
approximately 10 Myr . These long cloud lifetimes in conjunction with the rapid
(approximately 1 Myr) decay of supersonic turbulence present severe
difficulties for the scenario of turbulence-controlled star formation. By
contrast, we show that all 31 existing observations of objects for which the
linewidth, the size, and the magnetic field strength have been reliably
measured are in excellent quantitative agreement with the predictions of the
ambipolar-diffusion theory. Within the ambipolar-diffusion-controlled star
formation theory the linewidths may be attributed to large-scale non-radial
cloud oscillations (essentially standing large-amplitude, long-wavelength
Alfven waves), and the predicted relation between the linewidth, the size, and
the magnetic field is a natural consequence of magnetic support of
self-gravitating clouds.Comment: 7 pages, 2 figures, uses emulateapj; accepted for publication in Ap
The Initial Core Mass Function due to Ambipolar Diffusion in Molecular Clouds
We show that the ambipolar-diffusion--initiated fragmentation of molecular
clouds leads simply and naturally to an initial core mass function (CMF) which
is very similar to the initial stellar mass function (IMF) and in excellent
agreement with existing observations. This agreement is robust provided that
the three (input) free parameters remain within their range of values suggested
by observations. Other, observationally testable, predictions are made.Comment: 5 pages, 4 figures, accepted by MNRAS-
Learning from humans: combining imitation and deep reinforcement learning to accomplish human-level performance on a virtual foraging task
We develop a method to learn bio-inspired foraging policies using human data.
We conduct an experiment where humans are virtually immersed in an open field
foraging environment and are trained to collect the highest amount of rewards.
A Markov Decision Process (MDP) framework is introduced to model the human
decision dynamics. Then, Imitation Learning (IL) based on maximum likelihood
estimation is used to train Neural Networks (NN) that map human decisions to
observed states. The results show that passive imitation substantially
underperforms humans. We further refine the human-inspired policies via
Reinforcement Learning (RL), using on-policy algorithms that are more suitable
to learn from pre-trained networks. We show that the combination of IL and RL
can match human results and that good performance strongly depends on an
egocentric representation of the environment. The developed methodology can be
used to efficiently learn policies for unmanned vehicles which have to solve
missions in an open field environment.Comment: 24 pages, 15 figure
Number of HIV-1 founder variants is determined by the recency of the source partner infection
During sexual transmission, the high genetic diversity of HIV-1 within an individual is frequently reduced to one founder variant that initiates infection. Understanding the drivers of this bottleneck is crucial to developing effective infection control strategies. Little is known about the importance of the source partner during this bottleneck. To test the hypothesis that the source partner affects the number of HIV founder variants, we developed a phylodynamic model calibrated using genetic and epidemiological data on all existing transmission pairs for whom the direction of transmission and the infection stage of the source partner are known. Our results suggest that acquiring infection from someone in the acute (early) stage of infection increases the risk of multiple-founder variant transmission compared with acquiring infection from someone in the chronic (later) stage of infection. This study provides the first direct test of source partner characteristics to explain the low frequency of multiple-founder strain infections
Effects of steady state free precession parameters on cardiac mass, function, and volumes
G0400444/Medical Research Council/United Kingdom
Wellcome Trust/United Kingdo
Costs and cost-effectiveness of delivering intermittent preventive treatment through schools in western Kenya
BACKGROUND: Awareness of the potential impact of malaria among school-age children has stimulated investigation into malaria interventions that can be delivered through schools. However, little evidence is available on the costs and cost-effectiveness of intervention options. This paper evaluates the costs and cost-effectiveness of intermittent preventive treatment (IPT) as delivered by teachers in schools in western Kenya. METHODS: Information on actual drug and non-drug associated costs were collected from expenditure and salary records, government budgets and interviews with key district and national officials. Effectiveness data were derived from a cluster-randomised-controlled trial of IPT where a single dose of sulphadoxine-pyrimethamine and three daily doses of amodiaquine were provided three times in year (once termly). Both financial and economic costs were estimated from a provider perspective, and effectiveness was estimated in terms of anaemia cases averted. A sensitivity analysis was conducted to assess the impact of key assumptions on estimated cost-effectiveness. RESULTS: The delivery of IPT by teachers was estimated to cost US 0.25 per child) whilst recurrent costs accounted for 86.8% (US 29.84 and the cost per case of Plasmodium falciparum parasitaemia averted was US 24.60 and 40.32 when the prices of antimalarial drugs and delivery costs were varied. Cost-effectiveness was most influenced by effectiveness of IPT and the background prevalence of anaemia. In settings where 30% and 50% of schoolchildren were anaemic, cost-effectiveness ratios were US$ 12.53 and 7.52, respectively. CONCLUSION: This study provides the first evidence that IPT administered by teachers is a cost-effective school-based malaria intervention and merits investigation in other settings
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Cathelicidin preserves intestinal barrier function in polymicrobial sepsis.
ObjectivesThe intestinal epithelium compartmentalizes the sterile bloodstream and the commensal bacteria in the gut. Accumulating evidence suggests that this barrier is impaired in sepsis, aggravating systemic inflammation. Previous studies reported that cathelicidin is differentially expressed in various tissues in sepsis. However, its role in sepsis-induced intestinal barrier dysfunction has not been investigated.DesignTo examine the role of cathelicidin in polymicrobial sepsis, cathelicidin wild-(Cnlp+/+) and knockout (Cnlp-/-) mice underwent cecal-ligation and puncture (CLP) followed by the assessment of septic mortality and morbidity as well as histological, biochemical, immunological, and transcriptomic analyses in the ileal tissues. We also evaluated the prophylactic and therapeutic efficacies of vitamin D3 (an inducer of endogenous cathelicidin) in the CLP-induced murine polymicrobial sepsis model.ResultsThe ileal expression of cathelicidin was increased by three-fold after CLP, peaking at 4 h. Knockout of Cnlp significantly increased 7-day mortality and was associated with a higher murine sepsis score. Alcian-blue staining revealed a reduced number of mucin-positive goblet cells, accompanied by reduced mucin expression. Increased number of apoptotic cells and cleavage of caspase-3 were observed. Cnlp deletion increased intestinal permeability to 4kD fluorescein-labeled dextran and reduced the expression of tight junction proteins claudin-1 and occludin. Notably, circulating bacterial DNA load increased more than two-fold. Transcriptome analysis revealed upregulation of cytokine/inflammatory pathway. Depletion of Cnlp induced more M1 macrophages and neutrophils compared with the wild-type mice after CLP. Mice pre-treated with cholecalciferol (an inactive form of vitamin D3) or treated with 1alpha, 25-dihydroxyvitamin D3 (an active form of VD3) had decreased 7-day mortality and significantly less severe symptoms. Intriguingly, the administration of cholecalciferol after CLP led to worsened 7-day mortality and the associated symptoms.ConclusionsEndogenous cathelicidin promotes intestinal barrier integrity accompanied by modulating the infiltration of neutrophils and macrophages in polymicrobial sepsis. Our data suggested that 1alpha, 25-dihydroxyvitamin D3 but not cholecalciferol is a potential therapeutic agent for treating sepsis
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