8 research outputs found
Arterial oxygen content is precisely maintained by graded erythrocytotic responses in settings of high/normal serum iron levels, and predicts exercise capacity: an observational study of hypoxaemic patients with pulmonary arteriovenous malformations.
- Author
- AD Kjeldsen
- AM Evans
- AN Friedman
- BE Phillips
- BM Silva
- BR O'Driscoll
- CG Mason
- CL Shovlin
- CL Shovlin
- CL Shovlin
- CL Shovlin
- CL Shovlin
- CL Shovlin
- Claire L. Shovlin
- CM Fletcher
- D Pennington
- DZ Levett
- E McLean
- ER Chilvers
- H Finnamore
- Hannah C. Tighe
- IS Anand
- JA Dutton
- JA Livesey
- James E. Jackson
- JE Van de Pette
- JJ Mager
- JL Hart
- L Boyer
- LC Ou
- Louisa C. Williams
- LS Valberg
- M Hu
- M Moussouttas
- ME Faughnan
- MF McMullin
- MK Whyte
- MK Whyte
- MP Grocott
- MW van Gent
- P Gupta
- P Shovlin CL Wilmshurst
- PB Terry
- PC HĂ©bert
- PM Sondel
- RC Hewes
- RD Thompson
- S Honda
- T Ueki
- Tracey Rouault
- V Cottin
- Vatshalan Santhirapala
- WB Porter
- WS Smellie
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 17/03/2014
- Field of study
Oxygen, haemoglobin and cardiac output are integrated components of oxygen transport: each gram of haemoglobin transports 1.34 mls of oxygen in the blood. Low arterial partial pressure of oxygen (PaO2), and haemoglobin saturation (SaO2), are the indices used in clinical assessments, and usually result from low inspired oxygen concentrations, or alveolar/airways disease. Our objective was to examine low blood oxygen/haemoglobin relationships in chronically compensated states without concurrent hypoxic pulmonary vasoreactivity.165 consecutive unselected patients with pulmonary arteriovenous malformations were studied, in 98 cases, pre/post embolisation treatment. 159 (96%) had hereditary haemorrhagic telangiectasia. Arterial oxygen content was calculated by SaO2 x haemoglobin x 1.34/100.There was wide variation in SaO2 on air (78.5-99, median 95)% but due to secondary erythrocytosis and resultant polycythaemia, SaO2 explained only 0.1% of the variance in arterial oxygen content per unit blood volume. Secondary erythrocytosis was achievable with low iron stores, but only if serum iron was high-normal: Low serum iron levels were associated with reduced haemoglobin per erythrocyte, and overall arterial oxygen content was lower in iron deficient patients (median 16.0 [IQR 14.9, 17.4]mls/dL compared to 18.8 [IQR 17.4, 20.1]mls/dL, p<0.0001). Exercise tolerance appeared unrelated to SaO2 but was significantly worse in patients with lower oxygen content (p<0.0001). A pre-defined athletic group had higher Hb:SaO2 and serum iron:ferritin ratios than non-athletes with normal exercise capacity. PAVM embolisation increased SaO2, but arterial oxygen content was precisely restored by a subsequent fall in haemoglobin: 86 (87.8%) patients reported no change in exercise tolerance at post-embolisation follow-up.Haemoglobin and oxygen measurements in isolation do not indicate the more physiologically relevant oxygen content per unit blood volume. This can be maintained for SaO2 ≥78.5%, and resets to the same arterial oxygen content after correction of hypoxaemia. Serum iron concentrations, not ferritin, seem to predict more successful polycythaemic responses
First-principles calculation of intrinsic defect chemistry and self-doping in PbTe
- Author
- A Alkauskas
- A Goyal
- A Svane
- A Zunger
- AD Becke
- BR Ortiz
- C Freysoldt
- C Freysoldt
- C Sgiarovello
- CG Walle Van de
- CG Walle Van de
- CG Walle Van de
- CG Walle Van de
- CR Hewes
- D West
- EA Albanesi
- G Kresse
- GJ Snyder
- H Peng
- H Zhu
- HJ Monkhorst
- I Opahle
- I Souza
- J Heyd
- J Heyd
- J Perdew
- JL Lyons
- JN Zemel
- JP Perdew
- K Biswas
- K Hoang
- K Hummer
- L Hedin
- M Fujimoto
- M Gajdoš
- M Lach-hab
- M Schenk
- MA Tumelero
- N Wang
- P Gorai
- P Gorai
- PE Blöchl
- R Chmielowski
- RF Brebrick
- RF Brebrick
- RN Tauber
- S Ahmad
- S Bajaj
- S Baroni
- S Curtarolo
- S Lany
- S Lany
- S Lany
- SH Wei
- V Stevanović
- V Stevanović
- W Chen
- W Chen
- W Tennant
- WE Spicer
- WF Li
- Y Pei
- Y Zhang
- YW Tsang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Exploring the Associations of Chronically Ill Patients’ Listening Styles and Medical Communication Competence in Patient–Doctor Interactions
- Author
- AS Nordness
- BG Ioan
- C Keinki
- CC Gearhart
- CG Thompson
- CJ McKinley
- DE Hewes
- DJ Cegala
- DJ Cegala
- DJ Cegala
- DL Rubin
- DL Worthington
- F Macagno
- GD Bodie
- GD Bodie
- GD Bodie
- HJ Carmack
- I Schrooten
- J Chapin
- J Davis
- J Davis
- J Hou
- J Keyton
- J Laugesen
- JB Weaver III
- JB Weaver III
- JD Johnson
- JL Chesebro
- K Watson
- KB Wright
- KB Zolnierek
- L Ramos Salazar
- Leslie Ramos Salazar
- LL Barker
- M Boyle
- M Johnson
- MB Wanzer
- MD Kirtley
- MK Shaw
- N Newhouse
- R Ahmed
- SL Sargent
- T Brown
- T Shepherd
- TA Avtgis
- TL Thompson
- WA Villaume
- X Huang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Incandescent Lamps
- Author
- AA Bright
- B Weber
- CG Suits
- CN Clark
- CW Pearson
- D Mann
- DH Fax
- E Fischer
- E Kauer
- EG Zubler
- EJ Covington
- EJ Covington
- EJ Covington
- Electric Lamp Association (ELA)
- EM Beesley
- FJ Harvey
- GR T’Jampens
- GW Stoer
- H Brons
- H Hörster
- H Schirmer
- HF Ivey
- I Langmuir
- I Langmuir
- IS Goldstein
- J Brett
- J Brett
- JA Moore
- JA Moore
- JF Waymouth
- JF Waymouth
- JH Dettingmeijer
- JR Coaton
- JR Law
- L Mandel
- LE Hoegler
- LJL Haenen
- M Cohue
- M Déribéré
- MF Gendre
- MR Vukcevich
- O Horacsek
- QK Shu
- R Clapp
- RA Hewes
- RS Bergman
- W Elenbaas
- W Elenbaas
- WE Thouret
- WJ Hoek van den
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
FMRFa receptor stimulated Ca2+ signals alter the activity of flight modulating central dopaminergic neurons in Drosophila melanogaster
- Author
- AN van den Pol
- B Brembs
- B Kiss
- BK Deb
- BR Malik
- C Timmerman
- C-T Shih
- CG Vecsey
- D Park
- D Sitaraman
- Deepti Trivedi
- DR Nässel
- F Friggi-Grelin
- F Port
- F Vonhoff
- FN Hamada
- G Cao
- G Venkiteswaran
- Gaiti Hasan
- Gregory S. Barsh
- I Mertens
- JM Gillespie
- JR Nambu
- JW Hell
- K Davie
- K Venkatesh
- K White
- KR Nesler
- L Cong
- LC Griffith
- LC Griffith
- LE Schneider
- M Balakireva
- MA Makos
- MJ Berridge
- MK Klose
- MN Nitabach
- N Yapici
- O Lenz
- P Mali
- Paul H. Taghert
- PDD Hsu
- PH Taghert
- Preethi Ravi
- Q Liu
- R Nichols
- R Nichols
- RS Hewes
- S Banerjee
- S Jayakumar
- S Kondo
- S Sadaf
- SE McGuire
- SH Sternberg
- SM Kim
- SP Bradley
- T Agrawal
- T Agrawal
- T Kitamoto
- T Pathak
- T-W Chen
- TW Dunn
- V Budnik
- V Croset
- WY Hwang
- X Chen
- X Chen
- X Jiang
- Y Kudo
- Y Zhou
- Z Wang
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
Chemotherapy-Associated Liver Injury: Impact on Surgical Management of Colorectal Cancer Liver Metastases
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- A Brouquet
- A Ferrero
- A Gramont de
- A Sahajpal
- AA Parikh
- AM Diehl
- AM D’Alessandro
- AM El-Badry
- B Nordlinger
- C Hubert
- C Huguet
- C Tournigand
- CG Moertel
- Charles A. Staley
- CK Sun
- CP Day
- CR Scoggins
- CS Cho
- D Azoulay
- D Gomez
- D Ribero
- D Zorzi
- DA Kooby
- DA Kooby
- DA Kooby
- David A. Kooby
- DC Madoff
- DE Kleiner
- EK Abdalla
- EK Abdalla
- FG Fernandez
- FG Fernandez
- FK Welsh
- H Nakano
- J Belghiti
- J Belghiti
- J Ward
- J Zeiss
- JC Hewes
- JN Vauthey
- JN Vauthey
- K Tanaka
- KE Behrns
- L McCormack
- L Rubbia-Brandt
- L Rubbia-Brandt
- LD DeLeve
- LS Szczepaniak
- M Hilden
- M Karoui
- M Klinger
- M Selzner
- M Shoup
- MA Adson
- MA Choti
- MM Aloysius
- MR Oliva
- MR Teli
- NF Schwenzer
- NN Mehta
- O Farges
- OJ Garden
- OM Jones
- P Hornboll
- P Sharma
- P Sorensen
- P Thirion
- PD Peppercorn
- Peter J. Kneuertz
- R Vetelainen
- S Kandutsch
- S Saadeh
- SC Lim
- SG Hubscher
- Shishir K. Maithel
- T Aloia
- TM Pawlik
- TR O’Rourke
- V Ratziu
- Y Fong
- Y Fong
- Z Li
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Literature
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Die Antibiotica
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- A rational approach to combined antibiotic therapy
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- Zusammenfassung
- Zusammenhang zwischen Dermatitis und Paraxininjektion
- Ăśber allergische Erscheinungen beim Gebrauch von Antibiotika
- Über die Anwendung der Antibiotika mit begrenztem Wirkungsbereich bei der örtlichen Behandlung von Hautkrankheiten. 1. Mitt. Die Lokalbehandlung mit Tyrothricin. Z. Haut- u. Geschl.-Kr. 20 14 (1956). 2. Mitt. Die Lokalbehandlung mit einer Kombination Tyrothricin und Xanthocillin. Z
- Ăśber die Wirksamkeit der Antibiotica Streptomycin und Tetracyclin bei der Behandlung der Acrodermatitis atrophicans Herxheimer
- Ăśber Penicillinase und ihre Inhibitoren
- Ăśber Penicillingewinnung und Penicillinwertbestimmung
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1961
- Field of study